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Immunologische Aspekte in der Reproduktionsmedizin

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Reproduktionsmedizin

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Zusammenfassung

Die embryonale Einnistung in das Endometrium zum Zeitpunkt des eng definierbaren mittlutealen Implantationsfensters stellt einen dynamischen Prozess dar, der einen adäquaten Reifungszustand der Gebärmutterschleimhaut bedingt. Etwaige Störungen der endometrialen Differenzierung werden dabei als Infertilitätsursache angesehen (Strowitzki et al. 2006).

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Literatur

  • Agrawal S, Pandey MK, Mandal S, Mishra L, Agarwal S (2002) Humoral immune response to an allogenic foetus in normal fertile women and recurrent aborters. BMC Pregnancy Childbirth 2: 6

    Article  PubMed  Google Scholar 

  • Bohlmann MK (2011) Effects and effectiveness of heparin in assisted reproduction. J Reprod Immunol 90: 82–90

    Article  PubMed  CAS  Google Scholar 

  • Bohlmann MK, Lüdders DW, Baumann K, Speer R, Marx TE, Diedrich K, Hornemann A (2008) Gestagenanwendung in der Schwangerschaft. Gynäkol Endokrinol 6: 171–176

    Article  CAS  Google Scholar 

  • Bohlmann MK, Luedders DW, Weichert J, Baumann K, Thill M, Diedrich K, Schleussner E, Hornemann A (2009) Thrombophile Gerinnungsstörungen als Risikofaktoren für habituelle Aborte. Gynäkologe 42: 17–24

    Article  CAS  Google Scholar 

  • Bohlmann MK, Toth B, Schleussner E (2010) Keine generelle Heparinisierung bei habituellen Aborten. Frauenarzt 51:1020–1021

    Google Scholar 

  • Carp HJ, Toder V, Mashiach S, Rabinovici J (1994) Effect of paternal leukocyte immunization on implantation after biochemical pregnancies and repeated failure of embryo transfer. Am J Reprod Immunol 31:112–115

    PubMed  CAS  Google Scholar 

  • Carrington B, Sacks G, Regan L (2005) Recurrent miscarriage: pathophysiology and outcome. Curr Opin Obstet Gynecol 17: 591–597

    Article  PubMed  Google Scholar 

  • Carter JD, Valeriano J, Vasey FB (2006) Tumor necrosis factor-alpha inhibition and VATER association: a causal relationship. J Rheumatol 33: 1014–1017

    PubMed  Google Scholar 

  • Clark DA (2010) Anti-TNF alpha therapy in immune-mediated subfertility: state of the art. J Reprod Immunol 85: 15–24

    Article  PubMed  CAS  Google Scholar 

  • Clark DA, Coulam CB, Stricker RB (2006) Is intravenous immunoglobulin (IVIG) efficacious in early pregnancy failure? A critical review and meta-analysis for patients who fail in vitro fertilization and embryo transfer (IVF). J Assist Reprod Genet 23:1–73

    Article  PubMed  Google Scholar 

  • Clowse ME (2010) The use of anti-TNFα medications for rheumatologic disease in pregnancy. Int J Womens Health 2: 199–209

    Article  PubMed  CAS  Google Scholar 

  • Daya S, Gunby J (2004) Luteal phase support in assisted reproduction cycles. Cochrane Database Syst Rev 3: CD004830

    Google Scholar 

  • Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG). Diagnostik und Therapie beim wiederholten Spontanabort. AWMFLeitlinien- Register Nr. 015/050 [http://www.dggg.de/fileadmin/public_docs/Leitlinien/2-2-2-wsa-2010.pdf]

  • Fahey JV, Schaefer TM, Channon JY, Wira CR (2005) Secretion of cytokines and chemokines by polarized human epithelial cells from the female reproductive tract. Hum Reprod 20: 1439–1446

    Article  PubMed  CAS  Google Scholar 

  • Gleicher N, Vidali A, Barad DH (2011) Successful treatment of unresponsive thin endometrium. Fertil Steril 95: 2123.e13–17

    Article  PubMed  Google Scholar 

  • Gutschalk CM, Herold-Mende CC, Fusenig NE, Mueller MM (2006) Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor promote malignant growth of cells from head and neck squamous cell carcinomas in vivo. Cancer Res 66: 8026–8036

    Article  PubMed  CAS  Google Scholar 

  • Haas DM, Ramsey PS (2008) Progestogen for preventing miscarriage. Cochrane Database Syst Rev 2: CD003511.

    Google Scholar 

  • Haider S, Knöfler M (2009) Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta 30: 111–123

    Article  PubMed  CAS  Google Scholar 

  • Hofer S, Heindl B, Meister FC, Maul H, Martin E, Sohn C, Weigand MA (2009) Blutungen während Schwangerschaft und Geburt. Gynäkologe 42: 55–69

    Article  Google Scholar 

  • Ito K, Tanaka T, Tsutsumi N, Obata F, Kashiwagi N (1999) Possible mechanisms of immunotherapy for maintaining pregnancy in recurrent spontaneous aborters: analysis of anti-idiotypic antibodies directed against autologous T-cell receptors. Hum Reprod 14: 650–655

    Article  PubMed  CAS  Google Scholar 

  • Kallen CB, Arici A (2003) Immune testing in fertility practice: truth or deception? Curr Opin Obstet Gynecol 18: 440–445

    Google Scholar 

  • Kämmerer U, von Wolff M, Markert UR (2004) Immunology of human endometrium. Immunobiology 209: 569–574

    Article  PubMed  Google Scholar 

  • Kleinstein J (2009) Aktive und passive Immunisierung. Gyn Endokrinol 7: 87–92

    Article  CAS  Google Scholar 

  • Kling C, Steinmann J, Westphal E, Magez J, Kabelitz D (2006) Adverse effects of intradermal allogeneic lymphocyte immunotherapy: acute reactions and role of autoimmunity. Hum Reprod 21: 429–435

    Article  PubMed  CAS  Google Scholar 

  • Kling C, Schmutzler A, Wilke G, Hedderich J, Kabelitz D (2008) Two-year outcome after recurrent implantation failure: prognostic factors and additional interventions. Arch Gynecol Obstet 278: 135–142

    Article  PubMed  Google Scholar 

  • Lédée N, Petitbarat M, Rahmati M, Dubanchet S, Chaouat G, Sandra O, Perrier-d’Hauterive S, Munaut C, Foidart JM (2011) New pre-conception immune biomarkers for clinical practice: interleukin- 18, interleukin- 15 and TWEAK on the endometrial side, G-CSF on the follicular side. J Reprod Immunol 88: 118–123

    Article  PubMed  Google Scholar 

  • Matsuyama T, Kobayashi Y, Honda I, Inoue M, Fujii A (1992) Analysis of HLA antigens and immunotherapy for infertile couples who failed to conceive after in vitro fertilization-embryo tubal replacement (IVF-ETR). Nihon Sanka Fujinka Gakkai Zasshi 44: 1241–1247

    PubMed  CAS  Google Scholar 

  • Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, De Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS ). J Thromb Haemost 4: 295–306

    Article  PubMed  CAS  Google Scholar 

  • Nelson SM, Greer IA (2008) The potential role of heparin in assisted conception. Hum Reprod Update 14: 623–645

    Article  PubMed  CAS  Google Scholar 

  • Oates-Whitehead RM, Haas DM, Carrier JA (2003) Progestogen for preventing miscarriage. Cochrane Database Syst Rev 4: CD003511

    Google Scholar 

  • Pandey MK, Rani R, Agrawal S (2005) An update in recurrent spontaneous abortion. Arch Gynecol Obstet 272: 95–108

    Article  PubMed  CAS  Google Scholar 

  • Parham P (2004) NK cells and trophoblasts: partners in pregnancy. J Exp Med 200: 951–955

    Article  PubMed  CAS  Google Scholar 

  • Piccinni MP, Giudizi MG, Biagiotti R, Beloni L, Giannarini L, Zampognaro S, Parrochi P, Manetti R, Annunziato F, Livi C, Romagnani S, Maggi E (1995) Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol 155: 128–133

    PubMed  CAS  Google Scholar 

  • Piccinni MP, Beloni L, Livi C, Maggi E, Scarselli G, Romagnani S (1998) Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nat Med 4: 1020–1024

    Article  PubMed  CAS  Google Scholar 

  • Practice Committee of the American Society for Reproductive Medicine (2008) Definitions of infertility and recurrent pregnancy loss. Fertil Steril 90: S60

    Google Scholar 

  • Quack KC, Vassiliadou N, Pudney J, Anderson DJ, Hill JA (2001) Leukocyte activation in the decidua of chromosomally normal and abnormal fetuses from women with recurrent abortion. Hum Reprod 16: 949–955

    Article  PubMed  CAS  Google Scholar 

  • Quenby S, Bates M, Doig T, Brewster J, Lewis-Jones DI, Johnson PM, Vince G (1999) Pre-implantation endometrial leukocytes in women with recurrent miscarriage. Hum Reprod 14: 2386–2391

    Article  PubMed  CAS  Google Scholar 

  • Rode L, Langhoff-Roos J, Andersson C, Dinesen J, Hammerum MS, Mohapeloa H, Tabor A (2009) Systematic review of progesterone for the prevention of preterm birth in singleton pregnancies. Acta Obstet Gynecol Scand 88: 1180–1189

    Article  PubMed  CAS  Google Scholar 

  • Rogenhofer N, Mittenzwei S, Thaler CJ, Diedrich K, Baumann K, Bohlmann MK (2011) Stellenwert der aktiven Immuntherapie bei Kinderwunschpatientinnen. Gyn Endokrinol 9: 215–218

    Article  CAS  Google Scholar 

  • Royal College of Obstetricians and Gynaecologist – RCOG. Guideline No. 17. The investigation and treatment of couples with recurrent miscariage. [http://www.rcog.org.uk/files/rcog-corp/GTG17recurrentmiscarriage.pdf]

  • Salmassi A, Schmutzler AG, Schaefer S, Koch K, Hedderich J, Jonat W, Mettler L (2005) Is granulocyte colony-stimulating factor level predictive for human IVF outcome? Hum Reprod 20: 2434–2440

    Article  PubMed  CAS  Google Scholar 

  • Scarpellini F, Sbracia M (2009) Use of granulocyte colony-stimulating factor for the treatment of unexplained recurrent miscarriage: a randomised controlled trial. Hum Reprod 24: 2703–2708

    Article  PubMed  CAS  Google Scholar 

  • Schindler AE (2005) Einsatz von Gestagenen in der Schwangerschaft – Therapeutische und präventive Anwendungsmöglichkeiten. Frauenarzt 46: 586–589

    Google Scholar 

  • Shakhar K, Rosenne E, Loewenthal R, Shakhar G, Carp H, Ben-Eliyahu S (2006) High NK cell activity in recurrent miscarriage: what are we really measuring? Hum Reprod 21: 2421–2425

    Article  PubMed  Google Scholar 

  • Strowitzki T, Germeyer A, Popovici R, von Wolff M (2006) The human endometrium as a fertility-determining factor. Hum Reprod Update 12: 617–630

    Article  PubMed  Google Scholar 

  • Tanaka T, Miyama M, Masuda M, Mizuno K, Sakamoto T, Umesaki N, Ogita S (2000) Production and physiological function of granulocyte colony-stimulating factor in non-pregnant human endometrial stromal cells. Gynecol Endocrinol 14: 399–404

    Article  PubMed  CAS  Google Scholar 

  • Winger EE, Reed JL, Ashoush S, Ahuja S, El-Toukhy T, Taranissi M (2009) Treatment with adalimumab (Humira) and intravenous immunoglobulin improves pregnancy rates in women undergoing IVF. Am J Reprod Immunol 61: 113–120

    Article  PubMed  CAS  Google Scholar 

  • Winger EE, Reed JL (2009) Treatment with tumor necrosis factor inhibitors and intravenous immunoglobulin improves live birth rates in women with recurrent spontaneous abortion. Am J Reprod Immunol 60: 8–16

    Article  Google Scholar 

  • Winger EE, Reed JL, Ashoush S, El-Toukhy T, Ahuja S, Taranissi M (2011a) Degree of TNF-α/IL-10 cytokine elevation correlates with IVF success rates in women undergoing treatment with Adalimumab (Humira) and IVIG. Am J Reprod Immunol 65: 610–618

    Article  CAS  Google Scholar 

  • Winger EE, Reed JL, Ashoush S, El-Toukhy T, Ahuja S, Taranissi M (2011b) Birth defect rates in women using adalimumab (Humira) and intravenous immunoglobulin to treat immunologic-based infertility in IVF. Am J Reprod Immunol 66: 237–241

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Schleswig-Holstein Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck

    Priv.- Doz. Dr. med. M.K. Bohlmann

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  1. Priv.- Doz. Dr. med. M.K. Bohlmann
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  1. Universitätsklinikum Schleswig-Holstein, Schleswig-Holstein, Campus Lübeck

    Klaus Diedrich  & Georg Griesinger  & 

  2. amedes, Zentrum für Endokrinologie, Kinderwunsch und Pränatale Medizin im Barkhof, Hamburg

    Michael Ludwig

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Bohlmann, M. (2013). Immunologische Aspekte in der Reproduktionsmedizin. In: Diedrich, K., Ludwig, M., Griesinger, G. (eds) Reproduktionsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30181-0_42

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  • DOI: https://doi.org/10.1007/978-3-642-30181-0_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-30180-3

  • Online ISBN: 978-3-642-30181-0

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