Zusammenfassung
Die Bewertung von Eizellen und Embryonen spielt in der Praxis eine wichtige Rolle im Hinblick auf die Abschätzung des Entwicklungspotenzials einer Zelle in vitro und in vivo. Der klinisch tätige Embryologe steht im Spannungsfeld zwischen den Wünschen seiner Patienten, der politischen Gesetzeslage seines Landes und seinen eigenen ethischen Prinzipien. Die Problematik der Mehrlingsschwangerschaft und deren Vermeidung durch z. B. den »single embryo transfer« sowie optimierte Implantations- und Schwangerschaftsraten sind Ausgangspunkt der Überlegungen einer Bewertung von Eizellen und Embryonen.
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Literatur
Alpha Scientists in Reproductive Medicine, ESHRE Special Interest Group Embryology (2011). Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Reprod Biomed Online 22: 632–646
Beyer DA, Griesinger G, Diedrich K, Schulze-Mosgau A (2011) Vitrifikation von Eizellen und Eizellen im Pronukleusstadium. Gynäkologe 44: 122–127
Borini A, Lagalla C, Cattoli M, Sereni E, Sciajno R, Flamigni C, Coticchio G (2005) Predictive factors for embryo implantation potential. Reprod Biomed Online 10: 653–668
Ciray HN, Karagenç L, Ulug U, Bener F, Bahceci M (2005) Use of both early cleavage and day 2 mononucleation to predict embryos with high implantation potential in intracytoplasmic sperm injection cycles. Fertil Steril 84: 1411–1416
Edirisinghe WR, Jemmott R, Smith C, Allan J (2005) Association of pronuclear Z score with rates of aneuploidy in in vitro-fertilised embryos. Reprod Fertil 17: 529–534
Familiari G, Relucenti M, Heyn R, Micara G, Correr S (2006) Three-dimensional structure of the zona pellucida at ovulation. Microsc Res Tech 69: 415–426
Gámiz P, Rubio C, de los Santos MJ, Mercader A, Simón C, Remohí J, Pellicer A (2003) The effect of pronuclear morphology on early development and chromosomal abnormalities in cleavage-stage embryos. Hum Reprod 18: 2413–2419
Gianaroli L, Magli MC, Ferraretti AP, Fortini D, Grieco N (2003) Pronuclear morphology and chromosomal abnormalities as scoring criteria for embryo selection. Fertil Steril 80: 341–349
Holte J, Berglund L, Milton K, Garello C, Genarelli G, Revelli A, Bergh T (2007) Construction of an evidence-based integrated morphology cleavage embryo score for implantation potential of embryos scored and transferred on day 2 after oocyte retrieval. Hum Reprod 22: 548–557
della Ragione T, Verheyen G, Papanikolaou EG, Van Landuyt L, Devroey P, Van Steirteghem A (2007) Developmental stage on day-5 and fragmentation rate on day-3 can influence the implantation potential of top-quality blastocysts in IVF cycles with single embryo transfer. Reprod Biol Endocrinol 26: 2
Kahraman S, Bahçe M, Samli H, Imirzalioğlu N, Yakisn K, Cengiz G, Dönmez E (2000) Healthy births and ongoing pregnancies obtained by preimplantation genetic diagnosis in patients with advanced maternal age and recurrent implantation failure. Hum Reprod 15: 2003–2007
Krüssel JS, Hirchenhain J, Bender HG (2004) Blastozystenkultur. Pro und Contra. Gynäkologe 7: 696–700
Lawler C, Baker HW, Edgar DH (2007) Relationships between timing of syngamy, female age and implantation potential in human in vitro- fertilised oocytes. Reprod Fertil 19: 482–487
Leese HJ, Sturmey RG, Baumann CG, McEvoy TG (2007) Embryo viability and metabolism: obeying the quiet rules. Hum Reprod 22: 3047–3050
Lundin K, Bergh C, Hardarson T (2001) Early embryo cleavage is a strong indicator of embryo quality in human IVF. Hum Reprod 16: 2652–2657
Montag M, Van Der Ven H (2001) Evaluation of pronuclear morphology as the only selection criterion for further embryo culture und transfer: results of a prospective multicentre study. Hum Reprod 16: 2384–2389
Nottola SA, Makabe S, Stallone T, Familiari G, Correr S, Macchiarelli G (2005) Surface morphology of the zona pellucida surrounding human blastocysts obtained after in vitro fertilization. Arch Histol Cytol 68: 133–141
Papanikolaou EG, Kolibianakis EM, Tournaye H, Venetis CA, Fatemi H, Tarlatzis B, Devroey P (2008) Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and meta-analysis. Hum Reprod 23: 91–99
Pedersen T (1998) Growth factors in the nucleus? J Cell Biol 143: 279–281
Pickering SJ, Taylor A, Johnson MH, Braude PR (1995) An analysis of multinucleated blastomere formation in human embryos. Hum Reprod 10: 1912–1922
Schwartz P, Hinney B, Nayudu PL, Michelmann HW (2003) Oocytesperm interaction in the course of IVF: a scanning electron microscopy analysis. Reprod Biomed Online 7: 205–210
Scott LA, Smith S (1998) The successful use of pronuclear embryo transfers the day following oocyte retrieval. Hum Reprod 13: 1003–1013
Scott L, Alvero R, Leondires M, Miller B (2000) The morphology of human pronuclear embryos is positively related to blastocyst development and implantation. Hum Reprod 15: 2394–2403
Scott L, Finn A, O‘Leary T, McLellan S, Hill J (2007) Morphologic parameters of early cleavage-stage embryos that correlate with fetal development and delivery: prospective and applied data for increased pregnancy rates. Hum Reprod 22: 230–240
Senn A, Urner F, Chanson A, Primi MP, Wirthner D, Germond M (2006) Morphological scoring of human pronuclear zygotes for prediction of pregnancy outcome. Hum Reprod 21: 234–239
Steer CV, Mills CL, Tan SL, Campbell S, Edwards RG (1992). The cumulative embryo score: a predictive embryo scoring technique to select the optimal number of embryos to transfer in an in-vitro fertilization and embryo transfer programme. Hum Reprod 7: 117–9
Tesarik J, Greco E (1999) The probability of abnormal preimplantation development can be predicted by a single static observation on pronuclear stage morphology. Hum Reprod 14: 1318–1323
Van Blerkom J, Davis P, Alexander S (2004) Occurrence of maternal and paternal spindles in unfertilized human oocytes: possible relationship to nucleation defects after silent fertilization. Reprod Biomed Online 8: 454–459
Zollner U, Zollner KP, Steck T, Dietl J (2003) Pronuclear scoring. Time for international standardization. J Reprod Med 48: 365–369
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Beyer, D., Diedrich, K. (2013). Bewertung von Eizellen und Embryonen. In: Diedrich, K., Ludwig, M., Griesinger, G. (eds) Reproduktionsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30181-0_19
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DOI: https://doi.org/10.1007/978-3-642-30181-0_19
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