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The Transcriptional Regulatory Network of Corynebacterium glutamicum

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Corynebacterium glutamicum

Part of the book series: Microbiology Monographs ((MICROMONO,volume 23))

Abstract

Over the past few years, the transcriptional regulation of gene expression was intensively studied in the Gram-positive model organism Corynebacterium glutamicum to shed light on its gene regulatory repertoire and the architecture of its transcriptional regulatory network. The combination of several computational methods revealed a set of at least 159 regulatory proteins, which form the minimal transcriptional regulatory repertoire of the type strain C. glutamicum ATCC 13032. Most of these regulatory proteins have a direct role as a DNA-binding transcription regulator or sigma factor, while others have less well-defined functions in transcriptional regulation. Considerable information on 88 transcription regulators has been accumulated and stored in the online reference database CoryneRegNet, leading to a data set of more than 1,000 interactions between regulatory proteins and their target genes. Based on this comprehensive collection of gene-regulatory data, we have achieved great improvements in understanding the regulatory and coregulatory interactions of the various transcription regulators, their connection by hierarchical cross-regulation, and the topology of the transcriptional regulatory network. The genome-wide reconstruction of the transcriptional regulatory network with the graph visualization feature of CoryneRegNet reveals a highly connected architecture that displays a modular and hierarchical structure without feedback regulation at the transcriptional level.

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Authors and Affiliations

  1. Institute for Genome Research and Systems Biology, Center for Biotechnology, Bielefeld University, Universitätsstraße 27, 33615, Bielefeld, Germany

    Jasmin Schröder

  2. Centrum für Biotechnologie, Universität Bielefeld, Universitätsstrasse 27, 33615, Bielefeld, Germany

    Andreas Tauch

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  1. Jasmin Schröder
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Correspondence to Andreas Tauch .

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Editors and Affiliations

  1. Technology for the Earth (RITE), Microbiology Research Group, Research Institute of Innovative, Kizu-cho 9-2, Soraku-gun, Kyoto, 619-0292, Japan

    Hideaki Yukawa

  2. Technology for the Earth (RITE), Research Institute of Innovative, Kizugawadai, Kizu-cho 9-2, Soraku-gun, Kyoto, 619-0292, Japan

    Masayuki Inui

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Schröder, J., Tauch, A. (2013). The Transcriptional Regulatory Network of Corynebacterium glutamicum . In: Yukawa, H., Inui, M. (eds) Corynebacterium glutamicum. Microbiology Monographs, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29857-8_8

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