Skip to main content
SpringerLink
Log in

Weichteiltumoren

  • Chapter
  • First Online:
Kinderchirurgie

  • 6336 Accesses

Zusammenfassung

Weichteiltumoren stellen eine komplexe Gruppe verschiedener Tumoren im Kindesalter mit mehr als 20 verschiedenen Entitäten dar. Prozentual machen sie ca. 5–8% aller kindlichen Tumoren aus. Sarkome sind maligne Tumoren, die von mesenchymalen Zellen ausgehen. Grundsätzlich kann man bei den Weichteilsarkomen zwischen den „RMS-artigen Weichteilsarkomen“ und den „nicht-RMS-artigen Weichteilsarkomen“ unterscheiden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Bisogno G, De RC, Gamboa Y, Sotti G, Ferrari A, Dallorso S, Donfrancesco A, Cecchetto G, Calderone M, Gandola L, Rosolen, A Carli M (2008) Improved survival for children with parameningeal rhabdomyosarcoma: results from the AIEOP soft tissue sarcoma committee. Pediatr Blood Cancer 50:1154–1158

    Article  PubMed  Google Scholar 

  • Bisogno G, Pastore G, Perilongo G, Sotti G, Cecchetto G, Dallorso S Carli M (2012) Long-term results in childhood rhabdomyosarcoma: a report from the Italian Cooperative Study RMS 79. Pediatr Blood Cancer 58:872–876

    Article  PubMed  Google Scholar 

  • Breneman J, Meza J, Donaldson SS, Raney RB, Wolden S, Michalski J, Laurie F, Rodeberg DA, Meyer W, Walterhouse D, Hawkins DS (2012) Local control with reduced-dose radiotherapy for low-risk rhabdomyosarcoma: a report from the Children’s Oncology Group D9602 study. Int J Radiat Oncol Biol Phys 83:720–726

    PubMed  Google Scholar 

  • Carli M, Ferrari A, Mattke A, Zanetti I, Casanova M, Bisogno G, Cecchetto G, Alaggio R, De SL, Koscielniak E, Sotti G, Treuner J (2005) Pediatric malignant peripheral nerve sheath tumor: the Italian and German soft tissue sarcoma cooperative group. J Clin Oncol 23:8422–8430

    Article  PubMed  Google Scholar 

  • Chisholm JC, Marandet J, Rey A, Scopinaro M, de Toledo JS, Merks JH, O’Meara A, Stevens M, COberlin O (2011) Prognostic factors after relapse in nonmetastatic rhabdomyosarcoma: a nomogram to better define patients who can be salvaged with further therapy. J Clin Oncol 29:1319–1325

    Article  PubMed  Google Scholar 

  • Combs SE, Behnisch W, Kulozik AE, Huber PE, Debus JSchulz-Ertner D (2007) Intensity Modulated Radiotherapy (IMRT) and Fractionated Stereotactic Radiotherapy (FSRT) for children with head-and-neck-rhabdomyosarcoma. BMC Cancer 7:177

    Article  PubMed  Google Scholar 

  • Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, Breneman J, Qualman SJ, Wiener E, Wharam M, Lobe T, Webber B, Maurer H, MDonaldson SS (2001) Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol 19:3091–3102

    PubMed  CAS  Google Scholar 

  • Dantonello TM, Int-Veen C, Harms D, Leuschner I, Schmidt BF, Herbst M, Juergens H, Scheel-Walter HG, Bielack SS, Klingebiel T, Dickerhoff R, Kirsch S, Brecht I, Schmelzle R, Greulich M, Gadner H, Greiner J, Marky I, Treuner J, Koscielniak E (2009) Cooperative trial CWS-91 for localized soft tissue sarcoma in children, adolescents, and young adults. J Clin Oncol 27:1446–1455

    Article  PubMed  CAS  Google Scholar 

  • Dasgupta R, Rodeberg DA (2012) Update on rhabdomyosarcoma. Semin Pediatr Surg 21:68–78

    Article  PubMed  Google Scholar 

  • De CF, Dall’Igna P, Bisogno G, Casara D, Rossi CR, Foletto M, Alaggio R, Carli M, Cecchetto G (2009) Sentinel node biopsy in pediatric soft tissue sarcomas of extremities. Pediatr Blood Cancer 52:51–54

    Article  Google Scholar 

  • Donaldson SS, Meza J, Breneman JC, Crist WM, Laurie F, Qualman SJ, Wharam M (2001) Results from the IRS-IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma–a report from the IRSG. Int J Radiat Oncol Biol Phys 51:718–728

    Article  PubMed  CAS  Google Scholar 

  • Fernandez-Pineda I, Spunt SL, Parida L, Krasin MJ, Davidoff AM, Rao BN (2011) Vaginal tumors in childhood: the experience of St. Jude Children’s Research Hospital. J Pediatr Surg 46:2071–2075

    Article  PubMed  Google Scholar 

  • Ferrari A, Orbach D, Sultan I, Casanova M, Bisogno G (2012) Neonatal soft tissue sarcomas. Semin Fetal Neonatal Med 17:231–238

    Article  PubMed  Google Scholar 

  • Frassica FJ, Khanna JA, McCarthy EF (2000) The role of MR imaging in soft tissue tumor evaluation: perspective of the orthopedic oncologist and musculoskeletal pathologist. Magn Reson Imaging Clin N Am 8:915–927

    PubMed  CAS  Google Scholar 

  • Fuchs J (2012) Solide Tumoren im Kindesalter; Grundlagen-Diagnostik-Therapie. Schattauer, Stuttgart

    Google Scholar 

  • Fuchs J, Dantonello TM, Blumenstock G, Kosztyla D, Klingenbiel T, Leuschner J, Schneck A, Nigyli F, Koscielniak E, Seitz G (2013) Treatment and outcome of patients suffering from pineal/perianal rhabdomyosarcoma – results from the CWS trials. Am Surg (in press)

    Google Scholar 

  • Haie-Meder C, Martelli H, Dumas I, Mazeron R, Oberlin O (2011) Brachytherapy in paediatric sarcoma. Bull Cancer 98:549–557

    PubMed  Google Scholar 

  • Hayes-Jordan A (2012) Recent advances in non-rhabdomyosarcoma soft-tissue sarcomas. Semin Pediatr Surg 21:61–67

    Article  PubMed  Google Scholar 

  • Hayes-Jordan A, Anderson PM (2011) The diagnosis and management of desmoplastic small round cell tumor: a review. Curr Opin Oncol 23:385–389

    Article  PubMed  Google Scholar 

  • Hayes-Jordan A, Andrassy R (2009) Rhabdomyosarcoma in children. Curr Opin Pediatr 21:373–378

    Article  PubMed  Google Scholar 

  • Hayes-Jordan A, Green H, Ludwig J, Anderson P (2012) Toxicity of hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric patients with sarcomatosis/carcinomatosis: Early experience and phase 1 results. Pediatr Blood Cancer 59:395–397

    Article  PubMed  CAS  Google Scholar 

  • Hayes-Jordan A, Stoner JA, Anderson JR, Rodeberg D, Weiner G, Meyer WH, Hawkins DS, Arndt CA, Paidas C (2008) The impact of surgical excision in chest wall rhabdomyosarcoma: a report from the Children’s Oncology Group. J Pediatr Surg 43:831–836

    Article  PubMed  Google Scholar 

  • Heinzelmann F, Thorwarth D, Lamprecht U, Kaulich TW, Fuchs J, Seitz G, Ebinger M, Handgretinger R, Bamberg MWeinmann M (2011) Comparison of different adjuvant radiotherapy approaches in childhood bladder/prostate rhabdomyosarcoma treated with conservative surgery. Strahlenther Onkol 187:715–721

    Article  PubMed  Google Scholar 

  • Klingebiel T, Boos J, Beske F, Hallmen E, Int-Veen C, Dantonello T, Treuner J, Gadner H, Marky I, Kazanowska BKoscielniak E (2008) Treatment of children with metastatic soft tissue sarcoma with oral maintenance compared to high dose chemotherapy: report of the HD CWS-96 trial. Pediatr Blood Cancer 50:739–745

    Article  PubMed  Google Scholar 

  • Koscielniak E, Morgan M, Treuner J (2002) Soft tissue sarcoma in children: prognosis and management. Paediatr Drugs 4:21–28

    PubMed  Google Scholar 

  • Magnusson S, Gisselsson D, Wiebe T, Kristoffersson U, Borg A, Olsson H (2012) Prevalence of germline TP53 mutations and history of Li-Fraumeni syndrome in families with childhood adrenocortical tumors, choroid plexus tumors, and rhabdomyosarcoma: A population-based survey. Pediatr Blood Cancer

    Google Scholar 

  • Malempati S, Hawkins DS (2012) Rhabdomyosarcoma: review of the Children’s Oncology Group (COG) Soft-Tissue Sarcoma Committee experience and rationale for current COG studies. Pediatr Blood Cancer 59:5–10

    Article  PubMed  Google Scholar 

  • Martelli H, Haie-Meder C, Branchereau S, Franchi-Abella S, Ghigna MR, Dumas I, Bouvet N, Oberlin O (2009) Conservative surgery plus brachytherapy treatment for boys with prostate and/or bladder neck rhabdomyosarcoma: a single team experience. J Pediatr Surg 44:190–196

    Article  PubMed  Google Scholar 

  • Martelli H, Oberlin O, Rey A, Godzinski J, Spicer RD, Bouvet N, Haie-Meder C, Terrier-Lacombe MJ, Sanchez de TJ, Spooner D, Sommelet D, Flamant FStevens MC (1999) Conservative treatment for girls with nonmetastatic rhabdomyosarcoma of the genital tract: A report from the Study Committee of the International Society of Pediatric Oncology. J Clin Oncol 17:2117–2122

    PubMed  CAS  Google Scholar 

  • Newton WA, Jr., Gehan EA, Webber BL, Marsden HB, van Unnik AJ, Hamoudi AB, Tsokos MG, Shimada H, Harms D, Schmidt D. (1995) Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification–an Intergroup Rhabdomyosarcoma Study. Cancer 76:1073–1085

    Article  PubMed  Google Scholar 

  • Oberlin O, Rey A, Sanchez de TJ, Martelli H, Jenney ME, Scopinaro M, Bergeron C, Merks JH, Bouvet N, Ellershaw C, Kelsey A, Spooner D, Stevens MC (2012) Randomized Comparison of Intensified Six-Drug Versus Standard Three-Drug Chemotherapy for High-Risk Nonmetastatic Rhabdomyosarcoma and Other Chemotherapy-Sensitive Childhood Soft Tissue Sarcomas: Long-Term Results From the International Society of Pediatric Oncology MMT95 Study. J Clin Oncol 30:2457–2465

    Article  PubMed  CAS  Google Scholar 

  • Parham DM, Webber BL, Jenkins JJ, Cantor AB, Maurer HM (1995) Nonrhabdomyosarcomatous soft tissue sarcomas of childhood: formulation of a simplified system for grading. Mod Pathol 8:705–710

    PubMed  CAS  Google Scholar 

  • Paulino AC (2004) Treatment options for children with nonrhabdomyosarcoma soft tissue sarcoma. Expert Rev Anticancer Ther 4:247–256

    Article  PubMed  CAS  Google Scholar 

  • Perez EA, Kassira N, Cheung MC, Koniaris LG, Neville HL, Sola JE (2011) Rhabdomyosarcoma in children: a SEER population based study. J Surg Res 170:e243–e251

    Google Scholar 

  • Raney B, Anderson J, Jenney M, Arndt C, Brecht I, Carli M, Bisogno G, Oberlin O, Rey A, Treuner J, Ullrich F, Stevens M (2006) Late effects in 164 patients with rhabdomyosarcoma of the bladder/prostate region: a report from the international workshop. J Urol 176:2190–2194

    Article  PubMed  Google Scholar 

  • Reinhard H, Reinert J, Beier R, Furtwangler R, Alkasser M, Rutkowski S, Fruhwald M, Koscielniak E, Leuschner I, Kaatsch P, Graf N (2008) Rhabdoid tumors in children: prognostic factors in 70 patients diagnosed in Germany. Oncol Rep 19:819–823

    PubMed  Google Scholar 

  • Rodeberg DA, Anderson JR, Arndt CA, Ferrer FA, Raney RB, Jenney ME, Brecht IB, Koscielniak E, Carli M, Bisogno G, Oberlin O, Rey A, Ullrich F, Stevens MC, Meyer WH (2011) Comparison of outcomes based on treatment algorithms for rhabdomyosarcoma of the bladder/prostate: combined results from the Children’s Oncology Group, German Cooperative Soft Tissue Sarcoma Study, Italian Cooperative Group, and International Society of Pediatric Oncology Malignant Mesenchymal Tumors Committee. Int J Cancer 128:1232–1239

    Article  PubMed  CAS  Google Scholar 

  • Rodeberg DA, Paidas CN, Lobe TL, Brown K, Andrassy RJ, Crist WM, Wiener ES (2002) Surgical Principles for Children/Adolescents With Newly Diagnosed Rhabdomyosarcoma: A Report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group. Sarcoma 6:111–122

    Article  PubMed  Google Scholar 

  • Schalow ELBroecker BH (2003) Role of surgery in children with rhabdomyosarcoma. Med Pediatr Oncol 41:1–6

    Article  Google Scholar 

  • Seitz G, Dantonello TM, Int-Veen C, Blumenstock G, Godzinski J, Klingebiel T, Schuck A, Leuschner I, Koscielniak E, Fuchs J (2011) Treatment efficiency, outcome and surgical treatment problems in patients suffering from localized embryonal bladder/prostate rhabdomyosarcoma: a report from the Cooperative Soft Tissue Sarcoma trial CWS-96. Pediatr Blood Cancer 56:718–724

    Article  PubMed  Google Scholar 

  • Sobin LH (2009) UICC:TNM classification of malignant tumors. Wiley

    Google Scholar 

  • Walter F, Czernin J, Hall T, Allen-Auerbach M, Walter MA, Dunkelmann S, Federman N (2012) Is there a need for dedicated bone imaging in addition to 18F-FDG PET/CT imaging in pediatric sarcoma patients? J Pediatr Hematol Oncol 34:131–136

    Article  PubMed  CAS  Google Scholar 

  • Walterhouse DO, Meza JL, Breneman JC, Donaldson SS, Hayes-Jordan A, Pappo AS, Arndt C, Raney RB, Meyer WH, Hawkins DS (2011) Local control and outcome in children with localized vaginal rhabdomyosarcoma: a report from the Soft Tissue Sarcoma committee of the Children’s Oncology Group. Pediatr Blood Cancer 57:76–83

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universitätsklinik für Kinder- und JugendmedizinEberhard Karls Universität, TübingenHoppe-Seyler-Straße, 372076, Tübingen, Deutschland

    J. Fuchs

Authors
  1. J. Fuchs
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Kinderchirurgische Klinik, Universitätsklinikum München Dr. von Haunersches Kinderspital, München, Germany

    Dietrich von Schweinitz

  2. Abt. Kinderchirurgie, Medizinische Hochschule Hannover (MHH) Kinderklinik, Hannover, Germany

    Benno Ure

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Fuchs, J. (2013). Weichteiltumoren. In: von Schweinitz, D., Ure, B. (eds) Kinderchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29779-3_48

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-29779-3_48

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-29778-6

  • Online ISBN: 978-3-642-29779-3

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation