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Fetale Infektionen

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Ultraschalldiagnostik in Geburtshilfe und Gynäkologie

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Zusammenfassung

Trotz aller Fortschritte in der Ultraschalltechnologie resultieren die Verbesserungen der fetalen Infektionsdiagnostik vor allem aus den innovativen serologischen und molekulargenetischen Labormethoden. Diese Neuerungen haben die pränatalen diagnostischen und therapeutischen Strategien in den letzten zwei Jahrzehnten erheblich beeinflusst und ermöglichen in Kenntnis der unterschiedlichen Sensitivitäten und Spezifitäten der jeweiligen Labornachweismethoden (PCR, Viruskultur, etc.) aus Fruchtwasser, fetalem Aszites oder fetalen Pleuraergüssen zunehmend risikoärmere fetal-invasive Verfahren mit nur noch selten erforderlichen direkten fetalen Blutentnahmen (Banatvala u. Brown 2004, Benoist et al. 2008, Bonvicini et al. 2009, Enders et al. 2010, Goegebuer et al. 2009, Groß et al. 2001, Guerra et al. 2008, Montoya u. Remington 2008, Signorell et al. 2006, Syridou et al. 2008, Wandinger et al. 2011, Tab. 25.1).

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Literatur

  • Adler SP, Nigro G (2009) Findings and conclusions from CMV hyperimmune globulin treatment trials. J Clin Virol 46(Suppl 4):S54–S57

    Article  PubMed  Google Scholar 

  • Banatvala JE, Brown DW (2004) Rubella. Lancet 363(9415):1127–1137

    Article  CAS  PubMed  Google Scholar 

  • Bekhit MT, Greenwood PA, Warren R, Aarons E, Jauniaux E (2009) In utero treatment of severe fetal anaemia due to parvovirus B19 in one fetus in a twin pregnancy – a case report and literature review. Fetal Diagn Ther 25(1):153–157

    Article  CAS  PubMed  Google Scholar 

  • Benoist G, Salomon LJ, Jacquemard F, Daffos F, Ville Y (2008) The prognostic value of ultrasound abnormalities and biological parameters in blood of fetuses infected with cytomegalovirus. BJOG Jun 115(7):823–829

    Article  CAS  Google Scholar 

  • Benoist G, Leruez-Ville M, Magny JF, Jacquemard F, Salomon LJ, Ville Y (2013) Management of Pregnancies with Confirmed Cytomegalovirus Fetal Infection. Fetal Diagn Ther 33:203–214

    Article  PubMed  Google Scholar 

  • Bessières MH, Berrebi A, Cassaing S, Fillaux J, Cambus JP, Berry A, Assouline C, Ayoubi JM, Magnaval JF (2009) Diagnosis of congenital toxoplasmosis: prenatal and neonatal evaluation of methods used in Toulouse University Hospital and incidence of congenital toxoplasmosis. Mem Inst Oswaldo Cruz 104(2):389-392

    Article  PubMed  Google Scholar 

  • Best JM, O’Shea S, Tipples G, Davies N, Al-Khusaiby SM, Krause A, Hesketh LM, Jin L, Enders G (2002) Interpretation of rubella serology in pregnancy – pitfalls and problems. BMJ 325:147–148

    Article  PubMed  PubMed Central  Google Scholar 

  • Bonvicini F, Manaresi E, Gallinella G, Gentilomi GA, Musiani M, Zerbini M (2009) Diagnosis of fetal parvovirus B19 infection: value of virological assays in fetal specimens. BJOG 116(6):813–817

    Article  CAS  PubMed  Google Scholar 

  • Cannon MJ, Schmid DS, Hyde TB (2010) Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol 20(4):202–213

    Article  PubMed  Google Scholar 

  • Cheeran MC, Lokensgard JR, Schleiss MR (2009) Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention. Clin Microbiol Rev 22(1):99–126

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Christoph J, Kattner E, Seitz HM, Reiter-Owona I (2004) Strategies for the diagnosis and treatment of prenatal toxoplasmosis – a survey. Z Geburtshilfe Neonatol 208:10–16

    Article  CAS  PubMed  Google Scholar 

  • Coll O, Benoist G, Ville Y, Weisman LE, Botet F, Anceschi MM, Greenough A, Gibbs RS, Carbonell-Estrany X (2009) Guidelines on CMV congenital infection. J Perinat Med 37(5):433–445

    Article  PubMed  Google Scholar 

  • Enders G, Calm A, Schaub J (1984) Rubella embryopathy after previous maternal rubella vaccination Infection. Mar–Apr 12(2):96–8

    CAS  Google Scholar 

  • Enders G, Daiminger A, Bäder U, Exler S, Enders M (2011) Intrauterine transmission and clinical outcome of 248 pregnancies with primary cytomegalovirus infection in relation to gestational age. J Clin Virol 52(3):244-246

    Article  PubMed  Google Scholar 

  • Enders M, Klingel K, Weidner A, Baisch C, Kandolf R, Schalasta G, Enders G (2010) Risk of fetal hydrops and non-hydropic late intrauterine fetal death after gestational parvovirus B19 infection. J Clin Virol 49(3):163–168

    Article  PubMed  Google Scholar 

  • Enders G, Miller E, Cradock-Watson J, Bolley I, Ridehalgh M. (1994) Consequences of varicella and herpes zoster in pregnancy: prospective study of 1739 cases. Lancet.18;343(8912):1548-51

    Article  Google Scholar 

  • Enders M, Weidner A, Zoellner I, Searle K, Enders G (2004) Fetal morbidity and mortality after acute human parvovirus B19 infection in pregnancy: prospective evaluation of 1018 cases. Prenat Diagn 24(7):513–518

    Article  PubMed  Google Scholar 

  • Enders G (2005) Akzidentelle Rötelnschutzimpfungen um den Zeitpunkt der Konzeption und in der Frühschwangerschaft Bundesgesundheitsblatt–Gesundheitsforschung–Gesundheitsschutz. Springer Medizin Verlag, Berlin

    Google Scholar 

  • Foulon W, Pinon JM, Stray-Pedersen B, Pollak A, Lappalainen M, Decoster A, Villena I, Jenum PA, Hayde M, Naessens A (1999) Prenatal diagnosis of congenital toxoplasmosis: a multicenter evaluation of different diagnostic parameters. Am J Obstet Gynecol 181(4):843-847

    Article  CAS  PubMed  Google Scholar 

  • Gärtner B, Enders M, Luft-Duchow C, Bocharov G, Modorow S (2007) Parvovirus-B19-Infektionen bei Schwangeren in der Kinderbetreuung Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz 50: 1369. Springer Medizin Verlag, Berlin

    Google Scholar 

  • Goegebuer T, Van Meensel B, Beuselinck K, Cossey V, Van Ranst M, Hanssens M, Lagrou K (2009) Clinical predictive value of real-time PCR quantification of human cytomegalovirus DNA in amniotic fluid samples. J Clin Microbiol 47(3):660–665

    Article  CAS  PubMed  Google Scholar 

  • Groß U (2004) Prävalenz und Public-Health-Aspekte der Toxoplasmose. Bundesgesundheitsblatt 47:692–697

    Google Scholar 

  • Groß U, Roos T, Friese K (2001) Toxoplasmose in der Schwangerschaft. Dt Ärzteblatt 98:A 3293–A 3300

    Google Scholar 

  • Guerra B, Simonazzi G, Puccetti C, Lanari M, Farina A, Lazzarotto T, Rizzo N (2008) Ultrasound prediction of symptomatic congenital cytomegalovirus infection. Am J Obstet Gynecol 198:380.e1–380.e7

    Article  Google Scholar 

  • Hamprecht K, Jahn G (2007) Human cytomegalovirus and congenital virus infection. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50(11):1379–1392

    Article  CAS  PubMed  Google Scholar 

  • Hamprecht K, Maschmann J, Jahn G, Poets CF, Goelz R (2008) Cytomegalovirus transmission to preterm infants during lactation. J Clin Virol 41(3):198–205

    Article  PubMed  Google Scholar 

  • Hohlfeld P, Daffos F, Costa JM, Thulliez P, Forestier F, Vidaud M (1994) Prenatal diagnosis of congenital toxoplasmosis with a polymerase-chain-reaction test on amniotic fluid. N Engl J Med 331:695–699

    Article  CAS  PubMed  Google Scholar 

  • Kakoulidou M, Forsgren M, Lewensohn-Fuchs I, Johansen K (2010) Serum levels of rubella-specific antibodies in Swedish women following three decades of vaccination programmes. Vaccine 28(4):1002–1007

    Article  CAS  PubMed  Google Scholar 

  • Lamont RF, Sobel JD, Vaisbuch EB, Kusanovic JP, Mazaki-Tovi S, Kim SK, Uldbjerg N, Romero R (2011) Parvovirus B19 infection in human pregnancy. BJOG 118:175–186

    Article  CAS  PubMed  Google Scholar 

  • Lazzarotto T, Guerra B, Lanari M, Gabrielli L, Landini MP (2008) New advances in the diagnosis of congenital cytomegalovirus infection. J Clin Virol 41(3):192–197

    Article  CAS  PubMed  Google Scholar 

  • Montoya JG, Remington JS (2008) Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis 47(4):554–566

    Article  PubMed  Google Scholar 

  • Munro ND, Sheppard S, Smithells RW, Holzel H, Jones G (1987) Temporal relations between maternal rubella and congenital defects. Lancet 2(8552):201–204

    Article  CAS  PubMed  Google Scholar 

  • Mylonas I, Gutsche S, Anton G, Jeschke U, Weissenbacher ER, Friese K (2007) Parvovirus-B19-Infektion in der Schwangerschaft. Z Geburtsh Neonatol 211:60–68

    Article  CAS  Google Scholar 

  • Nagel HT, de Haan TR, Vandenbussche FP, Oepkes D, Walther FJ (2007) Long-term outcome after fetal transfusion for hydrops associated with parvovirus B19 infection. Obstet Gynecol 109(1):42–47

    Article  PubMed  Google Scholar 

  • Nigro G, Adler SP, La Torre R, Best AM (2005) Passive immunization during pregnancy for congenital cytomegalovirus infection. Congenital Cytomegalovirus Collaborating Group. N Engl J Med 353(13):1350–1362

    Article  CAS  PubMed  Google Scholar 

  • Nigro G, Torre RL, Pentimalli H, Taverna P, Lituania M, de Tejada BM, Adler SP (2008) Regression of fetal cerebral abnormalities by primary cytomegalovirus infection following hyperimmunoglobulin therapy. Prenat Diagn 28(6):512–517

    Article  PubMed  Google Scholar 

  • Pass RF, Zhang C, Evans A, Simpson T, Andrews W, Huang ML, Corey L, Hill J, Davis E, Flanigan C, Cloud G (2009) Vaccine prevention of maternal cytomegalovirus infection. N Engl J Med 360(12):1191–1199

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Picone O, Simon I, Benachi A, Brunelle F, Sonigo P (2008) Comparison between ultrasound and magnetic resonance imaging in assessment of fetal cytomegalovirus infection. Prenat Diagn 28(8):753–758

    Article  PubMed  Google Scholar 

  • Pratlong F, Boulot P, Villena I, Issert E, Tamby I, Cazenave J, Dedet JP (1996) Antenatal diagnosis of congenital toxoplasmosis: evaluation of the biological parameters in a cohort of 286 patients. Br J Obstet Gynaecol 103(6):552-557

    Article  CAS  PubMed  Google Scholar 

  • Pretlove SJ, Fox CE, Khan KS, Kilby MD (2009) Noninvasive methods of detecting fetal anaemia: a systematic review and meta-analysis. BJOG 116(12):1558–1567

    Article  CAS  PubMed  Google Scholar 

  • Romand S, Wallon M, Franck J, Thulliez P, Peyron F, Dumon H (2001) Prenatal diagnosis using polymerase chain reaction on amniotic fluid for congenital toxoplasmosis. Obstet Gynecol 97(2):296-300

    CAS  PubMed  Google Scholar 

  • Sanchez MA, Bello-Munoz JC, Cebrecos I, Sanz TH, Martinez JS, Moratonas EC, Roura LC (2011) The prevalence of congenital varicella syndrome after a maternal infection, but before 20 weeks of pregnancy: a prospective cohort study. J Matern Fetal Neonatal Med 24(2):341–347

    Article  PubMed  Google Scholar 

  • Shields KE, Galil K, Seward J, Sharrar RG, Cordero JF, Slater E (2001) Varicella vaccine exposure during pregnancy: data from the first 5 years of the pregnancy registry. Obstet Gynecol 98(1):14–19

    CAS  PubMed  Google Scholar 

  • Signorell LM, Seitz D, Merkel S, Berger R, Rudin C (2006) Cord blood screening for congenital toxoplasmosis in northwestern Switzerland, 1982–1999. Pediatr Infect Dis J 25(2):123–128

    Article  PubMed  Google Scholar 

  • Stelma FF, Smismans A, Goossens VJ, Bruggeman CA, Hoebe CJ (2009) Occupational risk of human Cytomegalovirus and Parvovirus B19 infection in female day care personnel in the Netherlands a study based on seroprevalence. Eur J Clin Microbiol Infect Dis 28(4):393–397

    Article  CAS  PubMed  Google Scholar 

  • Syridou G, Spanakis N, Konstantinidou A, Piperaki ET, Kafetzis D, Patsouris E, Antsaklis A, Tsakris A (2008) Detection of cytomegalovirus, parvovirus B19 and herpes simplex viruses in cases of intrauterine fetal death: association with pathological findings. J Med Virol 80(10):1776–1782

    Article  PubMed  Google Scholar 

  • Thiébaut R, Leproust S, Chêne G, Gilbert R, SYROCOT (Systematic Review on Congenital Toxoplasmosis) study group (2007) Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients’ data. Lancet 369(9556):115–122

    Article  PubMed  Google Scholar 

  • Ushida M, Katow S, Furukawa S (2003) Congenital rubella syndrome due to infection after maternal antibody conversion with vaccine. Jpn J Infect Dis 56(2):68–69

    PubMed  Google Scholar 

  • Vauloup-Fellous C, Hübschen JM, Abernathy ES, Icenogle J, Gaidot N, Dubreuil P, Parent-du-Châtelet I, Grangeot-Keros L, Muller CP (2010) Phylogenetic analysis of rubella viruses involved in congenital rubella infections in France between 1995 and 2009. J Clin Microbiol 48(7):2530–2535

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vauloup-Fellous C, Picone O, Cordier AG, Parent-du-Châtelet I, Senat MV, Frydman R, Grangeot-Keros L (2009) Does hygiene counseling have an impact on the rate of CMV primary infection during pregnancy? Results of a 3-year prospective study in a French hospital. J Clin Virol 46(Suppl 4):S49–S53

    Article  PubMed  Google Scholar 

  • Verstraelen H, Vanzieleghem B, Defoort P, Vanhaesebrouck P, Temmerman M (2003) Prenatal ultrasound and magnetic resonance imaging in fetal varicella syndrome: correlation with pathology findings. Prenat Diagn 23(9):705–709

    Article  PubMed  Google Scholar 

  • Villena I, Ancelle T, Delmas C, Garcia P, Brezin AP, Thulliez P, Wallon M, King L, Goulet V (2010) Toxosurv network and National Reference Centre for Toxoplasmosis.Congenital toxoplasmosis in France in 2007: first results from a national surveillance system. Euro Surveill. Jun 24 15(25). pii: 19600

    Google Scholar 

  • Wallon M, Franck J, Thulliez P, Huissoud C, Peyron F, Garcia-Meric P, Kieffer F (2010) Accuracy of real-time polymerase chain reaction for Toxoplasma gondii in amniotic fluid. Obstet Gynecol 115(4):727-733

    Article  PubMed  Google Scholar 

  • Wandinger KP, Saschenbrecker S, Steinhagen K, Scheper T, Meyer W, Bartelt U, Enders G (2011) Diagnosis of recent primary rubella virus infections: Significance of glycoprotein-based IgM serology, IgG avidity and immunoblot analysis. J Virol Methods 174(1-2):85–93

    Article  CAS  PubMed  Google Scholar 

  • Wutzler P, Sauerbrei A (2007) Varizellen in der Schwangerschaft und bei Neugeborenen. Bundesgesundheitsblatt – Gesundheitsforschung – Gesundheitsschutz 50:237–244 (Springer Medizin Verlag)

    Article  PubMed  Google Scholar 

  • Yamamoto AY, Mussi-Pinhata MM, Boppana SB, Novak Z, Wagatsuma VM, Oliveira Pde F, Duarte G, Britt WJ (2010) Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population. Am J Obstet Gynecol 202(3):297.e1–297.e8

    Article  Google Scholar 

  • Yinon Y, Farine D, Yudin MH, Gagnon R, Hudon L, Basso M, Bos H, Delisle MF, Menticoglou S, Mundle W, Ouellet A, Pressey T, Roggensack A, Boucher M, Castillo E, Gruslin A, Money DM, Murphy K, Ogilvie G, Paquet C, Van Eyk N, van Schalkwyk J (2010) Cytomegalovirus infection in pregnancy. Fetal Medicine Committee, Society of Obstetricians and Gynaecologists of Canada. J Obstet Gynaecol Can 32(4):348–354

    Article  PubMed  Google Scholar 

  • Zalel Y, Gilboa Y, Berkenshtat M, Yoeli R, Auslander R, Achiron R, Goldberg Y (2008) Secondary cytomegalovirus infection can cause severe fetal sequelae despite maternal preconceptional immunity. Ultrasound Obstet Gynecol 31(4):417–420

    Article  CAS  PubMed  Google Scholar 

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  1. Zentrum für Ultraschall- und Pränataldiagnostik, Mathias-Spital Rheine, Frankenburgstraße 31, 48431, Rheine, Deutschland

    Matthias Meyer-Wittkopf Prof. Dr. med.

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  1. Matthias Meyer-Wittkopf Prof. Dr. med.
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Editors and Affiliations

  1. Frauenheilkunde, Universitätsklinikum Bonn Zentrum für Geburtshilfe und, Bonn, Germany

    Ulrich Gembruch

  2. Klinik für Geburtshilfe und Pränatalmedizin, Universitätsklinikum Hamburg Eppendorf, Hamburg, Germany

    Kurt Hecher

  3. Praxis f. Frauenhlkd. u. Pränataldiag., Salzburg, Austria

    Horst Steiner

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Meyer-Wittkopf, M. (2013). Fetale Infektionen. In: Gembruch, U., Hecher, K., Steiner, H. (eds) Ultraschalldiagnostik in Geburtshilfe und Gynäkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29633-8_25

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