A Model for Biased Fractionation after Whole Genome Duplication
Paralog reduction, the loss of duplicate genes after whole genome duplication (WGD), causes more gene order disruption than chromosomal rearrangements such as inversion or translocation. This is particularly true in flowering plants.
Whether the loss proceeds gene by gene or through deletion of multi-gene DNA segments is controversial, as is the question of fractionation bias, namely whether one of the two homeologous chromosomes is more vulnerable to deletion. The process is subject to the overriding functional constraint that only one gene copy can be deleted.