Abstract
This chapter builds on the basic principles of THz spectroscopy and explains how they can be applied to biomedical systems as well as the motivation for doing so. Sample preparation techniques and measurement methods for biomedical samples are described in detail. Examples of medical applications investigated hitherto including breast cancer and skin cancer are also presented.
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References
R.H. Clothier, N. Bourne, Effects of THz exposure on human primary keratinocyte differentiation and viability. J. Biol. Phys. 29, 179–85 (2003)
O. Zeni, G.P. Gallerano, A. Perrotta, M. Romano, A. Sannino, M. Sarti et al., Cytogenetic observations in human peripheral blood leukocytes following in vitro exposure to THz radiation: a pilot study. Health Phys. 92, 349–57 (2007)
S. Sy, S. Huang, Y.-X.J. Wang, J. Yu, A.T. Ahuja, Y. Zhang, E. Pickwell-MacPherson, Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast. Phys. Med. Biol. 55, 7587–7596 (2010)
P.C. Ashworth, E. Pickwell-Macpherson, E. Provenzano, S.E. Pinder, A.D. Purushotham, M.Pepper, and V.P. Wallace, Opt. Express 17, 12444 (2009).
S. Huang, P.C. Ashworth, K.W.C. Kan, C. Yang, V.P. Wallace, Y. Zhang, E. Pickwell-MacPherson, Improved sample characterization in terahertz reflection imaging and spectroscopy. Opt. Express 17(5), 3848–3854 (2009)
S.Y. Huang, Y.X. Wang, K.W. Yeung, A.T. Ahuja, Y.-T. Zhang, E. Pickwell-MacPherson, Tissue characterisation using terahertz pulsed imaging in reflection geometry. Phys. Med. Biol. 54, 149–160 (2009)
E. Pickwell, V.P. Wallace, Biomedical applications of THz technology. J. Phys. D Appl. Phys. 39, R301–R310 (2006)
E. Pickwell-MacPherson, V.P. Wallace, Terahertz pulsed imaging—a potential medical imaging modality? Photodiagn. Photodyn. Ther. 62, 128–134 (2009)
E. Pickwell-MacPherson, Practical considerations for in vivo THz imaging. J. Terahertz Sci. Technol. 3(4), 163–171 (2010)
A.J. Fitzgerald, V.P. Wallace, M. Jimenez-Linan, L. Bobrow, R.J. Pye, A.D. Purushotham, D.D. Arnone, Terahertz pulsed imaging of human breast tumors. Radiology 239, 533–540 (2006)
P.C. Ashworth, E. Pickwell-MacPherson, S.E. Pinder, E. Provenzano, A.D. Purushotham, M. Pepper, V.P. Wallace, Terahertz pulsed spectroscopy of freshly excised human breast cancer. Opt. Express 17(15), 12444–54 (2009)
V.P. Wallace, A.J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, D.D. Arnone, Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo. Br. J. Dermatol. 151, 424–432 (2004)
V.P. Wallace, A.J. Fitzgerald, E. Pickwell, R.J. Pye, P.F. Taday, N. Flanagand, T. Ha, Terahertz pulsed spectroscopy of human basal cell carcinoma. J. Appl. Spectrosc. 60(10), 1127–1133 (2006)
E. Pickwell, B.E. Cole, A.J. Fitzgerald, V.P. Wallace, M. Pepper, Simulation of terahertz pulse propagation in biological systems. Appl. Phys. Lett. 84(12), 2190–2192 (2004)
E. Pickwell, V.P. Wallace, A.J. Fitzgerald, B.E. Cole, R.J. Pye, T. Ha, M. Pepper, Simulating the response of terahertz radiation to human skin using ex vivo spectroscopy measurements. J. Biomed. Opt. 10(6), 064021-1–064021-7 (2005)
V.P. Wallace, Terahertz imaging detects cancerous tissue. SPIE Newsroom, 16 Dec 2008. http://spie.org/x32216.xml?ArticleID=x32216
D.A. Crawley, C. Longbottom, B.E. Cole, C.M. Ciesla, D. Arnone, V.P. Wallace, M. Pepper, Terahertz pulse imaging: a pilot study of potential applications in dentistry. Caries Res. 37, 352–359 (2003)
E. Pickwell, V.P. Wallace, B.E. Cole, S. Ali, C. Longbottom, R. Lynch, M. Pepper, A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro. Caries Res. 41(4955), 2007 (2007)
E. Pickwell-MacPherson, S.Y. Huang, Y. Sun, W.C. Kan, Y.T. Zhang, Terahertz image processing methods for biomedical applications. in Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vancouver 2008
B.E. Cole, R.M. Woodward, D. Crawley, V.P. Wallace, D.D. Arnone, M. Pepper, Terahertz imaging and spectroscopy of human skin, in vivo. SPIE Proc. 2001(4276), 1–10 (2001)
E. Pickwell, B.E. Cole, A.J. Fitzgerald, M. Pepper, V.P. Wallace, In vivo study of human skin using pulsed terahertz radiation. Phys. Med. Biol. 49, 1595–1607 (2004)
S.Y. Huang, E. Pickwell-MacPherson, Y.T. Zhang, A Feasibility Study of Burn Wound Depth Assessment Using Terahertz Pulsed Imaging (IEEE-EMBS International Summer School and Symposium on Medical Devices and Biosensors, Cambridge, 2007)
Z.D. Taylor, R.S. Singh, M.O. Culjat, J.Y. Suen, W.S. Grundfest, H. Lee, E.R. Brown, Reflective terahertz imaging of porcine skin burns. Opt. Lett. 33(11), 1258–60 (2008 Jun 1)
C.S. Joseph, A.N. Yaroslavsky, M. Al-Arashi, T.M. Goyette, J.C. Dickinson, A.J. Gatesman, B.W. Soper, C.M. Forgione, T.M. Horgan, E.J. Ehasz, R.H. Giles, W.E. Nixon, Terahertz spectroscopy of intrinsic biomarkers for non-melanoma skin cancer. Proc. SPIE 7215, 72150I (2009)
Y. Sun, Y. Zhang, E. Pickwell-MacPherson, Investigating antibody interactions with polar liquids using terahertz pulsed spectroscopy. Biophys. J. 100(1), 225–231 (2010)
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MacPherson, E. (2012). Biomedical Imaging. In: Peiponen, KE., Zeitler, A., Kuwata-Gonokami, M. (eds) Terahertz Spectroscopy and Imaging. Springer Series in Optical Sciences, vol 171. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29564-5_16
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DOI: https://doi.org/10.1007/978-3-642-29564-5_16
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