Skip to main content

Biomedical Imaging

  • Chapter
  • First Online:
Terahertz Spectroscopy and Imaging

Part of the book series: Springer Series in Optical Sciences ((SSOS,volume 171))

  • 6128 Accesses

Abstract

This chapter builds on the basic principles of THz spectroscopy and explains how they can be applied to biomedical systems as well as the motivation for doing so. Sample preparation techniques and measurement methods for biomedical samples are described in detail. Examples of medical applications investigated hitherto including breast cancer and skin cancer are also presented.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. R.H. Clothier, N. Bourne, Effects of THz exposure on human primary keratinocyte differentiation and viability. J. Biol. Phys. 29, 179–85 (2003)

    Article  Google Scholar 

  2. O. Zeni, G.P. Gallerano, A. Perrotta, M. Romano, A. Sannino, M. Sarti et al., Cytogenetic observations in human peripheral blood leukocytes following in vitro exposure to THz radiation: a pilot study. Health Phys. 92, 349–57 (2007)

    Article  Google Scholar 

  3. S. Sy, S. Huang, Y.-X.J. Wang, J. Yu, A.T. Ahuja, Y. Zhang, E. Pickwell-MacPherson, Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast. Phys. Med. Biol. 55, 7587–7596 (2010)

    Google Scholar 

  4. P.C. Ashworth, E. Pickwell-Macpherson, E. Provenzano, S.E. Pinder, A.D. Purushotham, M.Pepper, and V.P. Wallace, Opt. Express 17, 12444 (2009).

    Google Scholar 

  5. S. Huang, P.C. Ashworth, K.W.C. Kan, C. Yang, V.P. Wallace, Y. Zhang, E. Pickwell-MacPherson, Improved sample characterization in terahertz reflection imaging and spectroscopy. Opt. Express 17(5), 3848–3854 (2009)

    Article  ADS  Google Scholar 

  6. S.Y. Huang, Y.X. Wang, K.W. Yeung, A.T. Ahuja, Y.-T. Zhang, E. Pickwell-MacPherson, Tissue characterisation using terahertz pulsed imaging in reflection geometry. Phys. Med. Biol. 54, 149–160 (2009)

    Article  Google Scholar 

  7. E. Pickwell, V.P. Wallace, Biomedical applications of THz technology. J. Phys. D Appl. Phys. 39, R301–R310 (2006)

    Article  ADS  Google Scholar 

  8. E. Pickwell-MacPherson, V.P. Wallace, Terahertz pulsed imaging—a potential medical imaging modality? Photodiagn. Photodyn. Ther. 62, 128–134 (2009)

    Google Scholar 

  9. E. Pickwell-MacPherson, Practical considerations for in vivo THz imaging. J. Terahertz Sci. Technol. 3(4), 163–171 (2010)

    Google Scholar 

  10. A.J. Fitzgerald, V.P. Wallace, M. Jimenez-Linan, L. Bobrow, R.J. Pye, A.D. Purushotham, D.D. Arnone, Terahertz pulsed imaging of human breast tumors. Radiology 239, 533–540 (2006)

    Article  Google Scholar 

  11. P.C. Ashworth, E. Pickwell-MacPherson, S.E. Pinder, E. Provenzano, A.D. Purushotham, M. Pepper, V.P. Wallace, Terahertz pulsed spectroscopy of freshly excised human breast cancer. Opt. Express 17(15), 12444–54 (2009)

    Article  ADS  Google Scholar 

  12. V.P. Wallace, A.J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, D.D. Arnone, Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo. Br. J. Dermatol. 151, 424–432 (2004)

    Article  Google Scholar 

  13. V.P. Wallace, A.J. Fitzgerald, E. Pickwell, R.J. Pye, P.F. Taday, N. Flanagand, T. Ha, Terahertz pulsed spectroscopy of human basal cell carcinoma. J. Appl. Spectrosc. 60(10), 1127–1133 (2006)

    Article  ADS  Google Scholar 

  14. E. Pickwell, B.E. Cole, A.J. Fitzgerald, V.P. Wallace, M. Pepper, Simulation of terahertz pulse propagation in biological systems. Appl. Phys. Lett. 84(12), 2190–2192 (2004)

    Article  ADS  Google Scholar 

  15. E. Pickwell, V.P. Wallace, A.J. Fitzgerald, B.E. Cole, R.J. Pye, T. Ha, M. Pepper, Simulating the response of terahertz radiation to human skin using ex vivo spectroscopy measurements. J. Biomed. Opt. 10(6), 064021-1–064021-7 (2005)

    Google Scholar 

  16. V.P. Wallace, Terahertz imaging detects cancerous tissue. SPIE Newsroom, 16 Dec 2008. http://spie.org/x32216.xml?ArticleID=x32216

  17. D.A. Crawley, C. Longbottom, B.E. Cole, C.M. Ciesla, D. Arnone, V.P. Wallace, M. Pepper, Terahertz pulse imaging: a pilot study of potential applications in dentistry. Caries Res. 37, 352–359 (2003)

    Article  Google Scholar 

  18. E. Pickwell, V.P. Wallace, B.E. Cole, S. Ali, C. Longbottom, R. Lynch, M. Pepper, A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro. Caries Res. 41(4955), 2007 (2007)

    Google Scholar 

  19. E. Pickwell-MacPherson, S.Y. Huang, Y. Sun, W.C. Kan, Y.T. Zhang, Terahertz image processing methods for biomedical applications. in Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vancouver 2008

    Google Scholar 

  20. B.E. Cole, R.M. Woodward, D. Crawley, V.P. Wallace, D.D. Arnone, M. Pepper, Terahertz imaging and spectroscopy of human skin, in vivo. SPIE Proc. 2001(4276), 1–10 (2001)

    Article  Google Scholar 

  21. E. Pickwell, B.E. Cole, A.J. Fitzgerald, M. Pepper, V.P. Wallace, In vivo study of human skin using pulsed terahertz radiation. Phys. Med. Biol. 49, 1595–1607 (2004)

    Article  Google Scholar 

  22. S.Y. Huang, E. Pickwell-MacPherson, Y.T. Zhang, A Feasibility Study of Burn Wound Depth Assessment Using Terahertz Pulsed Imaging (IEEE-EMBS International Summer School and Symposium on Medical Devices and Biosensors, Cambridge, 2007)

    Google Scholar 

  23. Z.D. Taylor, R.S. Singh, M.O. Culjat, J.Y. Suen, W.S. Grundfest, H. Lee, E.R. Brown, Reflective terahertz imaging of porcine skin burns. Opt. Lett. 33(11), 1258–60 (2008 Jun 1)

    Article  Google Scholar 

  24. C.S. Joseph, A.N. Yaroslavsky, M. Al-Arashi, T.M. Goyette, J.C. Dickinson, A.J. Gatesman, B.W. Soper, C.M. Forgione, T.M. Horgan, E.J. Ehasz, R.H. Giles, W.E. Nixon, Terahertz spectroscopy of intrinsic biomarkers for non-melanoma skin cancer. Proc. SPIE 7215, 72150I (2009)

    Article  ADS  Google Scholar 

  25. Y. Sun, Y. Zhang, E. Pickwell-MacPherson, Investigating antibody interactions with polar liquids using terahertz pulsed spectroscopy. Biophys. J. 100(1), 225–231 (2010)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Emma MacPherson .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

MacPherson, E. (2012). Biomedical Imaging. In: Peiponen, KE., Zeitler, A., Kuwata-Gonokami, M. (eds) Terahertz Spectroscopy and Imaging. Springer Series in Optical Sciences, vol 171. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29564-5_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-29564-5_16

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-29563-8

  • Online ISBN: 978-3-642-29564-5

  • eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)

Publish with us

Policies and ethics