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Molecular Aspects of Hematologic Malignancies pp 217–235Cite as

Allogeneic Transplantation of Hematopoietic Stem Cells

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Part of the book series: Principles and Practice ((PRINCIPLES))

Abstract

Molecular and cytometric studies of human hematopoietic stem cells and its microenvironment have greatly contributed to a better understanding of their biology, including regulation of their function and mutual interaction. This has resulted in the improvements of the procedure of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for hematological malignancies. In addition, molecular and cytometric studies enable better recognition of the pathology of toxic, immunological, and infectious complications related to allo-HSCT as well as better monitoring of post-transplant leukemia/lymphoma remission. Thereby, not only more effective prevention and early diagnosis of transplant-related complications, but also prompt diagnosis of imminent post-transplant leukemia/lymphoma relapse became possible. This, in turn, enables a preemptive treatment and precise evaluation of the response to the treatment. Finally, the long-term results of allo-HSCT for hematological malignancies systematically improve.

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Authors and Affiliations

  1. Department of Pediatric Oncology, Hematology and Transplantology, Poznań University of Medical Sciences, Szpitalna 27/33, 60-572, Poznań, Poland

    Jacek Wachowiak

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  1. Jacek Wachowiak
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Correspondence to Jacek Wachowiak .

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  1. International Institute of Molecular and, Trojdena 4, Warszawa, 02-109, Poland

    Michal Witt

  2. , Institute of Human Genetics, Polish Academy of Sciences, ul. Strzeszynska 32, Poznan, 60479, Poland

    Malgorzata Dawidowska

  3. , Department of Pediatric Hematology, Silesian Academy of Medicine, 3 Maja 13-15, Zabrze, 41800, Poland

    Tomasz Szczepanski

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Wachowiak, J. (2012). Allogeneic Transplantation of Hematopoietic Stem Cells. In: Witt, M., Dawidowska, M., Szczepanski, T. (eds) Molecular Aspects of Hematologic Malignancies. Principles and Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29467-9_13

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