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Gene Expression Profiling in Hematologic Malignancies

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Molecular Aspects of Hematologic Malignancies

Part of the book series: Principles and Practice ((PRINCIPLES))

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Abstract

The vast majority of hematologic malignancies are clinically, prognostically, and genetically complex diseases. High-throughput gene expression studies, coupled with analysis of copy number alterations, directed sequencing, and functional assays provided the “bird’s eye view” on the tumor cell and its environment and greatly advanced the level of understanding of these tumors. In this chapter, we discuss the technical aspects of gene-expression profiling experiments, and review the results of major studies on lymphoid and myeloid leukemias and myelodysplastic syndromes that changed our understanding of these diseases. We also present translational and diagnostic implications of recent studies performed with the gene expression profiling platforms.

P. Juszczyński and B. Chapuy contributed equally

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Authors and Affiliations

  1. Institute of Hematology and Transfusion Medicine, Indiry Gandhi 14, 02-776, Warsaw, Poland

    Przemysław Juszczyński & Krzysztof Warzocha

  2. Harvard Medical School, Dana-Farber Cancer Institute, 450 Brookline Avenue Mayer 515, Boston, MA, 02215, USA

    Bjoern Chapuy

  3. Department of Molecular and Clinical Genetics, Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479, Poznań, Poland

    Małgorzata Szczepaniak

  4. International Institute of Molecular and Cell Biology, Trojdena 4, 02-109, Warsaw, Poland

    Małgorzata Szczepaniak

Authors
  1. Przemysław Juszczyński
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  2. Bjoern Chapuy
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  3. Małgorzata Szczepaniak
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  4. Krzysztof Warzocha
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Correspondence to Przemysław Juszczyński .

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Editors and Affiliations

  1. International Institute of Molecular and, Trojdena 4, Warszawa, 02-109, Poland

    Michal Witt

  2. , Institute of Human Genetics, Polish Academy of Sciences, ul. Strzeszynska 32, Poznan, 60479, Poland

    Malgorzata Dawidowska

  3. , Department of Pediatric Hematology, Silesian Academy of Medicine, 3 Maja 13-15, Zabrze, 41800, Poland

    Tomasz Szczepanski

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Juszczyński, P., Chapuy, B., Szczepaniak, M., Warzocha, K. (2012). Gene Expression Profiling in Hematologic Malignancies. In: Witt, M., Dawidowska, M., Szczepanski, T. (eds) Molecular Aspects of Hematologic Malignancies. Principles and Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29467-9_12

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