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Dielectric Detection Using Biochemical Assays

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Point-of-Care Diagnostics on a Chip

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Point-of-care (POC) diagnostics typically make use of labeling techniques that employ fluorescent, chemiluminescent, redox, or radioactive probes. Although such methods provide high sensitivity, they are complicated because their labeling steps require a significant amount of time and labor in their execution and in the analysis of their results. Thus, the portability, which is meant to be the primary advantage of POC systems, is sacrificed. The use of electronic devices for POC systems circumvents this problem, enabling label-free detection, miniaturization, and low costs. Label-free detection is made possible by direct electrical measurement of the sample molecules, which works by monitoring changes in their intrinsic electrical properties. Miniaturization and the integration of sensors and readout circuitry have been enabled by industrialized microfabrication technology. By integrating the sensors and circuitry onto a monolithic substrate, the fabrication cost can be remarkably reduced.

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Acknowledgements

This work was supported by the National Research and Development Program under grant NRDP, 2012-0001131 for the development of biomedical function monitoring biosensors and by the Center for Integrated Smart Sensor through the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology under Grant CISS-2011-0031845.

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Authors and Affiliations

  1. Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea

    Yang-Kyu Choi, Chang-Hoon Kim, Jae-Hyuk Ahn, Jee-Yeon Kim & Sungho Kim

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  1. Yang-Kyu Choi
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  2. Chang-Hoon Kim
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  3. Jae-Hyuk Ahn
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  4. Jee-Yeon Kim
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Correspondence to Yang-Kyu Choi .

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  1. , Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, 19104-6321, Pennsylvania, USA

    David Issadore

  2. , School of Engineering, Applied Sciences, Harvard University, Oxford Street 29, Cambridge, 02138, Massachusetts, USA

    Robert M. Westervelt

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Choi, YK., Kim, CH., Ahn, JH., Kim, JY., Kim, S. (2013). Dielectric Detection Using Biochemical Assays. In: Issadore, D., Westervelt, R. (eds) Point-of-Care Diagnostics on a Chip. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29268-2_5

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  • DOI: https://doi.org/10.1007/978-3-642-29268-2_5

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