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Nanomedicines for Nasal Drug Delivery

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Patenting Nanomedicines

Abstract

Human nose provides a myriad of therapeutic opportunities for treatment of local, systemic, as well as Central Nervous System (CNS) disorders due to its favorable anatomical and physiological features such as large surface area, high total blood flow, highly vascularized mucosa and a porous endothelial membrane. Drugs administered through nasal route enter directly into the systemic circulation and thus, bypass hepatic first-pass metabolism. Intranasal delivery of therapeutic agents also provides their direct entry into the CNS by bypassing the blood brain barrier (BBB) for treatment of conditions like Alzheimer’s disease, depression, migraine, schizophrenia etc. Amongst various approaches to deliver the therapeutic agents via nasal route, administration through nanocarriers has garnered burgeoning interest in recent years owing to their several appealing features like stability, in vivo protection against degradation and efflux back into the nasal cavity, as well as ability to control the release of the therapeutic agent. These nanocarriers can be therapeutically used as adjuvant in vaccines or as drug carriers. This chapter provides an insight into fundamentals of intranasal delivery with a focus on intellectual aspects of nanomedicines for nasal delivery.

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Authors and Affiliations

  1. Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, 281001, Uttar Pradesh, India

    Vikas Bali, Sumita Singh & Ajay Kumar

Authors
  1. Vikas Bali
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  2. Sumita Singh
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  3. Ajay Kumar
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Corresponding author

Correspondence to Vikas Bali .

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Editors and Affiliations

  1. , Faculty of Health Sciences, University Fernando Pessoa, Rua Carlos da Maia 296, Cacif, Porto, 4200-150, Portugal

    Eliana B. Souto

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© 2012 Springer-Verlag Berlin Heidelberg

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Bali, V., Singh, S., Kumar, A. (2012). Nanomedicines for Nasal Drug Delivery. In: Souto, E. (eds) Patenting Nanomedicines. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29265-1_8

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