Abstract
HBV (Hepatitis B Virus) infection is a severe global health problem. In recent years, the single point mutation as an essential element in the HBV evolution has been extensively studied, however, only the limited mutation loci were reported. In this paper, we proposed a new method to apply MORE (Mining Optimal Risk PattErn sets) and RPSW (Risk and Preventive Sets with Weights) algorithms to study the single point mutation loci in the HBV sequences. Experimental results show that the proposed approach is efficient to mine mutation loci, such as the reported mutation loci at positions ntT1753C, ntA1762T, ntG1764A, nt1896, and the new found mutation loci at positions ntA1436G, ntG1629A, ntA1383C, ntA1573T, and the risky of positive mutation loci at positions nt1726, nt1657, nt1463, nt1658, nt1498, nt1386. Furthermore, the proposed method is also able to find out highly relevant association rules or patterns based on the feature mutation loci.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
William, M., Lee, M.D.: Hepatitis B Virus Infection. New England Journal of Medicine 337(24), 1733–1745 (1997)
Goldstein, S.T., Zou, F., Hadler, S.C., Bell, B.P., Mast, E.E., Margolis, H.S.: A mathematical model to estimate global hepatitis B disease burden and vaccination impact. International Journal of Epidemiology 34, 1329–1339 (2005)
Zanetti, A.R., Van Damme, P., Shouval, D.: The global impact of vaccination against hepatitis B: A historical overview. Vaccine 26(49), 6266–6273 (2008)
Ganem, D.E., Schneider, R.J.: Hepadnaviridae: the viruses and their replication. In: Blaine Hollinger, F. (ed.) Viral Hepatitis (2001)
Norder, H., Couroucé, A.M., Coursaget, P., Echevarria, J.M., Lee, S.D., Mushahwar, I.K., Robertson, B.H., Locarnini, S., Magnius, L.O.: Genetic Diversity of Hepatitis B Virus Strains Derived Worldwide: Genotypes, Subgenotypes, and HBsAg Subtypes. Intervirology 47, 289–309 (2004)
Kramvis, A., Kem, M.C.: Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy. Journal of Viral Hepatitis 12(5), 456–464 (2005)
Luo, K.X.: Hepatitis B: Basic biology and clinical science, pp. 56–70. People’s Medical Publishing House (2001)
Ferrari, C.: Hepatitis B Virus Immunopathogenesis. Annual Review of Immunology 13(1), 29–60 (1995)
Abel, L., Dessein, A.J.: The impact of host genetics on susceptibility to human infectious diseases. Current Opinion in Immunology 9(4), 509–516 (1997)
Dean, M., Carrington, M., O’Brien, S.J.: Balanced polymorphism selected by genetic versus infectious human disease. Annual Review Genomics Hum. Genetics 3, 263–292 (2002)
Adrian, V., Hill, S.: The immunogenetics of human infectious diseases. Annual Review Immunology 16, 593–617 (1998)
Hill, A.V.: Host genetics of infectious diseases: old and new approaches converge. Emerging Infectious Disease 4(4), 695–697 (1998)
Takahashi, K., Aoyama, K., Ohno, N., Iwata, K., Akahane, Y., Baba, K., Yoshizawa, H., Mishiro, S.: The precore/core promoter mutant (T1762A1764) of hepatitis b virus: clinical significance and an easy method for detection. Reading, ROYAUME-UNI: Society for General Microbiology 76, 3159–3164 (1995)
Li, J., Fu, A.W.-C., Fahey, P.: Efficient discovery of risk patterns in medical data. Artificial Intelligence in Medicine 45, 77–89 (2009)
Zhang, J., He, J., Li, J., Ma, L.: Constraining and Summarizing Optimal Risk and Preventive Patterns in Medical Data. In: 4th International Conference on Bioinformatics and Biomedical Engineering, pp. 1–4. IEEE Press, Chengdu (2010)
Mitchell, T.M.: Machine learning. McGraw-Hill Science/Engineering/Math. (1997)
Hall, M., Frank, E., Holmes, G., Pfahringer, B., Reutemann, P., Witten, I.H.: The WEKA data mining software: an update. SIGKDD Explorations 11(1), 10–18 (2009)
Gange, S.J., Cole, S.R.: Epidemiologic Analysis - A Case-oriented Approach. Oxford University Press, New York (2002)
Jake Liang, T., Hasegawa, K., Rimon, N., Wands, J.R., Ben-Porath, E.: A Hepatitis B Virus Mutant Associated with an Epidemic of Fulminant Hepatitis. The New England Journal of Medicine 324(24), 1705–1709 (1991)
Okamoto, H., Tsuda, F., Akahane, Y., Sugai, Y., Yoshiba, M., Moriyama, K., Tanaka, T., Miyakawa, Y., Mayumi, M.: Hepatitis b virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. Journal of Virology 68(12), 8102–8110 (1994)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Zhang, Q. et al. (2012). A Study of the Single Point Mutation Loci in the Hepatitis B Virus Sequences via Optimal Risk and Preventive Sets with Weights. In: Sheng, Q.Z., Wang, G., Jensen, C.S., Xu, G. (eds) Web Technologies and Applications. APWeb 2012. Lecture Notes in Computer Science, vol 7235. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29253-8_39
Download citation
DOI: https://doi.org/10.1007/978-3-642-29253-8_39
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-29252-1
Online ISBN: 978-3-642-29253-8
eBook Packages: Computer ScienceComputer Science (R0)