Skip to main content
SpringerLink
Log in

Genes Involved in the Thermal Tolerance of Livestock

  • Chapter
  • First Online:
Environmental Stress and Amelioration in Livestock Production

Abstract

Although there is a good amount of knowledge about the physiological aspects, the effects of heat stress at the cellular and genetic level still remain unrevealed. Functional genomics research is providing new knowledge about the impact of heat stress on livestock production and reproduction. Using functional genomics to identify genes that are up- or down-regulated during a stressful event can lead to the identification of animals that are genetically superior for coping with stress and toward the creation of therapeutic drugs and treatments that target affected genes. Given the complexity of the traits related to adaptation to tropical environments, the discovery of genes controlling these traits is a very difficult task. With the development of molecular biotechnologies, new opportunities are available to characterize gene expression and identify key cellular responses to heat stress. These new tools will enable to improve the accuracy and the efficiency of selection for heat tolerance. Studies evaluating genes identified as participating in the cellular acclimation response from microarray analyses or genome-wide association studies have indicated that heat shock proteins are playing a major role in adaptation to thermal stress. Additional genes of interest which two or more studies have identified are the genes for fibroblast growth factor, solute carrier proteins, interluekins, and tick resistance genes. Genes which have only been identified by microarray analysis but not by genome-wide association studies include genes associated with cellular metabolism (phosphofructo kinase, isocitrate dehydrogenase, NADH dehydrogenase, glycosyltransferase, transcription factor, and mitochondrial inositol protein). Other genes of importance were thyroid hormone receptor, insulin-like growth factor II, and annexin.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adams MB, McMillen IC (2000) Actions of hypoxia on catecholamine synthetic enzyme mRNA expression before and after development of adrenal innervation in the sheep fetus. J Physiol 529(3):519–531

    PubMed  CAS  Google Scholar 

  • Ahmed A, Dunk C, Ahmad S, Khaliq A (2000) Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) and soluble Flt-1 by oxygen–a review. Placenta 21:S16–S24

    Google Scholar 

  • Alexander G, Williams D (1971) Heat stress and development of conceptus in domestic sheep. J Agri Sci 76:53–72

    Google Scholar 

  • Akerfelt MD, Trouillet V, Mezger  , Sistonen L (2007) Heat shock factors at a crossroad between stress and development. Ann N Y Acad Sci 1113:15–27

    PubMed  CAS  Google Scholar 

  • Amici C, Sistonene L, Gabriella Santoro M, Morimoto RI (1992) Antiproliferative prostaglandins activate heat shock transcription factor. Proc Natl Acad Sci 89:6227–6231

    PubMed  CAS  Google Scholar 

  • Ansari T, Fenlon S, Pasha S (2003) Morphometric assessment of the oxygen diffusive conductance in placentae from pregnancies complicated by intra-uterine growth restriction. Placenta 24:618–626

    PubMed  CAS  Google Scholar 

  • Battaglia FC, Meschia G (1978) Principal substrates of fetal metabolism. Physiol Rev 58(2):499–527

    PubMed  CAS  Google Scholar 

  • Barker DJ, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS (1993) Fetal nutrition and cardiovascular disease in adult life. Lancet 341:938–941

    PubMed  CAS  Google Scholar 

  • Bauman DE, Currie WB (1980) Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis. J Dairy Sci 63:1514–1529

    PubMed  CAS  Google Scholar 

  • Bell AW, Ehrhardt RA (2002) Regulation of placental nutrient transport and implications for fetal growth. Nutr Res Rev 15:211–230

    PubMed  CAS  Google Scholar 

  • Bell AW, McBride BW, Slepetis R, Early RJ, Currie WB (1989) Metabolites conceptus growth and maternal plasma hormones and chronic heat stress and prenatal development in sheep: I. J Anim Sci 67:3289–3299

    PubMed  CAS  Google Scholar 

  • Berman A (2004) Tissue and external insulation estimates and their effects on prediction of energy requirements and of heat stress. J Dairy Sci 87(5):1400–1412

    PubMed  CAS  Google Scholar 

  • Berman A (2005) Estimates of heat stress relief needs for Holstein dairy cows. J Anim Sci 83:1377–1384

    Google Scholar 

  • Blackshaw JK, Blackshaw AW (1994) Heat stress in cattle and the effect of shade on production and behavior: a review. Aust J Exp Agric 34:285–295

    Google Scholar 

  • Bligh J (1976) Introduction to acclimatory adaptation-including notes on terminology. In: Bligh J, Cloudsley-Thompson JL, Macdonald AG (eds) Environmental physiology of animals. Wiley, NY, pp 219–229

    Google Scholar 

  • Block J, Chase CC, Hansen PJ (2002) Inheritence of resistance of bovine preimplantation embryos to heat shock: relative importance of the maternal versus paternal contribution. Mol Reprod Dev 63:32–37

    PubMed  CAS  Google Scholar 

  • Bohmanova J, Misztal I, Tsuruta S, Norman HD, Lawlor TJ (2006) Short communication: genotype by environment interaction due to heat stress. J Dairy Sci 91:840–846

    Google Scholar 

  • Brouk MJ, Smith JF, Harner JP (2003) Effect of sprinkling frequency and airflow on respiration rate, body surface temperature and body temperature of heat stressed dairy cattle. In: Fifth international dairy housing proceedings. ASAE, Fort Worth, TX 29–31 Jan 2003, pp 263–268

    Google Scholar 

  • Buckley BA, Hofmann GE (2002) Thermal acclimation changes DNA-binding activity of heat shock factor 1 (HSF1) in the goby Gillichthys mirabilis: implications for plasticity in the heat-shock response in natural populations. J Exper Biol 205:3231–3240

    CAS  Google Scholar 

  • Carper SW, Duffy JJ, Gerner EW (1987) Perspectives in cancer: heat shock proteins in thermotolerance and other cellular processes. Cancer Res 47:5249–5255

    PubMed  CAS  Google Scholar 

  • Cerón-Muñoz M, Tonhati H, Costa CN, Rojas-Sarmiento D, Echeverri DM (2004) Factors that cause genotype by environment interaction and use of a multiple-trait herd-cluster model for milk yield of Holstein cattle from Brazil and Colombia. J Dairy Sci 87:2687–2692

    PubMed  Google Scholar 

  • Chan EKF, Nagaraj SH, Reverter A (2010) The evolution of tropical adaptation: comparing taurine and zebu cattle. Anim Genet 10:1365–2052

    Google Scholar 

  • Charmandari E, Tsigos C, Chrousos G (2005) Endocrinology of the stress response. Annu Rev Physiol 67:259–284

    PubMed  CAS  Google Scholar 

  • Christenson RK, Prior RL (1978) Uterine blood flow and nutrient uptake during late gestation in ewes with different number of fetuses. J Anim Sci 46:189–200

    PubMed  CAS  Google Scholar 

  • Cohen WR, Piasecki GJ, Cohn HE, Susa JB, Jackson BT (1991) Sympathoadrenal responses during hypoglycemia, hyperinsulinemia, and hypoxia in the ovine fetus. AJP Endo 261(1):95–102

    Google Scholar 

  • Collier RJ, Eley RM, Sharma AK, Pereira RM, Buffington DE (1981) Shade management in subtropical environment for milk yield and composition in Holstein and Jersey cows. J Dairy Sci 64:844–849

    Google Scholar 

  • Collier RJ, Doelger SG, Head HH, Thatcher WW, Wilcox CJ (1982) Effects of heat stress during pregnancy on maternal hormone concentrations, calf birth weight and postpartum milk yield of Holstein cows. J Anim Sci 54:309

    PubMed  CAS  Google Scholar 

  • Collier RJ, Baumgard LH, Lock AL, Bauman D (2005) Physiological limitations, nutrient partitioning. In: Sylvester-Bradley R, Wiseman J (eds) Yields of farmed species: constraints and opportunities in the 21st Century. pp 351–377

    Google Scholar 

  • Collier RJ, Dahl GE, VanBaale MJ (2006a) Major advances associated with environmental effects on dairy cattle. J Dairy Sci Centenial 89:1244–1253

    CAS  Google Scholar 

  • Collier RJ, Collier RP, Rhoads  , Baumgard LH (2008a) Invited review: genes involved in the bovine heat stress response. J Dairy Sci 91(2):445–454

    PubMed  CAS  Google Scholar 

  • Collier RJ, Miller MA, McLaughlin CL, Johnson HD, Baile CA (2008b) Effects of Recombinant Bovine Somatotropin (rbST) and season on plasma and milk insulin-like growth factors I (IGF-I) and II (IGF-II) in lactating dairy cows. Domest Anim Endocrinol 35:16–23

    PubMed  CAS  Google Scholar 

  • Collier RJ, Stiening CM, Pollard BC, VanBaale MJ, Baumgard LH, Gentry PC, Coussens PM (2006b) Use of gene expression microarrays for evaluating environmental stress tolerance at the cellular level in cattle. J Anim Sci 84:1–13

    Google Scholar 

  • Comline RS, Silver M (1966) Development of activity in the adrenal medulla of the foetus and new-born animal. British Med Bulletin 22(1):16–20

    CAS  Google Scholar 

  • Da Silva RG, La Scala Jr N, Tonhati H (2003) Radiative properties of the skin and hair coat of cattle and other animals. Trans ASAE 46(3):913–918

    Google Scholar 

  • De Vrijer B, Regnault TRH, Wilkening RB, Meshia G, Battaglia FC (2004) Placental uptake and transport of ACP, a neutral nonmetabolizable amino acid in an ovine model of fetal growth restriction. Am J Physiol Endocrinol Metab 287:1114–1124

    Google Scholar 

  • Drake AJ, Walker BR (2004) The intergenerational effects of fetal pro- gramming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk. J Endocrinol 180:1–16

    PubMed  CAS  Google Scholar 

  • Dutt RH (1963) Critical period for early embryo mortality in ewes exposed to high ambient temperatures. J Anim Sci 22:713

    Google Scholar 

  • Edwards JL, Ealy AD, Monterroso VH, Hansen PJ (1997) Ontogeny of temperature-regulated heat shock protein 70 synthesis in preimplantation bovine embryos. Mol Reprod Dev 48:25–33

    PubMed  CAS  Google Scholar 

  • Finch VA (1985) Comparison of non-evaporative heat transfer in different cattle breeds. Aust J Agric Res 36:497–508

    Google Scholar 

  • Fleshner M, Johnson JD (2005) Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function. Int J Hyperthermia 21:457–471

    PubMed  CAS  Google Scholar 

  • Fowden AL (1992) The role of insulin in fetal growth. Early Hum Dev 29(1–3):177–181

    PubMed  CAS  Google Scholar 

  • Fregley MJ (1996) Adaptations: some general characteristics. In: Fregley MJ, Blatteis CM (eds) Handbook of physiology, section 4: environmental physiology. Oxford University Press, Oxford, pp 3–15

    Google Scholar 

  • Galan HL, Hussey MJ, Barbera A, Ferrazzi E, Chung M, Hobbins JC, Battaglia FC (1999) Relationship of fetal growth to duration of heat stress in an ovine model of placental insufficiency. Amer J Ob Gyn 180:1278–1282

    CAS  Google Scholar 

  • Gaughan JB, Bonner S (2009) Hsp70 expression in cattle exposed to hot climatic conditions. In: Proceedings the 4th international congress on stress responses in biology and medicine, Sapporo Japan, PP 231

    Google Scholar 

  • Garrett AT, Goosens NG, Rehrer NG, Patterson MJ, Cotter JD (2009) Induction and decay of short-term heat acclimation. Eur J Appl Physiol 107:659

    PubMed  Google Scholar 

  • Gebremedhin KG, Porter WP, Cramer CO (1983) Quantitative analysis of the heat exchange through the fur layer of Holstein calves. Trans ASAE 26(1):188–193

    Google Scholar 

  • Gebremedhin KG, Porter WP, Warner RG (1984) Heat flow through pelage of calves—a sensitivity analysis. Trans ASAE 27(4):1140–1143

    Google Scholar 

  • Gebremedhin KG, Hillman PE, Lee CN, Collier RJ (2007) Sweating rate of dairy cows under shade and sunny environments. ASABE Paper No. 074083, presented at the 2007 ASABE 100th annual international meeting, Minneapolis Convection Center, Minneapolis, Minnesota, pp 17–20

    Google Scholar 

  • Gebremedhin KG, Hillman PE, Lee CN, Collier RJ, Willard ST, Arthington J, Brown-Brandl TM (2008) Sweating rates of dairy cows and beef heifers in hot conditions. Trans ASABE 51(6):2167–2178

    Google Scholar 

  • Gebremedhin KG, Lee CN, Hillman PE, Collier RJ (2010) Physiological responses of dairy cows during extended solar exposure. Trans ASABE 53(1):239–247

    Google Scholar 

  • Gebremedhin KG, Lee CN, Hillman PE, Brown-Brandl TM (2011) Body temperature and behavioral activities of four breeds of heifers in shade and full sun. App Eng J Agri ASABE 27(6): 999–1006

    Google Scholar 

  • Gluckman PD, Liggins GC (1984) Regulation of fetal growth. In: Beard RW, Nathanielsz PW (eds) Fetal Physiology and Medicine: the basis of perinatology, 2nd edn, vol VI. Butterworth, London, pp 511–557

    Google Scholar 

  • Grazul-Bilska AT, Borowicz PP, Johnson ML, Minten MA, Bilski JJ, Wroblewski R, Redmer DA, Reynolds LP (2010) Placental development during early pregnancy in sheep: vascular growth and expression of angiogenic factors in maternal placenta. Reproduction 140(1):165–174

    PubMed  CAS  Google Scholar 

  • Grazul-Bilska AT, Johnson ML, Borowicz PP, Minten M, Bilski JJ, Wroblewski R, Velimirovich M, Coupe LR, Redmer DA, Reynolds LP (2011) Placental development during early pregnancy in sheep: cell proliferation, global methylation, and angiogenesis in the fetal placenta. Reproduction 141:529–540

    PubMed  CAS  Google Scholar 

  • Green AS, Rozance PJ, Limesand SW (2010) Consequences of a compromised intrauterine environment on islet function. J Endocrinol 205(3):211–224

    PubMed  CAS  Google Scholar 

  • Green AS, Macko AR, Rozance PJ, Yates DT, Chen X, Hay WW Jr, Limesand SW (2011) Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus. Am J Physiol Endocrinol Metab 300(5):817–823

    Google Scholar 

  • Guzhova IK, Kislyakova O, Moskaliova I, Fridlanskaya M, Tytell M, Cheetham B (2001) In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance. Brain Res 914:66–73

    PubMed  CAS  Google Scholar 

  • Habib KE, Gold PW, Chrousos GP (2001) Neuroendocrinology of stress. Endocrinol Metab Clin North Am 30:695–728

    PubMed  CAS  Google Scholar 

  • Hafez SA (1964) Effects of high temperature on reproduction. Int J Biometeor 7:223

    Google Scholar 

  • Hafez SA, Borowicz P, Reynolds LP, Redmer DA (2010) Maternal and fetal microvasculature in sheep placenta at several stages of gestation. J Anatomy 216:292–300. doi:10.1111/j.1469-7580.2009.01184.x

    Google Scholar 

  • Hales JR, Fawcett AA, Bennett JW, Needham AD (1978) Thermal control of blood flow through capillaries and arteriovenous anastomoses in skin of sheep. Pflugers Arch 378:55–63

    PubMed  CAS  Google Scholar 

  • Hahn GL (1999) Dynamic responses of cattle to thermal heat loads. J Anim Sci 77(2):10–20

    PubMed  CAS  Google Scholar 

  • Hansen PJ (2004) Physiological and cellular adaptations of zebu cattle to thermal stress. Anim Reprod Sci 82–83:349–360

    PubMed  Google Scholar 

  • Hay WW (2006) Placental-fetal glucose exchange and fetal glucose metabolism. Trans Am Clin Climatol Assoc 117:321–339

    PubMed  Google Scholar 

  • Hayes B, Bowman P, Chamberlain A, Goddard M (2009) A validated genome-wide association study to breed cattle adapted to an environment altered by climate change. PLoS ONE 4:6676

    Google Scholar 

  • Hillman PE, Gebremedhin KG, Parkhurst AM, Fuquay J, Willard ST (2001) Evaporative and convective cooling of cows in a hot and humid environment. In livestock environment VI: Proceedings of the 6th International Symposium, ASABE, St. Joseph, MI, pp 343–350

    Google Scholar 

  • Hillman PE, Lee CN, Willard ST (2005) Thermoregulatory responses associated with lying and standing in heat-stressed dairy cows. Trans ASAE 48(2):795–801

    Google Scholar 

  • Horowitz M (2002) From molecular and cellular to integrative heat defense during exposure to chronic heat. Comp Biochem Physiol A Mol Integr Physiol 131(3):475–483

    PubMed  Google Scholar 

  • Horowitz M (2007) Heat acclimation and cross-tolerance against novel stressors: genomic-physiological linkage. Prog Brain Res 162:373–392

    PubMed  CAS  Google Scholar 

  • Horowitz M, Assadi H (2010) Heat acclimation-mediated cross-tolerance in cardioprotection: Do HSP70 and HIF-1a play a role? Ann N Y Acad Sci 1188:199–206

    PubMed  CAS  Google Scholar 

  • Horowitz M, Eli-Berchoer L, Wapinski I, Friedman N, Kodesh E (2004) Stress-related genomic responses during the course of heat acclimation and its association with ischemic-reperfusion cross-tolerance. J Appl Physiol 97:1496–1507

    PubMed  CAS  Google Scholar 

  • Horowitz M, Robinson SD (2007) Heat shock proteins and the heat shock response during hyperthermia and its modulation by altered physiological conditions. Prog Brain Res 162:433–436

    PubMed  CAS  Google Scholar 

  • Ianaro A, Ialenti A, Maffia P, Di Meglio P, Di Rosa M, Santoro MG (2003) Anti-Inflammatory Activity of 15-Deoxy-D12,14-PGJ2 and 2-Cyclopenten-1-one: Role of the Heat Shock Response. Mol Pharmacol 64:85–93

    PubMed  CAS  Google Scholar 

  • Ireland HE, Leoni F, Altaie O, Birch CS, Coleman RS, Hunter-Lavin C, Williams JJH (2007) Measuring the secretion of heat shock proteins from cells. Methods 43(176):183

    Google Scholar 

  • Jansson T, Scholtbach V, Powell TL (1998) Placental transport of leucine and lysine is reduced in intrauterine growth restriction. Pediatr Res 44:532–537

    PubMed  CAS  Google Scholar 

  • Johnson HD, Vanjonack WJ (1976) Effects of environmental and other stressors on blood hormone patterns in lactating animals. J Dairy Sci 59:1603–1617

    PubMed  CAS  Google Scholar 

  • Jousan FD, Hansen PJ (2004) Insulin-like growth factor-I as a survival factor for the bovine preimplantation embryo exposed to heat shock. Biol Reprod 71(5):1665–1670

    PubMed  CAS  Google Scholar 

  • Kamwanja LA, Chase CC, Gutierrez JA, Guerriero V, Olson TA, Hammond AC (1994) Responses of bovine lymphocytes to heat shock as modified by breed and antioxidant status. J Anim Sci 72:438–444

    PubMed  CAS  Google Scholar 

  • Kimmel E, Arkin H, Broday D, Berman A (1991) A model of evaporative cooling in a wetted hide. J Agric Eng Res 49(3):227–241

    Google Scholar 

  • Kingdom JCP, Kaufmann P (1997) Oxygen and placental villous development: origins of fetal hypoxia. Placenta 18:613–621

    PubMed  CAS  Google Scholar 

  • Kowalski GJ, Mitchell JW (1979) An analytical and experimental investigation of the heat transfer mechanism within fibrous media, ASME, New York, 79-WA/HT-40

    Google Scholar 

  • Kregel KC (2002) Molecular biology of thermoregulation invited review: heat schock proteins: modifying factors in physiological stress responses and acquired thermotolerance. J Appl Physiol 92:2177–2186

    PubMed  CAS  Google Scholar 

  • Kristensen TN, Løvendahl P, Berg P, Loeschcke V (2004) Hsp 72 is present in plasma from Holstein-Friesian dairy cattle, and the concentration level is repeatable across days and age classes. Cell Stress Chaperones 9:143–149

    PubMed  CAS  Google Scholar 

  • Leiser R, Krebs C, Klisch K, Ebert B, Dantzer V, Schuler G, Hoffmann B (1997) Villosity and microvasculature of the bovine placentome in the second half of gestation. J Anat 191:517–527

    PubMed  Google Scholar 

  • Leos RA, Anderson MJ, Chen X, Pugmire J, Anderson KA, Limesand SW (2010) Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction. American J Physiol 298(4):770–778

    Google Scholar 

  • Lillehammer M, Hayes BJ, Meuwissen THE, Goddard ME (2009) Gene by environment interactions for production traits in Australian dairy cattle. J Dairy Sci 92:2008–4017

    Google Scholar 

  • Limesand SW, Regnault TRH, Hay WW (2004) Characterization of glucose transporter 8 (GLUT8) in the ovine placenta of normal and growth restricted fetuses. Placenta 25(1):70–77

    PubMed  CAS  Google Scholar 

  • Limesand SW, Jensen J, Hutton JC, Hay WW (2005) Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction. Am J Physiol Regul Integr Comp Phyiol 288:1297–1305

    Google Scholar 

  • Limesand SW, Rozance PJ, Zerbe GO, Hutton JC, Hay WW (2006) Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction. Endocrinology 147:1488–1497

    PubMed  CAS  Google Scholar 

  • Limesand SW, Rozance PJ, Smith D, Hay WW Jr (2007) Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction. Am J Physiol Endocrinol Metab 293:1716–1725

    Google Scholar 

  • Maia ASC, daSilva RG, Loureiro CMB (2005) Sensible and latent heat loss from the body surface of Holstein cows in a tropical environment. Intl J Biometeor 50(1):17–22

    CAS  Google Scholar 

  • Maia ASC, daSilva RG, Loureiro CMB (2008) Latent heat loss of Holstein cows in a tropical environment: a prediction model. R Bras Zootec 37(10):1806–9290

    Google Scholar 

  • Manalu W, Johnson HD, Li R, Becker BA, Collier RJ (1991) Assessment of thermal status of somatotropin-injected lactating Holstein cows maintained under controlled-laboratory thermoneutral, hot and cold environments. J Nutr 121:2006–2019

    PubMed  CAS  Google Scholar 

  • McArthur AJ (1987) Thermal interaction between animal and microclimate–a comprehensive model. J Theor Biol 126(2):203–238

    PubMed  CAS  Google Scholar 

  • McDowell RE (1958) Physiological approaches to animal climatology. J Hered 49:52–61

    Google Scholar 

  • Moen AN (1973) Wildlife ecology- an analytical approach. Freeman and Company WH, San Francisco, p 458

    Google Scholar 

  • Magee DA, Meghen C, Harrison S, Troy CS, Cymbron T, Gaillard C, Morrow A, Maillard CG, Bradley DG (2002) A partial African ancestry for the creole cattle populations of the Caribbean. J Hered 93:429–432

    PubMed  CAS  Google Scholar 

  • Maloyan A, Palmon A, Horowitz M (1999) Heat acclimation increases basal HSP72 level and alters its produciton dynamics during heat stress. Am J Physiol Regul Integr Comp Physiol 276:1506–1515

    Google Scholar 

  • Maloyan A, Eli-Berchoer L, Semenza GL, Gerstenblith G, Stern GD, Horowitz M (2005) HIF-1a- targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heat. Physiol Genomics 23:79–88

    PubMed  CAS  Google Scholar 

  • Mossman HW (1987) Vertebrate fetal membranes. Rutgers University Press, New Brunswick

    Google Scholar 

  • Myers SA, Sparks JW, Makowski EL, Meschia G, Battaglia FC (1982) Relationship between placental blood flow and placental and fetal size in guinea-pig. Am J Physiol 24:404–409

    Google Scholar 

  • Norberg S, Powell TL, Jansson T (1998) Intrauterine growth restriction is associated with a reduced activity of placental taurine transporters. Pediatr Res 44:233–238

    PubMed  CAS  Google Scholar 

  • Olson AL, Pessin JE (1996) Structure, function, and regulation of the mammalian facilitative glucose transporter gene family. Annu Rev Nutr 16:235–256

    PubMed  CAS  Google Scholar 

  • Olson TA, Chase CC, Lucena C, Godoy E, Zuniga A, Collier RJ (2006) Effect of hair characteristics on the adaptation of cattle to warm climates. 8th World congress on genetics applied to livestock production, Belo Horizonte, MG, Brasil, 13–18 Aug 2006

    Google Scholar 

  • Owens JA (1991) Endocrine and substrate control of fetal growth: placental and maternal influences and insulin-like growth factors. Reprod Fertil Dev 3(5):501–517

    PubMed  CAS  Google Scholar 

  • Paula-Lopes FF, Chase CC, Al-Katanani YM, Krininger CE, Rivera RM, Tekin S, Majewski AC, Ocon OM, Olson TA, Hansen PJ (2003) Genetic divergence in cellular resisitance to heat shock in cattle: differences between breeds developed in temperate versus hot climates in responses of preimplantation embryos, reproductive tract tissues and lymphocytes to increased culture temperatures. Reprod 125:285–294

    CAS  Google Scholar 

  • Power GG (1989) Biology of temperature: the mammalian fetus. J Dev Physiol 12:295–304

    PubMed  CAS  Google Scholar 

  • Ravagnolo O, Misztal I, Hoogenboom G (2000) Genetic component of heat stress in dairy cattle, development of heat index function. J Dairy Sci 83:2120–2125

    PubMed  CAS  Google Scholar 

  • Regnault TRH, Friedman JE, Wilkening RB, Anthony RV, Hay WW (2005) Fetoplacental transport and utilization of amino acids in IUGR—a review. Placenta, pp 52–62

    Google Scholar 

  • Regnault TRH, Orbus RJ, De Vrijer B, Davidsen ML, Galan HL, Wilkening RB, Anthony RV (2002) Placental expression of VEGF, PlGF and their receptors in a model of placental insufficiency–intrauterine growth restriction (PI-IUGR). Placenta 23(2–3):132–144

    PubMed  CAS  Google Scholar 

  • Regnault TRH, de Vrijer B, Galan HL, Davidsen ML, Trembler KA, Battaglia FC, Wilkening RB, Anthony RV (2003) The relationship between transplacental O2 diffusion and placental expression of PlGF, VEGF and their receptors in a placental insufficiency model of fetal growth restriction. J Physiol 550:641–656. doi:10.1113/jphysiol.2003.039511

    PubMed  CAS  Google Scholar 

  • Regnault TRH, de Vrijer B, Galan HL, Wilkening RB, Battaglia FC, Meschia G (2007) Development and mechanisms of fetal hypoxia in severe fetal growth restriction. Placenta 28:714–723

    PubMed  CAS  Google Scholar 

  • Reynolds LP, Borowicz PP, Vonnahme KA (2005) Placental angiogenesis in sheep models of compromised pregnancy. J Physiol 565:43–58

    PubMed  CAS  Google Scholar 

  • Rhoads ML, Rhoads RP, VanBaale MJ, Collier RJ, Sanders SRS, Weber WJ, Crooker BA, Baumgard LH (2009) Effects of heat stress and plane of nutrition on lactating Holstein cows: I. Production, metabolism, and aspects of circulating somatotropin. J Dairy Sci 92:1986–1997

    PubMed  CAS  Google Scholar 

  • Roberts MF, Wenger CB, Stolwijk JAJ, Nadel ER (1977) Skin blood flow and sweating changes following exercise training and heat acclimatization. J Appl Physiol 43:133–137

    Google Scholar 

  • Ross JC, Fennessey PV, Wilkening RB, Battaglia FC, Meschia G (1996) Placental transport and fetal utilization of leucine in a model of fetal growth retardation. Am J Physiol Endocrinol Metab 270:491–503

    Google Scholar 

  • Sadiq HF, Das UG, Tracy TF, Devaskar SU (1999) Intra-uterine growth restriction differentially regulates perinatal brain and skeletal muscle glucose transporters. Brain Res 823(1–2):96–103

    PubMed  CAS  Google Scholar 

  • Sarge KD, Murphy SP, Morimoto RI (1993) Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Mol Cell Biol 13:1392–1407

    PubMed  CAS  Google Scholar 

  • Scott GH (1981) What is animal stress and how is it measured? J Anim Sci 52:150

    Google Scholar 

  • Shamovsky I, Nudler E (2008) New insights into the mechanism of heat shock response activation. Cell Mol Life Sci 65:855–861

    PubMed  CAS  Google Scholar 

  • Silanikove N, Shapiro F, Shinder D (2009) Acute heat stress brings down milk secretion in dairy cows by up-regulating the activity of the milk-borne negative feedback regulatory system. BMC Physiol 9(13): 

    Google Scholar 

  • Sonna LA, Fujita J, Gaffin SL, Lilly CM (2002) Molecular biology of thermoregulation invited review: effects of heat and cold stress on mammalian gene expression. J Appl Physiol 92:1725–1742

    PubMed  CAS  Google Scholar 

  • Stowell RR (2000) Heat stress relief and supplemental cooling. In: Dairy housing and equipment systems conference proceedings of the Natural Resource, Agriculture, and Engineering Service (NRAES). Cornell University, Ithaca, New York, Department of Agricultural and Biological Engineering, pp 129

    Google Scholar 

  • Straus DS, Glass CK (2001) Cyclopentenone prostaglandins: new insights on biological activities and cellular. Med Res Rev 21:185–210

    PubMed  CAS  Google Scholar 

  • Thorn SR, Regnault TRH, Brown LD, Rozance PJ, Keng J, Roper M, Wilkening RB, Hay WW, Friedman JE (2009) Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle. Endocrinol 150(7):3021–3030

    CAS  Google Scholar 

  • Thureen PJ, Trembler KA, Meschia G, Makowski EL, Wilkening RB (1992) Placental glucose transport in heat-induced fetal growth retardation. Am J Physiol Regul Integr Comp Physiol 263:578–585

    Google Scholar 

  • Tytell M (2005) Release of heat shock proteins (Hsps) and the effects of extracellular Hsps on neural cells and tissues. Int J Hyperthermia 21:445–455

    PubMed  CAS  Google Scholar 

  • Voellmy R, Boellmann F (2007) Chaperone regulation of the heat shock protein response. Adv Exp Med Biol 594:89–99

    PubMed  Google Scholar 

  • Xu Q, Ganju L, Fawcett TW, Holbrook NJ (1996) Vasopressin-induced heat shock protein expression in renal tubular cells. Lab Invest 74:178–187

    PubMed  CAS  Google Scholar 

  • Yates DT, Green AS, Limesand SW (2011) Catecholamines mediate multiple fetal adaptations during placental insufficiency that contribute to intrauterine growth restriction: lessons from hyperthermic sheep. J Pregnancy 11:740408

    Google Scholar 

  • Yousef MK (1984) Stress physiology in livestock, Vol I, basic principles. CRC Press Inc, Boca Raton, p 217

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Animal Sciences, University of Arizona, Tucson, AZ, 85721, USA

    Robert J. Collier

  2. Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, 48824, USA

    Kifle Gebremedhin

  3. Department of Physiological Sciences, University of Arizona, Tucson, AZ, 85721, USA

    Antoni R. Macko

  4. National Institute of Animal Nutrition and Physiology, Adugodi, Bangalore, Karnataka, 560 030, India

    Kajal Sankar Roy

Authors
  1. Robert J. Collier
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kifle Gebremedhin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Antoni R. Macko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kajal Sankar Roy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Robert J. Collier .

Editor information

Editors and Affiliations

  1. , Division of Physiology and Biochemistry, Central Sheep and Wool Research Institut, Avikanagar, Via-Jaipur, 304501, Rajasthan, India

    Veerasamy Sejian

  2. , Division of Physiology and Biochemistry, Central Sheep and Wool Research Institut, Avikanagar, Via-Jaipur, 304501, India

    S.M.K. Naqvi

  3. and OARDC, Department of Animal Sciences, The Ohio State University, Wooster, 44691, Ohio, USA

    Thaddeus Ezeji

  4. , Department of Veterinary Clinical Scienc, The Ohio State University, Columbus, 43210, Ohio, USA

    Jeffrey Lakritz

  5. , Carbon Management and Sequestration Cent, The Ohio State University, Columbus, 43210, Ohio, USA

    Rattan Lal

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Collier, R.J., Gebremedhin, K., Macko, A.R., Roy, K.S. (2012). Genes Involved in the Thermal Tolerance of Livestock. In: Sejian, V., Naqvi, S., Ezeji, T., Lakritz, J., Lal, R. (eds) Environmental Stress and Amelioration in Livestock Production. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29205-7_14

Download citation

Publish with us

Policies and ethics

Search

Navigation