Abstract
The brain is one of the most common sites of cancer metastasis, and radiation, in conjunction with surgery and steroid therapy, is a cornerstone of management of brain metastases. Whole brain radiation therapy (WBRT) using conventional external beam radiation is most commonly employed. Stereotactic radiosurgery (SRS) can be used in the adjuvant or upfront settings for patients with limited number of intracranial metastatic foci, sufficient extracranial disease control, and appropriate performance status.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Andrews DW et al (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363(9422):1665–1672
Chang EL et al (2009) Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 10(11):1037–1044
Aoyama H et al (2006) Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA 295(21):2483–2491
Patchell RA et al (1998) Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA 280(17):1485–1489
Patchell RA et al (1990) A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 322(8):494–500
Kocher M et al (2011) Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952–26001 study. J Clin Oncol 29(2):134–141
Sperduto PW et al (2010) Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients. Int J Radiat Oncol Biol Phys 77(3):655–661
Gaspar L et al (1997) Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 37(4):745–751
Gaspar LE et al (2010) The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 96(1):17–32
Kalkanis SN et al (2010) The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 96(1):33–43
Linskey ME et al (2010) The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 96(1):45–68
Lo SS et al (2012) Advances in radiation therapy of brain metastasis. Prog Neurol Surg 25:96–109
Tsao MN et al. (2012) Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): an American Society for Radiation Oncology evidence-based guideline. Pract Radiat Oncol 2:210 – 225. https://www.astro.org/Clinical-Practice/Guidelines/Brain-metastases.aspx
Shaw E et al (2000) Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90–05. Int J Radiat Oncol Biol Phys 47(2):291–298
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Weksberg, D.C., Lu, J.J., Chang, E.L. (2013). Palliative Radiation for Brain Metastases. In: Lee, N., Lu, J. (eds) Target Volume Delineation and Field Setup. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28860-9_27
Download citation
DOI: https://doi.org/10.1007/978-3-642-28860-9_27
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-28859-3
Online ISBN: 978-3-642-28860-9
eBook Packages: MedicineMedicine (R0)