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6th International Conference on Practical Applications of Computational Biology & Bioinformatics pp 157–164Cite as

Ectopic Foci Study on the Crest Terminalis in 3D Computer Model of Human Atrial

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Part of the book series: Advances in Intelligent and Soft Computing ((AINSC,volume 154))

Abstract

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Epidemiological studies show that AF tends to persist over time, creating electrophysiological and anatomical changes called remodeled atrial. It has been shown that these changes result in variations in conduction velocity (CV) in the atrial tissue. The changes caused by electrical remodeling in a model of action potential (AP) of atrial myocytes have been incorpotated in this study, coupled with an anatomically realistic three-dimensional model of human dilated atrium. Simulations of the spread of AP in terms of anatomical and electrical remodeling and remodeling of gap junctions were measured vulnerable windows of reentry generation on the crest terminalis of the atrium. The results obtained indicate that vulnerable window in the remodeling of gap junctions shifted 38 ms with respect to the model dilated, which shows the impact of structural remodeling Several types of permanent reentry of figures in form of eight and in form of rotor, favored by the underlying anatomy of the atrium were obtained.

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Authors and Affiliations

  1. Center for Research and Innovation in Engineering, University of Caldas, Street 65 # 26-10, Manizales, Colombia

    Carlos A. Ruiz-Villa & Andrés P. Castaño

  2. Language, Informatics Systems and Software Engineer Department, Pontifical University of Salamanca, Campus Madrid, Paseo Juan XXIII, 3, Madrid, Spain

    Andrés Castillo

  3. Engineering Faculty, University of Lomas of Zamora, Ruta Provincial 4, Km 2, Buenos Aires, Argentina

    Elvio Heidenreich

  4. Informatic and Computation Department, National University of Colombia, Campus La Nubia, Manizales, Colombia

    Carlos A. Ruiz-Villa

Authors
  1. Carlos A. Ruiz-Villa
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  2. Andrés P. Castaño
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  3. Andrés Castillo
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  4. Elvio Heidenreich
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Corresponding author

Correspondence to Carlos A. Ruiz-Villa .

Editor information

Editors and Affiliations

  1. , Dep. Informática / CCTC, Universidade do Minho, Largo do Paco, Braga, 4710 - 057, Portugal

    Miguel P. Rocha

  2. European Bioinformatics Institute, Wellcome Trust Genome Campus, EMBL Outstation - Hinxton, Hinxton, CB10 1SD, United Kingdom

    Nicholas Luscombe

  3. , Department of Informatics, University of Vigo, Edificio Politécnico. Campus Universitario As Lagoas s/n, Ourense, 32004, Spain

    Florentino Fdez-Riverola

  4. Faculty of Science, Department of Computing Science, University of Salamanca, Plaza de la Merced S/N, Salamanca, 37008, Spain

    Juan M. Corchado Rodríguez

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© 2012 Springer-Verlag Berlin Heidelberg

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Ruiz-Villa, C.A., Castaño, A.P., Castillo, A., Heidenreich, E. (2012). Ectopic Foci Study on the Crest Terminalis in 3D Computer Model of Human Atrial. In: Rocha, M., Luscombe, N., Fdez-Riverola, F., Rodríguez, J. (eds) 6th International Conference on Practical Applications of Computational Biology & Bioinformatics. Advances in Intelligent and Soft Computing, vol 154. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28839-5_18

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  • DOI: https://doi.org/10.1007/978-3-642-28839-5_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-28838-8

  • Online ISBN: 978-3-642-28839-5

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