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mRNA Turnover in Trypanosomes

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RNA Metabolism in Trypanosomes

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 28))

Abstract

Most kinetoplastid mRNAs are synthesised by RNA polymerase II, then trans spliced, polyadenylated, and exported from the nucleus. The polycistronic nature of kinetoplastid transcription, however, means that—with a few exceptions—the amount of mRNA is determined by post-transcriptionally. Once in the cytoplasm, the amount of mRNA is determined by the rate of mRNA degradation and the amount of protein by the rates of translation initiation, elongation, and protein turnover. In many cases, regulation of mRNA turnover has been found to play a dominant role. This review discusses the mechanisms of mRNA degradation in kinetoplastids, and how that degradation is controlled.

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Acknowledgements

Work in my laboratory is supported by the Land of Baden-Württemberg and the Deutsche Forschungsgemeinschaft.

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  1. Zentrum für Molekulare Biologie ZMBH, Im Neuenheimer Feld 282, 106249, 69120, Heidelberg, Germany

    Christine Clayton

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Correspondence to Christine Clayton .

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  1. , Department of Biology and Chemistry, Justus Liebig University of Giessen, Heinrich-Buff-Ring 58, Giessen, 35392, Germany

    Albrecht Bindereif

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Clayton, C. (2012). mRNA Turnover in Trypanosomes. In: Bindereif, A. (eds) RNA Metabolism in Trypanosomes. Nucleic Acids and Molecular Biology, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28687-2_4

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