Abstract
The chapter gives an overview on modern technologies utilizing optical waveguides for biological, medical and environmental sensing. Section 28.2 presents state-of-the-art transduction mechanisms used in extrinsic sensor schemes as well as the potential and setup of the corresponding biooptrodes. The emphasis of Sect. 28.3 is on intrinsic methods, where the optical waveguide works as a bio-optical transducer itself. High precision techniques to evaluate the resulting changes of the waveguide’s properties will be discussed as well as the impact of the waveguide’s geometry on functionality and sensitivity of the sensor. In order to illustrate the variety of possible implementations, two novel biosensors will be presented in detail. The first one deploys a planar-optical waveguide to form a microring resonator, while the second uses grating structures inscribed in an optical fiber for the excitation of surface plasmon waves. Section 28.4 gives an introduction to the necessary biofunctionalization of the optical waveguide surface. Section 28.5 discusses the assembly of the sensor with focus on coupling and alignment of the light source.
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References
Allsop, T., Reeves, R., Webb, D.J., Bennion, I., Neal, R.: A high sensitivity refractometer based upon a long period grating Mach-Zehnder interferometer. Rev. Sci. Instrum. 73, 1702 (2002)
Allsop, T., Zhang, L., Bennion, I.: Detection of organic aromatic compounds in paraffin by a long-period fiber grating optical sensor with optimized sensitivity. Opt. Commun. 191, 181–190 (2001)
Almeida, V.R., Panepucci, R.R., Lipson, M.: Nanotaper for compact mode conversion. Opt. Lett. 28, 1302–1304 (2003)
Armani, A.M., Kulkarni, R.P., Fraser, S.E., Flagan, R.C., Vahala, K.J.: Label-free, single-molecule detection with optical microcavities. Science 317, 783 (2007)
Armani, D.K., Kippenberg, T.J., Spillane, S.M., Vahala, K.J.: Ultra-high-Q toroid microcavity on a chip. Nature 421, 925–928 (2003)
Bishop, A.R., Nuzzo, R.G.: Self-assembled monolayers: Recent developments and applications. Curr. Opin. Colloid Interface Sci. 1(1), 127–136 (1996)
Blair, S., Chen, Y.: Resonant-enhanced evanescent-wave fluorescence biosensing with cylindrical optical cavities. Appl. Opt. 40, 570–582 (2001)
Bogaerts, W., Taillaert, D., Dumon, P., Van Thourhout, D., Baets, R., Pluk, E.: A polarization-diversity wavelength duplexer circuit in silicon-on-insulator photonic wires. Opt. Express 15, 1567–1578 (2007)
Boyd, R.W., Heebner, J.E.: Sensitive disk resonator photonic biosensor. resonance 5, 7 (2001)
Chao, C., Guo, L.J.: Polymer microring resonators fabricated by nanoimprint technique. J. Vac. Sci. Technol. B 20, 2862 (2002)
Chao, C.Y., Fung, W., Guo, L.J.: Polymer microring resonators for biochemical sensing applications. IEEE J. Sel. Top. Quant. Electr. 12, 134–142 (2006)
Chao, C.Y., Guo, L.J.: Biochemical sensors based on polymer microrings with sharp asymmetrical resonance. Appl. Phys. Lett. 83, 1527 (2003)
Chao, C.Y., Guo, L.J.: Reduction of surface scattering loss in polymer microrings using thermal-reflow technique. IEEE Photonics Technol. Lett. 16, 1498–1500 (2004)
Chao, C.Y., Guo, L.J.: Design and optimization of microring resonators in biochemical sensing applications. J. Lightwave Technol. 24, 1395 (2006)
Chen, R.T., Lin, L., Choi, C., Liu, Y.J., Bihari, B., Wu, L., Tang, S., Wickman, R., Picor, B., Hibbs-Brenner, M.K., et al.: Fully embedded board-level guided-wave optoelectronic interconnects. Proceedings-IEEE 88, 780–793 (2000)
Chiu, M.H., Shih, C.H., Chi, M.H.: Optimum sensitivity of single-mode D-type optical fiber sensor in the intensity measurement. Sens. Actuators, B 123, 1120–1124 (2007)
Chryssis, A.N., Saini, S.S., Lee, S.M., Yi, H., Bentley, W.E., Dagenais, M.: Detecting hybridization of DNA by highly sensitive evanescent field etched core fiber Bragg grating sensors. IEEE J. Sel. Top. Quantum Electron. 11, 864–872 (2005)
Dakin, J., Culshaw, B.: Optical Fiber Sensors, vol. 4. Artech House, Boston (1997)
Daniels, P.B., Deacon, J.K., Eddowes, M.J., Pedley, D.G.: Surface plasmon resonance applied to immunosensing. Sens. Actuators 15(1), 11–18 (1988)
Day, Y.S.N., Baird, C.L., Rich, R.L., Myszka, D.G.: Direct comparison of binding equilibrium, thermodynamic, and rate constants determined by surface-and solution-based biophysical methods. Protein Sci. 11(5), 1017–1025 (2002)
De Vos, K., Bartolozzi, I., Schacht, E., Bienstman, P., Baets, R.: Silicon-on-Insulator microring resonator for sensitive and label-free biosensing. Opt. Express 15, 7610–7615 (2007)
Dostalek, J., Ctyroky, J., Homola, J., Brynda, E., Skalsky, M., Nekvindova, P., Spirkova, J., Skvor, J., Schroefel, J.: Surface plasmon resonance biosensor based on integrated optical waveguide. Sens. Actuators, B 76, 8–12 (2001)
Drapp, B., Piehler, J., Brecht, A., Gauglitz, G., Luff, B.J., Wilkinson, J.S., Ingenhoff, J.: Integrated optical Mach-Zehnder interferometers as simazine immunoprobes. Sens. Actuators, B 39, 277–282 (1997)
Eggins, B.R.: Chemical Sensors and Biosensors. Wiley, London (2002)
Epstein, J.R., Leung, A.P.K., Lee, K.H., Walt, D.R.: High-density, microsphere-based fiber optic DNA microarrays. Biosens. Bioelectron. 18, 541–546 (2003)
Feldstein, M.J., Golden, J.P., Rowe, C.A., MacCraith, B.D., Ligler, F.S.: Array biosensor: optical and fluidics systems. Biomedical Microdevices 1, 139–153 (1999)
Fort, E., Gresillon, S.: Surface enhanced fluorescence. J. Phys. D: Appl. Phys. 41, 13001 (2008)
Gershon, P.D., Khilko, S.: Stable chelating linkage for reversible immobilization of oligohistidine tagged proteins in the BIAcore surface plasmon resonance detector. J. Immunol. Methods 183(1), 65–76 (1995)
Guo, L.J.: Nanoimprint lithography: methods and material requirements. Adv. Mater. 19, 495–513 (2007)
Hauffe, R., Siebel, U., Petermann, K., Moosburger, R., Kropp, J.R., Arndt, F.: Methods for passive fiber chip coupling of integrated optical devices. In: Electronic Components and Technology Conference, Las Vegas, USA, pp. 238–243. (2000)
He, Y.J., Lo, Y.L., Huang, J.F.: Optical-fiber surface-plasmon-resonance sensor employing long-period fiber gratings in multiplexing. J. Opt. Soc. Am. B: Opt. Phys. 23, 801–811 (2006)
Henzi, P., Rabus, D.G., Wallrabe, U., Mohr, J.: Fabrication of photonic integrated circuits by DUV-induced modification of polymers. In: Proceedings of the SPIE, vol. 5451, pp. 24–31 (2004)
Hoffman, W.L., O’Shannessy, D.J.: Site-specific immobilization of antibodies by their oligosaccharide moieties to new hydrazide derivatized solid supports. J. Immunol. Methods 112(1), 113–120 (1988)
Holm, J., Ahlfeldt, H., Svensson, M., Vieider, C.: Through-etched silicon carriers for passive alignment of optical fibers to surface-active optoelectronic components. Sens. Actuators, A 82, 245–248 (2000)
Homola, J., Dostalek, J.: Surface plasmon resonance based sensors. Springer Verlag, New York (2006)
Horie, K., Ushiki, H., Winnik, F.M.: Molecular Photonics—Fundamentals and Practical Aspects. Wiley-VCH, Weinheim (2000)
Iga, M., Seki, A., Watanabe, K.: Hetero-core structured fiber optic surface plasmon resonance sensor with silver film. Sens. Actuators, B 101, 368–372 (2004)
Jinn-Nan, L., et al.: Comparison of site-specific coupling chemistry for antibody immobilization on different solid supports. J. Chromatogr. A 542, 41–54 (1991)
Johnsson, B., Lofas, S., Lindquist, G.: Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors. Anal. Biochem. 198(2), 268–277 (1991)
Johnsson, B., Lofas, S., Lindquist, G., Edstrom, A., Hillgren, R.M.M., Hansson, A.: Comparison of methods for immobilization to carboxymethyl dextran sensor surfaces by analysis of the specific activity of monoclonal antibodies. Journal of Molecular Recognition 8(1–2), 125–131 (1995)
Kick, A., Bonsch, M., Kummer, K., Vyalikh, D.V., Molodtsov, S.L., Mertig, M.: Controlling structural properties of self-assembled oligonucleotide-mercaptohexanol monolayers. J. Electron Spectrosc. Relat. Phenom. 172(1–3), 36–41 (2009)
Kirchner, R., Landgraf, R., Bertram, M.: Fischer. Direct UV-nanoimprint of polymer microring resonators as optical transducers. GMM-Fachbericht-Mikro-Nano-Integration, W.J. (2010)
Kretschmann, E.: Die Bestimmung optischer Konstanten von Metallen durch Anregung von Oberflaechenplasmaschwingungen. Z. Phys. A: At. Nucl. 241, 313–324 (1971)
Krioukov, E., Greve, J., Otto, C.: Performance of integrated optical microcavities for refractive index and fluorescence sensing. Sens. Actuators, B 90, 58–67 (2003)
Kummer, K., Vyalikh, D.V., Gavrila, G., Kade, A., Weigel-Jech, M., Mertig, M., Molodtsov, S.L.: High-resolution photoelectron spectroscopy of self-assembled mercaptohexanol monolayers on gold surfaces. J. Electron Spectrosc. Relat. Phenom. 163(1–3), 59–64 (2008)
Lahiri, J., Isaacs, L., Tien, J., Whitesides, G.M.: A strategy for the generation of surfaces presenting ligands for studies of binding based on an active ester as a common reactive intermediate: a surface plasmon resonance study. Anal. Chem 71(4), 777–790 (1999)
Landgraf, R., Kaiser, M.K., Posseckardt, J., Adolphi, B., Fischer, W.J.: Functionalization of Polymer Sensor Surfaces by Oxygen Plasma Treatment. Procedia Chemistry 1, 1015–1018 (2009)
Little, B.E., Chu, S.T., Haus, H.A., Foresi, J., Laine, J.P.: Microring resonator channel dropping filters. J. Lightwave Technol. 15, 998–1005 (1997)
Little, B.E., Chu, S.T., Pan, W., Ripin, D., Kaneko, T., Kokubun, Y., Ippen, E.: Vertically coupled glass microring resonator channel droppingfilters. IEEE Photonics Technol. Lett. 11, 215–217 (1999)
Luff, B.J., Harris, R.D., Wilkinson, J.S., Wilson, R., Schiffrin, D.J.: Integrated-optical directional coupler biosensor. Opt. Lett. 21, 618–620 (1996)
Mann, C.J., Stephens, S.K., Burke, J.F.: Production of protein microarrays. In: Kambhampati, D. (ed.) Protein Microarray Technology, pp. 165–194. Wiley-VCH, Weinheim (2004)
Marcatili, E.A.J.: Bends in optical dielectric guides. Bell System Technical Journal 48, 2103–2132 (1969)
Mayinger, F., Feldmann, O.: Optical Measurements—Techniques and Apllications. Springer, New York (2001)
Mertig, M., Kick, A., Bonsch, M., Katzschner, B., Voigt, J., Sonntag, F., Schilling, N., Klotzbach, U., Danz, N., Begemann, S., et al.: A novel platform technology for the detection of genetic variations by surface plasmon resonance. In: IEEE Sensors 2009, pp. 392–395. (2010)
Millaruelo, M., Eng, L.M., Mertig, M., Pilch, B., Oertel, U., Opitz, J., Sieczkowska, B., Simon, F., Voit, B.: Photolabile carboxylic acid protected terpolymers for surface patterning. Part 2: Photocleavage and film patterning. Langmuir 22(22), 9446–9452 (2006)
Minh, P.N., Ono, T., Tanaka, S., Esashi, M.: Near-field optical apertured tip and modified structures for local field enhancement. Appl. Opt 40, 2479–2484 (2001)
Moerman, I., Van Daele, P.P., Demeester, P.M.: A review on fabrication technologies for the monolithic integration of tapers with III-V semiconductor devices. IEEE J. Sel. Topics in. Quantum Electron. 3, 1308–1320 (1998)
Monzon-Hernandez, D., Villatoro, J.: High-resolution refractive index sensing by means of a multiple-peak surface plasmon resonance optical fiber sensor. Sens. Actuators, B 115, 227–231 (2006)
Nemova, G., Kashyap, R.: Theoretical model of a planar integrated refractive index sensor based on surface plasmon-polariton excitation with a long period grating. J. Eur. Opt. Soc. Part B 24, 2696–2701 (2007)
Obando, L.A., Booksh, K.S.: Tuning dynamic range and sensitivity of white-light, multimode, fiber-optic surface plasmon resonance sensors. Anal. Chem. 71, 5116–5122 (1999)
Opitz, J., Braun, F., Seidel, R., Pompe, W., Voit, B., Mertig, M.: Site-specific binding and stretching of DNA molecules at UV-light-patterned aminoterpolymer films. Nanotechnology 15, 717 (2004)
Ostuni, E., Chapman, R.G., Holmlin, R.E., Takayama, S., Whitesides, G.: A survey of structure-property relationships of surfaces that resist the adsorption of protein. Langmuir 17(18), 5605–5620 (2001)
Othonos, A., Kalli, K.: Fiber Bragg Gratings. Artech House, Boston (1999)
Piliarik, M., Homola, J., Manikova, Z., Ctyroky, J.: Surface plasmon resonance sensor based on a single-mode polarization-maintaining optical fiber. Sens. Actuators, B 90, 236–242 (2003)
Poon, J., Zhu, L., DeRose, G., Yariv, A.: Polymer microring coupled-resonator optical waveguides. J. Lightwave Technol. 24, 1843 (2006)
Raether, H.: Surface Plasmons on Smooth and Rough Surfaces and on Gratings. Springer-Verlag Berlin (1988)
Roelkens, G., Van Thourhout, D., Baets, R., Noetzel, R., Smit, M.: Laser emission and photodetection in an InP/InGaAsP layer integrated on and coupled to a Silicon-on-Insulator waveguide circuit. Opt. Express 14, 8154–8159 (2006)
Schmitt, K., Schirmer, B., Hoffmann, C., Brandenburg, A., Meyrueis, P.: Interferometric biosensor based on planar optical waveguide sensor chips for label-free detection of surface bound bioreactions. Biosens. Bioelectron. 22, 2591–2597 (2007)
Schuster, T., Herschel, R., Neumann, N., Schaffer, C.G.: Miniaturized long-period fiber grating assisted surface plasmon resonance sensor. J. Lightwave Technol. 99, 1–1 (2011)
Seibel, E.J., Johnston, R.S., Melville, C.D.: A full-color scanning fiber endoscope. In: Proceedings of the SPIE 6083 Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI, pp. 9–16. (2006)
Slavik, R., Homola, J., Ctyroky, J.: Single-mode optical fiber surface plasmon resonance sensor. Sens. Actuators, B 54, 74–79 (1999)
Snyder, A.W., Love. J.D.:Optical Waveguide Theory. Chapman& Hall, London (1991)
Souriau, J.C., Cobbe, A., Delatouche, N., Massit, C.: Passive fibre alignment on optoelectronic components for electro-optical links based on single-chip technology and VCSELs. In: technical paper presented at Strasbourg during an IMPS European Meeting, vol. 2 (2001)
Spackova, B., Piliarik, M., Kvasnicka, P., Themistos, C., Rajarajan, M., Homola, J.: Novel concept of multi-channel fiber optic surface plasmon resonance sensor. Sens. Actuators, B 139, 199–203 (2009)
Spinke, J., Liley, M., Schmitt, F.J., Guder, H.J., Angermaier, L., Knoll, W.: Molecular recognition at self-assembled monolayers: Optimization of surface functionalization. J. Chem. Phys. 99, 7012 (1993)
Stadermann, J., Erber, M., Komber, H., Brandt, J., Eichhorn, K.J., Bonsch, M., Mertig, M., Voit, B.: Photopatternable films of block copolymers prepared through double-click reaction. Macromolecules 43(7), 3136–3140 (2010)
Stiles, P.L., Dieringer, J.A., Shah, N.C., Van Duyne, R.P.: Surface-enhanced Raman spectroscopy. Annu. Rev. Anal. Chem. 1, 601–626 (2008)
Sure, A., Dillon, T., Murakowski, J., Lin, C., Pustai, D., Prather, D.W.: Fabrication and characterization of three-dimensional silicon tapers. Communications 1, 6 (2002)
Taillaert, D., Bogaerts, W., Bienstman, P., Krauss, T.F., Van Daele, P., Moerman, I., Verstuyft, S., De Mesel, K., Baets, R.: An out-of-plane grating coupler for efficient butt-coupling between compact planar waveguides and single-mode fibers. IEEE J. Quantum. Electron. 38, 949–955 (2002)
Tamir, T., Peng, S.: Analysis and design of grating couplers. Appl. Phys. A 14, 235–254 (1977)
Ulman, A.: Formation and structure of self-assembled monolayers. Chem. Rev 96(4), 1533–1554 (1996)
Utzinger, U., Richards-Kortum, R.R.: Fiber optic probes for biomedical optical spectroscopy. Journal of Biomedical Optics 8, 121 (2003)
Van Laere, T., Claes, T., Schrauwen, J., Scheerlinck, S., Bogaerts, W., Taillaert, D., O Faolain, L., Van Thourhout, D., Baets, R.: Compact focusing grating couplers for silicon-on-insulator integrated circuits. IEEE Photonic. Tech. Lett. 19, 1919 (2007)
Vo-Dinh, T., Cullum, B.M., Stokes, D.L.: Nanosensors and biochips: frontiers in biomolecular diagnostics. Sens. Actuators, B 74, 2–11 (2001)
Vollmer, F., Braun, D., Libchaber, A., Khoshsima, M., Teraoka, I., Arnold, S.: Protein detection by optical shift of a resonant microcavity. Appl. Phys. Lett. 80, 4057 (2002)
Wahlbrink, T., Tsai, W.S., Waldow, M., Foerst, M., Bolten, J., Mollenhauer, T., Kurz, H.: Fabrication of high efficiency SOI taper structures. Microelectron. Eng. 86, 1117–1119 (2009)
Waldhaeusl, R., Schnabel, B., Dannberg, P., Kley, E.B., Braeuer, A., Karthe, W.: Efficient coupling into polymer waveguides by gratings. Appl. Opt. 36, 9383–9390 (1997)
Yalcin, A., Popat, K.C., Aldridge, J.C., Desai, T., Hryniewicz, J., Chbouki, N., Little, B.E., King, O., Van, V., Chu, S., et al.: Optical sensing of biomolecules using microring resonators. IEEE J. Sel. Top. Quantum Electron. 12 148–154 (2006)
Yang, N., Su, X., Tjong, V., Knoll, W.: Evaluation of two-and three-dimensional streptavidin binding platforms for surface plasmon resonance spectroscopy studies of DNA hybridization and protein-DNA binding. Biosens. Bioelectron. 22(11), 2700–2706 (2007)
Yariv, A.: Coupled-mode theory for guided-wave optics. IEEE J. Quantum. Electron. 9, 919–933 (1973)
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Schuster, T., Landgraf, R., Finn, A., Mertig, M. (2012). Biosensing with Optical Waveguides. In: Gerlach, G., Wolter, KJ. (eds) Bio and Nano Packaging Techniques for Electron Devices. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28522-6_28
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