Nevogenesis pp 111-115 | Cite as

Nevogenesis: A Benign Metastatic Process?: An Update

  • Andrew L. Ross
  • Margaret I. Sanchez
  • James M. GrichnikEmail author


Cutaneous nevogenesis is largely considered a localized event that occurs exclusively in the dermis and/or epidermis. However, the presence of circulating nevocytes suggests that other, more systemic, benign metastatic processes could also contribute to nevogenesis. The theoretical role of lymphatic and hematogenous dissemination of loosely adherent, immature nevus progenitor cells in the development of nodal nevi and eruptive melanocytic nevi will be reviewed.


BRAF V600E Mutation Melanocytic Nevus Hematogenous Dissemination Hematogenous Route Clonal Heterogeneity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of Interest

DigitalDerm, Inc – major shareholder. Spectral Image, Inc – past grants and consulting. MELA Sciences, Inc – past grants and consulting. Genentech – consultant. Archives of Dermatology, skINsight – section editor.


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Copyright information

© Springer- Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Andrew L. Ross
    • 1
  • Margaret I. Sanchez
    • 1
  • James M. Grichnik
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Dermatology and Cutaneous SurgeryUniversity of Miami Miller School of MedicineMiamiUSA
  2. 2.Melanoma Program, Department of Dermatology and Cutaneous SurgerySylvester Comprehensive Cancer CenterMiamiUSA
  3. 3.Interdisciplinary Stem Cell Institute, Miller School of MedicineUniversity of MiamiMiamiUSA

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