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Nevogenesis pp 69-72 | Cite as

Nevi in Children and Adults: Dermoscopic Patterns and the Development of New Nevi

  • Tracey Liebman
  • Natalia Jaimes Lopez
  • Stephen W. DuszaEmail author
Chapter
  • 456 Downloads

Abstract

Nevi are the strongest risk factor for melanoma, as the risk of melanoma rises in individuals with a high number of melanocytic nevi. Yet, the melanocytic nevi in an individual change throughout one’s lifetime. By definition, acquired nevi appear after birth; the number of acquired nevi increases in the early decades, followed by a decrease in later life. According to the prevailing wisdom, individuals acquire nevi which then senesce and ultimately disappear; however, the process of nevogenesis may, in fact, be more dynamic. Although dermoscopy can provide greater insights into nevogenesis, there are relatively few studies that closely follow the development of nevi over an individual’s lifetime. Cross-sectional and longitudinal studies regarding the dermoscopic pattern of nevi and the number of melanocytic nevi in both children and adults will be discussed below.

Keywords

Strong Risk Factor Melanocytic Nevus Predominant Pattern Dysplastic Nevus Benign Nevus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Gandini S, Sera F, Cattaruzza MS, Pasquini P, Abeni D, Boyle P, Melchi CF. Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi. Eur J Cancer. 2005;41(1):28–44.PubMedCrossRefGoogle Scholar
  2. 2.
    Holly EA, Kelly JW, Shpall SN, Chiu SH. Number of melanocytic nevi as a major risk factor for malignant melanoma. J Am Acad Dermatol. 1987;17(3):459–68.PubMedCrossRefGoogle Scholar
  3. 3.
    Cooke KR, Spears GF, Skegg DC. Frequency of moles in a defined population. J Epidemiol Community Health. 1985;39(1):48–52.PubMedCrossRefGoogle Scholar
  4. 4.
    MacKie RM, English J, Aitchison TC, Fitzsimons CP, Wilson P. The number and distribution of benign pigmented moles (melanocytic naevi) in a healthy British population. Br J Dermatol. 1985;113(2):167–74.PubMedCrossRefGoogle Scholar
  5. 5.
    Schafer T, Merkl J, Klemm E, Wichmann HE, Ring J. The epidemiology of nevi and signs of skin aging in the adult general population: results of the KORA-survey 2000. J Invest Dermatol. 2006;126(7):1490–6.PubMedCrossRefGoogle Scholar
  6. 6.
    Zalaudek I, Grinschgl S, Argenziano G, Marghoob AA, Blum A, Richtig E, et al. Age-related prevalence of dermoscopy patterns in acquired melanocytic naevi. Br J Dermatol. 2006;154(2):299–304.PubMedCrossRefGoogle Scholar
  7. 7.
    Scope A, Marghoob AA, Dusza SW, Satagopan JM, Agero AL, Benvenuto-Andrade C, et al. Dermoscopic patterns of naevi in fifth grade children of the Framingham school system. Br J Dermatol. 2008;158(5):1041–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Oztas P, Ilhan MN, Polat M, Alli N. Clinical and dermoscopic characteristics of melanocytic nevi in Turkish children and their relationship with environmental and constitutional factors. Dermatol Surg. 2007;33(5):607–13.PubMedCrossRefGoogle Scholar
  9. 9.
    Aguilera P, Puig S, Guilabert A, Julia M, Romero D, Vicente A. Prevalence study of nevi in children from Barcelona. Dermoscopy, constitutional and environmental factors. Dermatology. 2009;218(3):203–14.PubMedCrossRefGoogle Scholar
  10. 10.
    Scope A, Dusza SW, Marghoob AA, Satagopan JM, Braga Casagrande Tavoloni J, Psaty EL. Clinical and dermoscopic stability and volatility of melanocytic nevi in a population-based cohort of children in Framingham school system. J Invest Dermatol. 2011;131(8):1615–21.PubMedCrossRefGoogle Scholar
  11. 11.
    English DR, Armstrong BK. Melanocytic nevi in children. I. Anatomic sites and demographic and host factors. Am J Epidemiol. 1994;139(4):390–401.PubMedGoogle Scholar
  12. 12.
    Sigg C, Pelloni F. Frequency of acquired melanonevocytic nevi and their relationship to skin complexion in 939 schoolchildren. Dermatologica. 1989;179(3):123–8.PubMedCrossRefGoogle Scholar
  13. 13.
    Valiukeviciene S, Miseviciene I, Gollnick H. The prevalence of common acquired melanocytic nevi and the relationship with skin type characteristics and sun exposure among children in Lithuania. Arch Dermatol. 2005;141(5):579–86.PubMedCrossRefGoogle Scholar
  14. 14.
    Luther H, Altmeyer P, Garbe C, Ellwanger U, Jahn S, Hoffmann K, et al. Increase of melanocytic nevus counts in children during 5 years of follow-up and analysis of associated factors. Arch Dermatol. 1996;132(12):1473–8.PubMedCrossRefGoogle Scholar
  15. 15.
    Bauer J, Buttner P, Wiecker TS, Luther H, Garbe C. Risk factors of incident melanocytic nevi: a longitudinal study in a cohort of 1,232 young German children. Int J Cancer. 2005;115(1):121–6.PubMedCrossRefGoogle Scholar
  16. 16.
    Milne E, Simpson JA, English DR. Appearance of melanocytic nevi on the backs of young Australian children: a 7-year longitudinal study. Melanoma Res. 2008;18(1):22–8.PubMedCrossRefGoogle Scholar
  17. 17.
    Crane LA, Mokrohisky ST, Dellavalle RP, Asdigian NL, Aalborg J, Byers TE, et al. Melanocytic nevus development in Colorado children born in 1998: a longitudinal study. Arch Dermatol. 2009;145(2):148–56.PubMedCrossRefGoogle Scholar
  18. 18.
    Green A, Siskind V, Green L. The incidence of melanocytic naevi in adolescent children in Queensland, Australia. Melanoma Res. 1995;5(3):155–60.PubMedCrossRefGoogle Scholar
  19. 19.
    Darlington S, Siskind V, Green L, Green A. Longitudinal study of melanocytic nevi in adolescents. J Am Acad Dermatol. 2002;46(5):715–22.PubMedCrossRefGoogle Scholar
  20. 20.
    Siskind V, Darlington S, Green L, Green A. Evolution of melanocytic nevi on the faces and necks of adolescents: a 4 y longitudinal study. J Invest Dermatol. 2002;118(3):500–4.PubMedCrossRefGoogle Scholar
  21. 21.
    Westhafer J, Gildea J, Klepeiss S, Clarke L, Helm K. Age distribution of biopsied junctional nevi. J Am Acad Dermatol. 2007;56(5):825–7.PubMedCrossRefGoogle Scholar
  22. 22.
    Halpern AC, Guerry Dt, Elder DE, Trock B, Synnestvedt M, Humphreys T. Natural history of dysplastic nevi. J Am Acad Dermatol. 1993;29(1):51–7.PubMedCrossRefGoogle Scholar
  23. 23.
    Banky JP, Kelly JW, English DR, Yeatman JM, Dowling JP. Incidence of new and changed nevi and melanomas detected using baseline images and dermoscopy in patients at high risk for melanoma. Arch Dermatol. 2005;141(8):998–1006.PubMedCrossRefGoogle Scholar

Copyright information

© Springer- Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Tracey Liebman
    • 1
  • Natalia Jaimes Lopez
    • 1
  • Stephen W. Dusza
    • 1
    Email author
  1. 1.Dermatology ServiceMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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