Nevogenesis pp 49-57 | Cite as

The Dual Pathway of Nevogenesis

  • Iris Zalaudek
  • Alon Scope
  • Giuseppe Argenziano
  • Caterina Longo
  • Simonetta Piana
  • Caterina Carticalà
  • Ashfaq A. Marghoob


The evolution of melanocytic nevi is a complex, multifactorial process involving both constitutional and environmental factors. While histopathology remains the gold standard for diagnosis of melanocytic lesions, it is a mere cross-sectional view of nevus evolution at one point in time. Dermoscopy and more recently, reflectance confocal microscopy (RCM) are in vivo diagnostic techniques for the assessment of morphologic features of nevi; the fact that most dermoscopic features are well correlated with histopathologic criteria makes these methods valuable for observing gross tissue changes of nevi over time without need to biopsy (Table 4.1). Thus, dermoscopy and RCM have enriched profoundly our knowledge about the morphological variability of nevi and offered new insights into their evolution.


BRAF Mutation Melanocytic Nevus Reticular Pattern Reflectance Confocal Microscopy Epidermal Melanocyte 
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Copyright information

© Springer- Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Iris Zalaudek
    • 1
    • 2
  • Alon Scope
    • 4
    • 5
    • 6
  • Giuseppe Argenziano
    • 2
  • Caterina Longo
    • 2
  • Simonetta Piana
    • 7
  • Caterina Carticalà
    • 8
  • Ashfaq A. Marghoob
    • 3
  1. 1.Dermatology and Skin Cancer UnitMedical University of GrazGrazItaly
  2. 2.Dermatology and Skin Cancer UnitArcispedale Santa Maria Nuova, IRCCSReggio EmiliaItaly
  3. 3.Memorial Sloan-Kettering Skin Cancer CenterNew YorkUSA
  4. 4.Dermatology ServiceMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  5. 5.Department of DermatologySheba Medical CenterRamat GanIsrael
  6. 6.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  7. 7.Pathology UnitArcispedale Santa Maria NuovaReggio EmiliaItaly
  8. 8.Department of Oncologic DermatologySan Gallicano Dermatological InstituteRomeItaly

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