Nevogenesis pp 137-144 | Cite as

Malignant Transformation of Melanocytic Nevi

  • Alexander Marzuka-Alcalá
  • Hensin TsaoEmail author


Most cutaneous melanomas are thought to arise de novo from resident melanocytes in the skin. The nevus as a precursor lesion of melanoma has been a long-held clinical tenet, although there has been much debate on the molecular nature of nevi and its relationship to melanoma. The purpose of this chapter is to show evidence that nevi share common etiologic origins as melanoma and may therefore undergo the clinical observation of malignant transformation.


BRAF Mutation Cutaneous Melanoma Uveal Melanoma BRAF V600E Mutation Melanocytic Nevus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer- Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Yale DermatopathologyYale School of MedicineNew HavenUSA
  2. 2.Wellman Center for Photomedicine, Department of Dermatology and MGH Cancer CenterMassachusetts General HospitalBostonUSA

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