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Multimodal Diffuse Optical Imaging

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Biomedical Optical Imaging Technologies

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Diffuse optical imaging, particularly diffuse optical tomography (DOT), is an emerging clinical modality capable of providing unique functional information, at a relatively low cost, and with nonionizing radiation. Multimodal diffuse optical imaging has enabled a synergistic combination of functional and anatomical information: the quality of DOT reconstructions has been significantly improved by incorporating the structural information derived by the combined anatomical modality. In this chapter, we will review the basic principles of diffuse optical imaging, including instrumentation and reconstruction algorithm design. We will also discuss the approaches for multimodal imaging strategies that integrate DOI with clinically established modalities. The merit of the multimodal imaging approaches is demonstrated in the context of optical mammography, but the techniques described herein can be translated to other clinical scenarios such as brain functional imaging or muscle functional imaging.

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Authors and Affiliations

  1. Biomedical Engineering Department, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA

    Xavier Intes, Vivek Venugopal & Jin Chen

  2. Clinical Data Solutions, Office of Medical & Health Affairs, Philips Healthcare, Ramsey, NJ, 07446-2709, USA

    Fred S. Azar

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  1. Xavier Intes
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    Rongguang Liang

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Intes, X., Venugopal, V., Chen, J., Azar, F.S. (2013). Multimodal Diffuse Optical Imaging. In: Liang, R. (eds) Biomedical Optical Imaging Technologies. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28391-8_10

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