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Personalized Image-Based Radiation Dosimetry for Routine Clinical Use in Peptide Receptor Radionuclide Therapy: Pretherapy Experience

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Theranostics, Gallium-68, and Other Radionuclides

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 194))

Abstract

Patient-specific dose calculations are not routinely performed for targeted radionuclide therapy procedures, partly because they are time consuming and challenging to perform. However, it is becoming widely recognized that a personalized dosimetry approach can help plan treatment and improve understanding of the dose–response relationship. In this chapter, we review the procedures and essential elements of an accurate internal dose calculation and propose a simplified approach that is aimed to be practical for use in a busy nuclear medicine department.

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Authors and Affiliations

  1. Medical Imaging Research Group, University of British Columbia, Vancouver Coastal Health Research Institute, 828 West 10th Avenue, Vancouver, BC, V5Z 1M9, Canada

    Anna Celler, Joshua Grimes & Sergey Shcherbinin

  2. Department of Nuclear Medicine, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252, Szczecin, Poland

    Hanna Piwowarska-Bilska & Bozena Birkenfeld

Authors
  1. Anna Celler
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  2. Joshua Grimes
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  3. Sergey Shcherbinin
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  4. Hanna Piwowarska-Bilska
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  5. Bozena Birkenfeld
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Correspondence to Bozena Birkenfeld .

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Editors and Affiliations

  1. , THERANOSTICS Center for Molecular,, ENETS Center of Excellence, Zentralklinik Bad Berka, Bad Berka, 99437, Germany

    Richard P. Baum

  2. Inst. Kernchemie, Universität Mainz, Fritz-Straßmann-Weg 2, Mainz, 55128, Germany

    Frank Rösch

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Celler, A., Grimes, J., Shcherbinin, S., Piwowarska-Bilska, H., Birkenfeld, B. (2013). Personalized Image-Based Radiation Dosimetry for Routine Clinical Use in Peptide Receptor Radionuclide Therapy: Pretherapy Experience. In: Baum, R., Rösch, F. (eds) Theranostics, Gallium-68, and Other Radionuclides. Recent Results in Cancer Research, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27994-2_29

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  • DOI: https://doi.org/10.1007/978-3-642-27994-2_29

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