Abstract
Aim: The aim of this study is to ascertain the high somatostatin receptor (SSTR) uptake in spleen and to compare the uptake in spleen and splenosis using SSTR PET/CT using 68Ga-DOTATOC. Materials and Methods: SUVmax of spleen on 68Ga-DOTATOC SSTR PET/CT (acquired for initial staging) in 10 patients with known neuroendocrine neoplasm of pancreatic tail was analyzed. All patients underwent left pancreatectomy and splenectomy. Diagnosis of splenosis was confirmed on CT, and SUVmax was noted on follow-up SSTR PET/CT. Results: SUVmaxwas 28.8 ± 12.5 in normal spleen and 10.5 ± 4.3 in splenosis. Conclusion: The high uptake of 68Ga-DOTATOC (which has a high affinity to SSTR 2) in the spleen as compared to splenosis, which has a different histology, suggests white pulp as the probable site of high SSTR 2 expression.
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Kulkarni, H.R., Prasad, V., Kaemmerer, D., Hommann, M., Baum, R.P. (2013). High Uptake of 68Ga-DOTATOC in Spleen as Compared to Splenosis: Measurement by PET/CT. In: Baum, R., Rösch, F. (eds) Theranostics, Gallium-68, and Other Radionuclides. Recent Results in Cancer Research, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27994-2_19
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DOI: https://doi.org/10.1007/978-3-642-27994-2_19
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