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Epigenetics, Brain and Behavior pp 23–30Cite as

Plasticity of the Circadian System: Linking Metabolism to Epigenetic Control

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Part of the book series: Research and Perspectives in Neurosciences ((NEUROSCIENCE))

Abstract

Control of a large variety of neuronal, behavioral and physiological responses has been linked to the circadian clock, made possible through a transcriptional regulatory network that governs a significant portion of the genome. The harmonic oscillation of gene expression is paralleled by critical events of chromatin remodeling that appear to provide specificity and plasticity in circadian regulation. Accumulating evidence shows that the circadian epigenome appears to share intimate links with cellular metabolic processes, suggesting that the circadian epigenome might constitute the functional basis of tissue-specificity within biological pacemakers, specifically in neurons.

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Acknowledgments

We wish to thank all members of our laboratory for discussions and support. Work in the laboratory is supported by the National Institutes of Health, by the Inserm (Institut National de la Sante et la Recherche Medicale), France, and Sirtris Pharmaceutical Inc., a GSK Company.

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Authors and Affiliations

  1. Center for Epigenetics and Metabolism, U904 Inserm ‘Epigenetics and Neuronal Plasticity’, School of Medicine, University of California, Irvine, CA, 92697, USA

    Lorena Aguilar-Arnal, Loredana Zocchi, Selma Masri, Sayako Katada & Paolo Sassone-Corsi

Authors
  1. Lorena Aguilar-Arnal
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  2. Loredana Zocchi
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  3. Selma Masri
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  4. Sayako Katada
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  5. Paolo Sassone-Corsi
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Corresponding author

Correspondence to Paolo Sassone-Corsi .

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Editors and Affiliations

  1. School of Medicine, Center for Metabolism and Epigenetics, University of California at Irvine, Sprague Hall 324, Irvine, 92697, California, USA

    Paolo Sassone Corsi

  2. Recherche Therapeutique, Fondation IPSEN pour la, quai George Gorse 65, Boulogne Billancourt Cedex, 92650, France

    Yves Christen

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Aguilar-Arnal, L., Zocchi, L., Masri, S., Katada, S., Sassone-Corsi, P. (2012). Plasticity of the Circadian System: Linking Metabolism to Epigenetic Control. In: Sassone Corsi, P., Christen, Y. (eds) Epigenetics, Brain and Behavior. Research and Perspectives in Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27913-3_3

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