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Nucleosome Remodelling and Epigenome Diversification

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Epigenetics, Brain and Behavior

Part of the book series: Research and Perspectives in Neurosciences ((NEUROSCIENCE))

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Abstract

Nucleosome remodelling factors utilize chemical energy to disrupt histone-DNA interactions in nucleosomes. They catalyze a variety of structural changes ranging from complete nucleosome disassembly and the exchange of histone variants to the sliding of intact histone octamers along DNA. The essential involvement of some remodelling complexes in neuronal transcription programs is due to lineage-specific subunits that assure the selective targeting to neuronal promoters. In addition, nucleosome remodelers may contribute to the faithful silencing of competing transcription programs by maintaining the integrity and regularity of the nucleosomal fiber as a prerequisite for higher order chromatin organization.

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Acknowledgments

Research on nucleosome remodelling factors CHRAC and ACF in the author’s laboratory is funded by the Deutsche Forschungsgemeinschaft (DFG).

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Authors and Affiliations

  1. Adolf-Butenandt-Institute and Center of Integrated Protein Science, Ludwig-Maximilians-University, Schillerstr. 44, D-80336, Munich, Germany

    Peter B. Becker

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  1. Peter B. Becker
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Correspondence to Peter B. Becker .

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Editors and Affiliations

  1. School of Medicine, Center for Metabolism and Epigenetics, University of California at Irvine, Sprague Hall 324, Irvine, 92697, California, USA

    Paolo Sassone Corsi

  2. Recherche Therapeutique, Fondation IPSEN pour la, quai George Gorse 65, Boulogne Billancourt Cedex, 92650, France

    Yves Christen

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Becker, P.B. (2012). Nucleosome Remodelling and Epigenome Diversification. In: Sassone Corsi, P., Christen, Y. (eds) Epigenetics, Brain and Behavior. Research and Perspectives in Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27913-3_1

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