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On-Line Hemodialysis Monitoring: New Tools for Improving Safety, Tolerance and Efficacy

  • Chapter
Modeling and Control of Dialysis Systems

Abstract

Hemodialysis adequacy is a complex concept that encompasses largely the dialysis dose appraisal based on monthly blood-based urea Kt/V measurement. Renal replacement therapies should provide an efficient way to clear adequately larger molecular weight solutes, to restore normal salt, electrolytes and fluid balance, to correct salt-dependent hypertension, to improve hemodynamic stability and to reduce bio-incompatibility of the hemodialysis system. Targeting such ambitious objective is obviously under the clinical supervision and judgment of nephrologists and care givers. Monitoring and achievement of these targets as a part of a continuous quality improvement process is necessary to attain dialysis adequacy goals. This review aims to provide an overview of available online hemodialysis technologies, their current applications in clinic, and the potential for future developments in improving care of chronic kidney disease patients. In order to facilitate understanding of readers we choose to classify online monitoring devices based on their clinical action.

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References

  • Azar, A.T.: Biofeedback systems and adaptive control hemodialysis treatment. Saudi. J. Kidney Dis. Transpl. 19(6), 895–903 (2008)

    Google Scholar 

  • Akl, A.I., Sobh, M.A., Enab, Y.M., Tattersall, J.: Artificial intelligence: a new approach for prescription and monitoring of hemodialysis therapy. Am. J. Kidney Dis. 38(6), 1277–1283 (2001)

    Article  Google Scholar 

  • Al Saran, K., Sabry, A., Abdulghafour, M., Yehia, A.: Online conductiv-ity montoring of dialysis adequacy versus Kt/V derived from urea reduction ratio: a prospective study from a Saudi Center. Ren. Fail. 32(1), 36–40 (2010)

    Article  Google Scholar 

  • Andrulli, S., Colzani, S., Mascia, F., et al.: The role of blood volume reduction in the genesis of intradialytic hypotension. Am. J. Kidney Dis. 40(6), 1244–1254 (2002)

    Article  Google Scholar 

  • Argilés, A., Ficheux, A., Thomas, M., et al.: Precise quantification of dialysis using continuous sampling of spent dialysate and total dialysate volume measurement. Kidney Int. 52(2), 530–537 (1997)

    Article  Google Scholar 

  • Barth, R.H.: Dialysis by the numbers: the false promise of Kt/V. Semin. Dial. 2(4), 207–212 (1989)

    Article  MathSciNet  Google Scholar 

  • Barth, C., Boer, W., Garzoni, D., et al.: Characteristics of hypotension-prone haemodialysis patients: is there a critical relative blood volume? Nephrol. Dial. Transplant. 18(7), 1353–1360 (2003)

    Article  Google Scholar 

  • Basile, C., Giordano, R., Vernaglione, L., et al.: Efficacy and safety of haemodialysis treatment with the Hemocontrol biofeedback system: a prospective mediumterm study. Nephrol. Dial. Transplant. 16(2), 328–334 (2001a)

    Article  Google Scholar 

  • Basile, C., Giordano, R., Montanaro, A.: How large is the variability of relative blood volume during haemodialysis? Nephrol. Dial. Transplant. 16(2), 431–432 (2001b)

    Article  Google Scholar 

  • Bos, W.J., Bruin, S., van Olden, R.W., et al.: Cardiac and hemodynamic effects of hemodialysis and ultrafiltration. Am. J. Kidney Dis. 35(5), 819–826 (2000)

    Article  Google Scholar 

  • Bonforte, G., Dozio, B., Scanziani, R., et al.: Continuous on-line deter-mination of recirculation by thermodilution in hemodialysis patients. Int. J. Artif. Organs. 18(9), 526–529 (1995)

    Google Scholar 

  • Bosc, J.Y., LeBlanc, M., Garred, L.J., et al.: determination of blood recirculation rate in hemodialysis by a conductivity method. ASAIO J. 44(1), 68–73 (1998)

    Article  Google Scholar 

  • Brimble, K.S., Onge, J.S., Treleaven, D.J., Carlisle, E.J.: Comparison of volume of blood processed on haemodialysis adequacy measurement sessions vs regular non-adequacy sessions. Nephrol. Dial. Transplant. 17(8), 1470–1474 (2002)

    Article  Google Scholar 

  • Calzavara, P., Calconi, G., Da Rin, G., et al.: A new biosensor for continuous monitoring of the spent dialysate urea level in standard hemodialsis. Int. J. Artif. Organs. 21(3), 147–150 (1998)

    Google Scholar 

  • Canaud, B.: Adequacy target in hemodialysis. J. Nephrol. 17(Suppl. 8), S77–S86 (2004)

    Google Scholar 

  • Canaud, B., Bosc, J.Y., Cabrol, L., et al.: Urea as a marker of adequacy in hemodialysis: lesson from in vivo urea dynamics monitoring. Kidney Int. 76, S28–S40 (2000)

    Article  Google Scholar 

  • Canaud, B., Bosc, J.Y., Leblanc, M., et al.: Evaluation of high-fluxhemodiafiltration efficiency using an on-line urea monitor. Am. J. Kidney Dis. 31(1), 74–80 (1998a)

    Article  Google Scholar 

  • Canaud, B., Bosc, J.Y., Leblanc, M., et al.: On-line dialysis quantification in acutely ill patients: preliminary clinical experience with a multipurpose urea sensor monitoring device. ASAIO J. 44(3), 184–190 (1998b)

    Article  Google Scholar 

  • Canaud, B., Bosc, J.Y., Leblanc, M., et al.: A simple and accurate method todetermine equilibrated post-dialysis urea concentration. Kidney Int. 51(6), 2000–2005 (1997)

    Article  Google Scholar 

  • Chesterton, L., Lambie, S.H., Hulme, L.J., et al.: Online measurement of haemoglobin concentration. Nephrol. Dial. Transplant. 20(9), 1951–1955 (2005)

    Article  Google Scholar 

  • Covic, A., Goldsmith, D.J., Hill, K., et al.: Urea kinetic modeling: are any of the ’bedside’ Kt/V formulae reliable enough? Nephrol. Dial. Transplant. 13(12), 3138–3146 (1998)

    Article  Google Scholar 

  • Daugirdas, J.T.: Dialysis hypotension: a hemodynamic analysis. Kidney Int. 39(2), 233–246 (1991)

    Article  Google Scholar 

  • Daugirdas, J.T., Schneditz, D.: Overestimation of hemodialysis dose depends on dialysis efficiency by regional blood flow but not by conventional two pool urea kinetic analysis. ASAIO J. 41(3), M719–M724 (1995)

    Article  Google Scholar 

  • Davenport, A.: Can advances in hemodialysis machine technology prevent intradialytic hypotension? Semin. Dial. 22(3), 231–236 (2009)

    Article  Google Scholar 

  • Depner, T.A., Daugirdas, J.T.: Equations for normalized protein catabolic rate based on two-point modeling of hemodialysis urea kinetics. J. Am. Soc. Nephrol. 7(5), 780–785 (1996)

    Google Scholar 

  • Del Vecchio, L., Di Filippo, S., Andrulli, S., et al.: Conductivity: on-line monitoring of dialysis adequacy. Int. J. Artif. Organs. 21(9), 521–525 (1998)

    Google Scholar 

  • Depner, T.A., Keshaviah, P.R., Ebben, J.P., et al.: Multicenter clinical va-lidation of an on-line monitor of dialysis adequacy. J. Am. Soc.-Nephrol. 7(3), 464–471 (1996)

    Google Scholar 

  • Desai, A.A., Bolus, R., Nissenson, A., et al.: Identifying best practices in dialysis care: results of cognitive interviews and a national survey of dialysis providers. Clin. J. Am. Soc. Nephrol. 3(4), 1066–1076 (2008)

    Article  Google Scholar 

  • Di Filippo, S., Andrulli, S., Manzoni, C., et al.: On-line assessment of delivered dialysis dose. Kidney Int. 54(1), 263–267 (1998)

    Article  Google Scholar 

  • Di Filippo, S., Pozzoni, P., Manzoni, C., et al.: Relationship between urea clearance and ionic dialysance determined using a single-step conductivity profile. Kidney Int. 68(5), 2389–2395 (2005)

    Article  Google Scholar 

  • Dossabhoy, N.R., Ram, S.J., Nassar, R., et al.: Stenosis surveillance of hemodialysis grafts by duplex ultrasound reduces hospitalizations and cost of care. Semin. Dial. 18(6), 550–557 (2005)

    Article  Google Scholar 

  • Dominic, S.C., Ramachandran, S., Somiah, S., et al.: Quenching the thirst in dialysis patients. Nephron 73(4), 597–600 (1996)

    Article  Google Scholar 

  • Eknoyan, G., Beck, G.J., Cheung, A.K., et al.: Effect of dialysis dose and membrane flux in maintenance hemodialysis. N. Engl. J. Med. 347(25), 2010–2019 (2002)

    Article  Google Scholar 

  • Fridolin, I., Magnusson, M., Lindberg, L.G.: On-line monitoring of solutes in dialysate using absorption of ultraviolet radiation: technique description. Int. J. Artif. Organs. 25(8), 748–761 (2002)

    Google Scholar 

  • Garred, L.J., Canaud, B., Argiles, A., et al.: Protein catabolic rate determi-nation from a single measurement of dialyzed urea. ASAIO J. 41(3), M804–M809 (1995)

    Article  Google Scholar 

  • Garred, L.J.: Dialysate-based kinetic modeling. Adv. Ren. Replace Ther. 2(4), 305–318 (1995)

    Google Scholar 

  • Garred, L.J., Rittau, M., McCready, W., Canaud, B.: Urea kinetic model-ling by partial dialysate collection. Int. J. Artif. Organs. 12(2), 96–102 (1989)

    Google Scholar 

  • Gabrielli, D., Krystal, B., Katzarski, K., et al.: Improved intradialytic sta-bility during haemodialysis with blood volume-controlled ultrafil-tration. J. Nephrol. 22(2), 232–240 (2009)

    Google Scholar 

  • Goldau, R., Kuhlmann, U., Samadi, N., et al.: Ionic dialysance measure-ment is urea distribution volume dependent: a new approach to better results. Artif. Organs. 26(4), 321–332 (2002)

    Article  Google Scholar 

  • Gotch, F.A., Sargent, J.A.: A mechanistic analysis of the National Cooperative Dialysis Study (NCDS). Kidney Int. 28(3), 526–534 (1985)

    Article  Google Scholar 

  • Greene, T., Daugirdas, J., Depner, T., et al.: Hemodialysis Study Group. Association of achieved dialysis dose with mortality in the hemo-dialysis study: an example of "dose-targeting bias”. J. Am. Soc.-Nephrol. 16(11), 3371–3380 (2005)

    Article  Google Scholar 

  • Gross, M., Maierhofer, A., Tetta, C., et al.: Online clearance measure-ment in high-efficiency hemodiafiltration. Kidney Int. 72(12), 1550–1553 (2007)

    Article  Google Scholar 

  • Hakim, R.M., Depner, T.A., Parker, T.F.: Adequacy of hemodialysis. Am. J. Kidney Dis. 20(2), 107–123 (1992)

    Google Scholar 

  • Hartvigsen, G., Johansen, M.A., Hasvold, P., et al.: Challenges in tele-medicine and eHealth: lessons learned from 20 years with tele-medicine in Tromso. Stud. Health Technol. Inform. 129(pt. 1), 82–86 (2007)

    Google Scholar 

  • Hernandez-Herrera, G., Martin-Malo, A., Rodriguez, M., Aljama, P.: Assessment of the length of each hemodialysis session by on-line dialysate urea monitoring. Nephron 89(1), 37–42 (2001)

    Article  Google Scholar 

  • Horácek, J., Sulková, S.D., Fortová, M., et al.: Resting energy expendi-ture and thermal balance during isothermic and thermoneutral-haemodialysis: heat production does not explain increased body temperature during haemodialysis. Nephrol. Dial. Transplant. 22(12), 3553–3560 (2007)

    Article  Google Scholar 

  • Jurkiewicz, M., Solé, S., Almirall, J., et al.: Validation of an automatic urea analyser used in the continuous monitoring of hemodialysis parameters. Analyst 121(7), 959–963 (1996)

    Article  Google Scholar 

  • Johner, C., Chamney, P.W., Schneditz, D., Krämer, M.: Evaluation of an ultrasonic blood volume monitor. Nephrol. Dial. Transplant. 13(8), 2098–2103 (1998)

    Article  Google Scholar 

  • Katopodis, K.P., Hoenich, N.A.: Accuracy and clinical utility of dialysis dose measurement using online ionic dialysance. Clinical Nephrology 57(3), 215–220 (2002)

    Google Scholar 

  • Krepel, H.P., Nette, R.W., Akçahüseyin, E., et al.: Variability of relative blood volume during haemodialysis. Nephrol. Dial. Transplant. 15(5), 673–679 (2000)

    Article  Google Scholar 

  • Kloppenburg, W.D., Stegeman, C.A., Hooyschuur, M., et al.: Assessing dialysis adequacy and dietary intake in the individual hemodialysis patient. Kidney Int. 55(5), 1961–1969 (1999)

    Article  Google Scholar 

  • Krivitski, N., Schneditz, D.: Arteriovenous vascular access flow meas-urement: accuracy and clinical implications. Contrib. Nephrol. 142, 269–284 (2004)

    Article  Google Scholar 

  • Krivitski, N.M.: Novel method to measure access flow during hemo-dialysis by ultrasound velocity dilution technique. ASAIO J. 41(3), M741–M745 (1995)

    Article  Google Scholar 

  • Kuhn, C., Saile, P., Osten, B., et al.: The blood temperature monitor of the new 5008 dialysis machine overestimates vascular access re-circulation. JASN Abstracts (F-PO1048) (2006)

    Google Scholar 

  • Lameire, N., Van Biesen, W., Vanholder, R.: Did 20 years of techno-logical innovations in hemodialysis contribute to better patient out-comes? Clin. J. Am. Soc. Nephrol. 4(Suppl. 1), S30–S40 (2009)

    Article  Google Scholar 

  • Lee, W.C., Tsai, C.J., Huang, C.C., et al.: Assessment of dialysis adequacy using the dialysate urea monitor: preliminary experience of the dialysate urea monitor. Ren. Fail. 19(6), 789–797 (1997)

    Article  Google Scholar 

  • Lim, P.S., Lee, H.P., Kho, B., et al.: Evaluation of pre- and postdilutional on-line hemodiafiltration adequacy by partial dialysate quantification and on-line urea monitor. Blood Purif. 17(4), 199–205 (1999)

    Article  Google Scholar 

  • Lindsay, R.M., Huang, S.H., Sternby, J., Hertz, T.: The measurement of hemodialysis access blood flow by a conductivity step method. Clin. J. Am. Soc. Nephrol. 5(9), 1602–1606 (2010)

    Article  Google Scholar 

  • Lindsay, R.M., Sternby, J., Olde, B., et al.: Hemodialysis blood access flow rates can be estimated accurately from on-line dialysate urea measurements and the knowledge of effective dialyzer urea clear-ance. Clin. J. Am. Soc. Nephrol. 1(5), 960–964 (2006)

    Article  Google Scholar 

  • Leypoldt, J.K., Cheung, A.K., Steuer, R.R., et al.: Determination of circu-lating blood volume by continuously monitoring hematocrit during hemodialysis. J. Am. Soc. Nephrol. 6(2), 214–219 (1995)

    Google Scholar 

  • Locatelli, F., Di Filippo, S., Manzoni, C., et al.: Monitoring sodium re-moval and delivered dialysis by conductivity. Int. J. Artif. Organs. 18(11), 716–721 (1995)

    Google Scholar 

  • Locatelli, F.: Dose of dialysis, convection and haemodialysis patients outcome: what the HEMO study doesn’t tell us: the European viewpoint. Nephrol. Dial. Transplant. 18(6), 1061–1065 (2003)

    Article  Google Scholar 

  • Locatelli, F., Buoncristiani, U., Canaud, B., et al.: Haemodialysis with on-line monitoring equipment: tools or toys? Nephrol. Dial. Transplant. 20(1), 22–33 (2005)

    Article  Google Scholar 

  • Luman, M., Jerotskaja, J., Lauri, K., Fridolin, I.: Dialysis dose and nutri-tion assessment by optical on-line dialysis adequacy monitor. Clin. Nephrol. 72(4), 303–311 (2009)

    Google Scholar 

  • Mancini, E., Mambelli, E., Irpinia, M., et al.: Prevention of dialysis hy-potension episodes using fuzzy logic control system. Nephrol. Dial. Transplant. 22(5), 1420–1427 (2007)

    Article  Google Scholar 

  • Mambelli, E., Mancini, E., Santoro, A.: A continuous and non-invasive arterial pressure monitoring system in dialysis patients. Nephron Clin. Pract. 107(4), C170–C176 (2007)

    Article  Google Scholar 

  • Maggiore, Q., Pizzarelli, F., Santoro, A., et al.: Study Group of Thermal Balance and Vascular Stability. The effects of control of thermal balance on vascular stability in hemodialysis patients: results of the European randomized clinical trial. Am. J. Kidney Dis. 40(2), 280–290 (2002)

    Article  Google Scholar 

  • Marcelli, D., Moscardó, V., Steil, H., et al.: Data management and quality assurance for dialysis network. Contrib. Nephrol. 137, 293–299 (2002)

    Article  Google Scholar 

  • McIntyre, C.W., Lambie, S.H., Taal, M.W., Fluck, R.J.: Assessment of haemodialysis adequacy by ionic dialysance: intra-patient variability of delivered dose. Nephrol. Dial. Transplant. 18(3), 559–562 (2003a)

    Article  Google Scholar 

  • McIntyre, C.W., Lambie, S.H., Fluck, R.J.: Biofeedback controlled haemodialysis (BF-HD) reduces symptoms and increases both haemodynamic tolerability and dialysis adequacy in non-hypotension prone stable patients. Clin. Nephrol. 60(2), 105–112 (2003b)

    Google Scholar 

  • McMahon, M.P., Campbell, S.B., Shannon, G.F., et al.: A non-invasive continuous method of measuring blood volume during haemodi-alysis using optical techniques. Med. Eng. Phys. 18(2), 105–109 (1996)

    Article  Google Scholar 

  • Mercadal, L., Servais, A., Venditto, M., et al.: Measuring plasma conduc-tivity to detect sodium load in hemodialysis patients. Clin. J. Am. Soc. Nephrol. 3(3), 743–746 (2008)

    Article  Google Scholar 

  • Mercadal, L., Challier, E., Cluzel, P., et al.: Detection of vascular access stenosis by measurement of access blood flow from ionic dialy-sance. Blood Purif. 20(2), 177–181 (2002)

    Article  Google Scholar 

  • Mercadal, L., Petitclerc, T., Jaudon, M.C., et al.: Is ionic dialysance a valid parameter for quantification of dialysis efficiency? Artif. Organs. 22(12), 1005–1009 (1998)

    Article  Google Scholar 

  • Micromedia: Biosensor for on-line dialysis efficiency monitoring. EU Ga-teway Program, http://www.hemodia.com/images/posterEU-Gateway.pdf

  • Mitra, S., Chamney, P., Greenwood, R., Farrington, K.: Linear decay of relative blood volume during ultrafiltration predicts hemodynamic instability. Am. J. Kidney Dis. 40(3), 556–565 (2002)

    Article  Google Scholar 

  • Moret, K., Hassell, D., Kooman, J.P., et al.: Ionic mass balance and blood volume preservation during a high, standard, and individualized dialysate sodium concentration. Nephrol. Dial. Transplant. 17(8), 1463–1469 (2002)

    Article  Google Scholar 

  • Montagnac, R., Vitry, F., Rehn, Y., et al.: HemoCue: preliminary considerations about its use in hemodialysis. Nephrol. Ther. 3(2), 60–64 (2007)

    Article  Google Scholar 

  • Navino, C., Tetta, C., Tessore, V., Verzetti, G.: Assessment of efficiency using on-line urea kinetic modeling in hemodiafiltration. ASAIO J. 44(5), M565–M568 (1998)

    Article  Google Scholar 

  • NKF-K/DOQI, Clinical Practice Guidelines for Hemodialysis Ade quacy: update. Am. J. Kidney Dis. 37(Suppl. 1), S7–S64 (2001)

    Google Scholar 

  • Paolini, F., Mancini, E., Bosetto, A., Santoro, A.: Hemoscan: a dialysis machine integrated blood volume monitor. Int. J. Artif. Organs. 18(9), 487–494 (1995)

    Google Scholar 

  • Pedrini, L.A., De Cristofaro, V.: On-line mixed hemodiafiltration with a feedback for ultrafiltration control: effect on middle-molecule removal. Kidney Int. 64(4), 1505–1513 (2003)

    Article  Google Scholar 

  • Pedrini, L.A., Cozzi, G., Faranna, P., et al.: Transmembrane pressure modulation in high-volume mixed hemodiafiltration to optimize efficiency and minimize protein loss. Kidney Int. 69(3), 573–579 (2006)

    Article  Google Scholar 

  • Pérgola, P.E., Habiba, N.M., Johnson, J.M.: Body temperature regulation during hemodialysis in long-term patients: is it time to change di-alysate temperature prescription? Am. J. Kidney Dis. 44(1), 155–165 (2004)

    Article  Google Scholar 

  • Racki, S., Zaputović, L., Maleta, I., et al.: Assessment of hemodialysis adequacy by ionic dialysance: comparison to standard method of urea removal. Ren. Fail. 27(5), 601–604 (2005)

    Article  Google Scholar 

  • Ridel, C., Osman, D., Mercadal, L., et al.: Ionic dialysance: a new valid parameter for quantification of dialysis efficiency in acute renal failure? Intensive Care Med. 33(3), 460–465 (2007)

    Article  Google Scholar 

  • Ronco, C., Brendolan, A., Milan, M., et al.: Impact of biofeedback-induced cardiovascular stability on haemodialysis tolerance and ef-ficiency. Kidney Int. 58(2), 800–808 (2000)

    Article  Google Scholar 

  • Ronco, C., Bellomo, R.: Central circulation, peripheral circulation and recirculation. Blood Purif. 15(4-6), 334–335 (1997)

    Article  Google Scholar 

  • Rodriguez, H.J., Domenici, R., Diroll, A., Goykhman, I.: Assessment of dry weight by monitoring changes in blood volume during hemo-dialysis using Crit-Line. Kidney Int. 68(2), 854–861 (2005)

    Article  Google Scholar 

  • Rumpsfeld, M., Arild, E., Norum, J., Breivik, E.: Telemedicine in haemo-dialysis: a university department and two remote satellites linked together as one common workplace. J. Telemed. Tele-care 11(5), 251–255 (2005)

    Article  Google Scholar 

  • Santoro, A., Mancini, E., Basile, C., et al.: Blood volume controlled hemodialysis in hypotension-prone patients: a randomized, multicenter controlled trial. Kidney Int. 62(3), 1034–1045 (2002)

    Article  Google Scholar 

  • Santoro, A., Mancini, E., Canova, C., Mambelli, E.: Thermal balance in convective therapies. Nephrol. Dial. Transplant. 18(Suppl 7), vii41–vii45 (2003)

    Google Scholar 

  • Santoro, A., Mancini, E., Paolini, F., et al.: Blood volume regulation during hemodialysis. Am. J. Kidney Dis. 32(5), 739–748 (1998)

    Article  Google Scholar 

  • Sands, J., Glidden, D., Miranda, C.: Access flow measured during he-modialysis. ASAIO J. 42(5), M530–M532 (1996)

    Article  Google Scholar 

  • Schmidt, R., Roeher, O., Hickstein, H., Korth, S.: Prevention of haemodi-alysis-induced hypotension by biofeedback control of ultrafiltration and infusion. Nephrol. Dial. Transplant. 16(3), 595–603 (2001)

    Article  Google Scholar 

  • Sehgal, A.R., Leon, J.B., Siminoff, L.A., et al.: Improving the quality of hemodialysis treatment: a community-based randomized con-trolled trial to overcome patient-specific barriers. JAMA 287(15), 1961–1967 (2002)

    Article  Google Scholar 

  • Schneditz, D., Ronco, C., Levin, N.: Temperature control by the blood temperature monitor. Semin. Dial. 16(6), 477–482 (2003)

    Article  Google Scholar 

  • Schneditz, D., Wang, E., Levin, N.W.: Validation of haemodialysis re-circulation and access blood flow measured by thermodilution. Nephrol. Dial. Transplant. 14(2), 376–383 (1999)

    Article  Google Scholar 

  • Shoji, T., Tsubakihara, Y., Fujii, M., Imai, E.: Hemodialysis-associated hypotension as an independent risk factor for two-year mortality in hemodialysis patients. Kidney Int. 66(3), 1212–1220 (2004)

    Article  Google Scholar 

  • Spiegel, B., Bolus, R., Desai, A.A., et al.: Dialysis Practices That Distinguish Facilities with Below- versus Above-Expected Mortality. Clin. J. Am. Soc. Nephrol. 5(11), 2024–2033 (2010)

    Article  Google Scholar 

  • Stoffel, M.P., Barth, C., Lauterbach, K.W., Baldamus, C.A.: Evidence-based medical quality management in dialysis: Improvement of hemodialysis adequacy. Clin. Nephrol. 62(3), 219–225 (2004)

    Google Scholar 

  • Tattersall, J., Martin-Malo, A., Pedrini, L., et al.: EBPG guideline on di-alysis strategies. Nephrol. Dial. Transplant. 22(Suppl. 2), ii5–ii21 (2007)

    Google Scholar 

  • Tislér, A., Akócsi, K., Borbás, B., et al.: The effect of frequent or occa-sional dialysis-associated hypotension on survival of patients on maintenance haemodialysis. Nephrol. Dial. Transplant. 18(12), 2601–2605 (2003)

    Article  Google Scholar 

  • Tonelli, M., Astephen, P., Andreou, P., et al.: Blood volume monitoring in intermittent hemodialysis for acute renal failure. Kidney Int. 62(3), 1075–1080 (2002)

    Article  Google Scholar 

  • Tordoir, J., Canaud, B., Haage, P., et al.: EBPG on Vascular Access. Nephrol. Dial. Transplant. 22(Suppl. 2), ii88–ii117 (2007)

    Google Scholar 

  • Uhlin, F., Fridolin, I., Lindberg, L.G., Magnusson, M.: Estimation of delivered dialysis dose by on-line monitoring of the ultraviolet absorbance in the spent dialysate. Am. J. Kidney Dis. 41(5), 1026–1036 (2003)

    Article  Google Scholar 

  • Válek, M., Lopot, F., Polakovic, V.: Arteriovenous fistula, blood flow, cardiac output, and left ventricle load in hemodialysis patients. ASAIO J. 56(3), 200–203 (2010)

    Article  Google Scholar 

  • Vaussenat, F., Canaud, B., Bosc, J.Y., et al.: Intradialytic glucose infusion increases polysulphone membrane permeability and post-dilutionalhaemodiafiltration performances. Nephrol. Dial. Transplant. 15(4), 511–516 (2000)

    Article  Google Scholar 

  • Vaussenat, F., Bosc, J.Y., LeBlanc, M., Canaud, B.: Data acquisition sy-tem for dialysis machines. A model for membrane hydraulic permeability. ASAIO J. 43(6), 910–915 (1997)

    Article  Google Scholar 

  • Waniewski, J.: Mathematical modeling of fluid and solute transport in hemodialysis and peritoneal dialysis. Journal of Membrane Science 274(1-2), 24–37 (2006)

    Article  Google Scholar 

  • Wang, E., Schneditz, D., Kaufman, A.M., Levin, N.W.: Sensitivity and specificity of the thermodilution technique in detection of access recirculation. Nephron 85(2), 134–141 (2000)

    Article  Google Scholar 

  • Woods, H.F.: Variability of relative blood volume during haemodialysis? Nephrol. Dial. Transplant. 16(2), 430–431 (2001)

    Article  Google Scholar 

  • Wolkotte, C., Hassell, D.R., Moret, K., et al.: Blood volume control by biofeedback and dialysis-induced symptomatology. A short-term clinical study. Nephron 92(3), 605–609 (2002)

    Article  Google Scholar 

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Correspondence to Bernard Canaud .

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Canaud, B., Granger, A., Chenine-Khoualef, L., Patrier, L., Morena, M., Leray-Moragués, H. (2013). On-Line Hemodialysis Monitoring: New Tools for Improving Safety, Tolerance and Efficacy. In: Azar, A. (eds) Modeling and Control of Dialysis Systems. Studies in Computational Intelligence, vol 405. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27558-6_1

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