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Antisense-Mediated Reduction of Eukaryotic Noncoding RNAs

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From Nucleic Acids Sequences to Molecular Medicine

Part of the book series: RNA Technologies ((RNATECHN))

Abstract

The human genome has been demonstrated to be transcribed largely as noncoding RNAs. Accumulating evidence suggests important roles for many noncoding RNAs in different biological processes as well as in human diseases. Thus, it is important to be able to manipulate the expression of the noncoding RNAs, both for biological functionalization of these RNAs and for treatment of diseases related to noncoding RNAs. In this review, we summarize the approaches for reducing expression of noncoding RNAs in different eukaryotic organisms and the insights provided into the functions of these noncoding RNAs.

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Acknowledgments

We apologize to those whose paper could not be cited due to space limitations. We thank Donna Parrett for excellent editing.

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Authors and Affiliations

  1. Department of Core Antisense Research, ISIS Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA, 92010, USA

    Xue-hai Liang, Timothy A. Vickers & Stanley T. Crooke

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  1. Xue-hai Liang
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  2. Timothy A. Vickers
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  3. Stanley T. Crooke
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Correspondence to Xue-hai Liang .

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  1. Institute of Chemistry/Biochemistry, Free University Berlin, Thielallee 63, Berlin, 14195, Berlin, Germany

    Volker A. Erdmann

  2. Inst. Bioorganic Chemistry, PAN Poznan, ul. Z. Noskowskiego 12/14, Poznan, 61-704, Poland

    Jan Barciszewski

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© 2012 Springer-Verlag Berlin Heidelberg

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Liang, Xh., Vickers, T.A., Crooke, S.T. (2012). Antisense-Mediated Reduction of Eukaryotic Noncoding RNAs. In: Erdmann, V., Barciszewski, J. (eds) From Nucleic Acids Sequences to Molecular Medicine. RNA Technologies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27426-8_8

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