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Targeting Non-coding RNAs for Cancer Therapy

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From Nucleic Acids Sequences to Molecular Medicine

Part of the book series: RNA Technologies ((RNATECHN))

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Abstract

Cancer remains one of the leading causes of morbidity and mortality, with limited progress in the development of cancer cell-specific, targeted, long-term therapeutic strategies. In the past decade, non-coding RNAs have emerged as novel and key modulators of cellular gene expression influencing both the transcriptional and posttranscriptional output. Seminal contributions of non-coding RNAs during development and disease have been described in many eukaryotic species including humans. To date, several different classes of non-coding RNA have been identified and can be broadly categorized mainly based on their size, structural characteristics, and proteins involved in their biogenesis. Recently, microRNAs, a small non-coding RNA species, and various long non-coding RNAs have been implicated and studied widely in multiple aspects of cancer initiation, progression, and metastasis. Understanding the mechanistic aspects of non-coding RNAs might hold the key, not only to decipher what goes awry in cancer but also most importantly to devise novel targeted therapeutic strategies in the coming years. In this chapter, we will provide a brief overview of non-coding RNAs, with emphasis on those RNAs whose levels are modulated during carcinogenesis.

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Authors and Affiliations

  1. Institute of Molecular Genetics, CNRS, UMR5535, 1919 route de Mende, 34293, Montpellier, Cedex 5, France

    Satya K. Kota

  2. Department of Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02115, USA

    Savithri Balasubramanian

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  1. Satya K. Kota
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Correspondence to Satya K. Kota .

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  1. Institute of Chemistry/Biochemistry, Free University Berlin, Thielallee 63, Berlin, 14195, Berlin, Germany

    Volker A. Erdmann

  2. Inst. Bioorganic Chemistry, PAN Poznan, ul. Z. Noskowskiego 12/14, Poznan, 61-704, Poland

    Jan Barciszewski

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Kota, S.K., Balasubramanian, S. (2012). Targeting Non-coding RNAs for Cancer Therapy. In: Erdmann, V., Barciszewski, J. (eds) From Nucleic Acids Sequences to Molecular Medicine. RNA Technologies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27426-8_24

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