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RNAissance

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From Nucleic Acids Sequences to Molecular Medicine

Part of the book series: RNA Technologies ((RNATECHN))

Abstract

Half a century ago, at the dawn of molecular biology, few investigators realized the potential of RNA in cellular regulation and function. After a very long lag phase, the quantitative and qualitative evidence for the significance of non-protein-coding RNA (npcRNA) is now overwhelming. In the search for disease-causing gene alterations, RNA genes must be considered equally with protein-coding genes.

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Notes

  1. 1.

    The size cutoff for small RNAs used to be about 500 nt to include SRP RNA (300 nt), 7SK RNA (332 nt), MRP RNA (287 nt), and small nuclear RNAs (depending on species), etc. Large or long RNAs were defined as being in the size range of mRNAs, sometimes even displaying mRNA-like attributes (e.g., processing, polyadenylation) but devoid of a functional open reading frame (Brosius and Tiedge 2004). The first publications on microRNAs (miRNAs) correctly designated them as tiny RNAs to discriminate them from the larger small RNAs (Ambros 2001; Lau et al. 2001; Ruvkun 2001) With time, they were more laxly addressed as small RNAs, and hence, the “new” small RNAs had to be distinguished from the “old” small RNAs, simply by stretching the latter and moving the cutoff to about 200 nt. The fact that numerous small RNAs designated as such in dozens to hundreds of previous publications are now supposed to be found under long RNAs is unfortunate.

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  1. Institute of Experimental Pathology, ZMBE, University of Münster, Von-Esmarch-Street 56, 48149, Münster, Germany

    Juergen Brosius

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  1. Institute of Chemistry/Biochemistry, Free University Berlin, Thielallee 63, Berlin, 14195, Berlin, Germany

    Volker A. Erdmann

  2. Inst. Bioorganic Chemistry, PAN Poznan, ul. Z. Noskowskiego 12/14, Poznan, 61-704, Poland

    Jan Barciszewski

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Brosius, J. (2012). RNAissance. In: Erdmann, V., Barciszewski, J. (eds) From Nucleic Acids Sequences to Molecular Medicine. RNA Technologies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27426-8_1

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