Abstract
The key steps included the synthesis of enantiomerically pure dioxolane cores through lipase resolution of a racemic precursor, the introduction of an alkynyl sidechain on a 1,2-dioxolane via a Corey-Fuchs homologation, and the introduction of the sidechain of the natural product through Pd-catalyzed sp 2/sp 3 cross-coupling.
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Reference
Xie X-G, Wu X-W, Lee H-K, Peng X-S, Wong HNC (2010) Chem Eur J 16:6933–6941
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© 2012 Springer-Verlag Berlin Heidelberg
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Sun, XY. (2012). Conclusion. In: Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B. Springer Theses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27195-3_3
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DOI: https://doi.org/10.1007/978-3-642-27195-3_3
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