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Introduction

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Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B

Part of the book series: Springer Theses ((Springer Theses))

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Abstract

Organic peroxides are compounds containing an O–O bond. The O–O group is called the peroxide group. The peroxide bond is one of the weakest bonds in organic molecules, with BDE of approximately 34 kcal/mol (C–C: 81 kcal/mol, C–H: 98 kcal/mol, C–O: 79 kcal/mol, C–N: 66 kcal/mol). The O–O bond is unstable and easily splits into reactive radicals via homolytic cleavage. For this reason, peroxides are found in nature only in small quantities, in water, atmosphere, plants, animals and man. According to the substitution patterns, organic peroxides can be classified into hydroperoxides, acyclic dialkyl peroxide and cyclic peroxides.

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  1. Laboratory of Organic Chemistry, ETH Zürich, Wolfgang-Paulistrasse 10, ETH Hönggerberg HCI E 306, 8093, Zürich, Switzerland

    Dr. Xiao-Yu Sun

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Sun, XY. (2012). Introduction. In: Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B. Springer Theses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27195-3_1

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