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Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 124))

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Abstract

The viewpoint that cancer is a genetic disease has been widely accepted by modern medicine. Therefore, seeking out the useful information from gene microarray data sets becomes a popular study. But because the data sets on gene expression have the features of small sample, high dimensionality and nonlinearity, traditional statistical methods face a challenge of “curse of dimensionality” and “problem of small sample size”. As a result, dimensionality reduction becomes the key to pattern recognition. This article uses Multidimensional Scaling and Laplacian Eigenmaps to reduce the dimensionality of the cancer data, and then uses Support Vector Machine to classify the data, Laplacian Eigenmaps achieving better result.

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References

  1. Tenenbaum, J.B., de Silvav, Langford, J.C.: A global geometric framework for nonlinear dimensionality reduction. Science 290(5500), 2319–2323 (2000)

    Article  Google Scholar 

  2. Belkinm, Niyogip: Laplacian eigenmaps for dimensionality reduction and data rep resentation. University of Chicago, Chicago (2001)

    Google Scholar 

  3. van der Maaten, L.J.P.: An Introduction to Dimensionality Reduction Using Matlab, MICC, Maastricht University (2007)

    Google Scholar 

  4. Vapnik, V.N.: The nature of statistical learning theory. Springer, New York (1995)

    Book  MATH  Google Scholar 

  5. Alon, U., Barkai, N., Notterman, D.A., Gish, K., Mack, D., Levine, A.J.: Broad patterns of gene epression revealed by clustering analysis of tumor and normal colon tissues by oligonucleotide arrays. Cell Biology, 6745–6750 (1999)

    Google Scholar 

  6. Liu, Y., Zhou, J., Chen, Y.: Ensemble Classification for cancer data. BMEI, 269–273 (2008)

    Google Scholar 

  7. Furey, T.S., Grostoamomo, N., Diffy, N.: Support vector machine classification and validation of cancer tissue samples using microarray expression data. Bioionformatics 16, 906–914 (2000)

    Article  Google Scholar 

  8. Ben-Dor, A., Bruhn, L., Friedman, N., Nachman, I., Schummer, M., Yakhini, N.: Tissue classification with gene expression profiles. Computational Biology 7, 559–584 (2000)

    Article  Google Scholar 

  9. Nguyen, D.V., Rocke, D.M.: Tumor classification by partial least squares using microarray gene expression data. Bioinformatics 18(1), 39–50 (2002)

    Article  Google Scholar 

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Zuoling, L., Guirong, W. (2012). Dimensionality Reduction for Colon Data. In: Qian, Z., Cao, L., Su, W., Wang, T., Yang, H. (eds) Recent Advances in Computer Science and Information Engineering. Lecture Notes in Electrical Engineering, vol 124. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25781-0_21

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  • DOI: https://doi.org/10.1007/978-3-642-25781-0_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-25780-3

  • Online ISBN: 978-3-642-25781-0

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