Abstract
This study presents a computer-aided volumety (CAV) scheme that estimates the necrosis volumes in the focal liver lesions based on the multi-phase hepatic CT images for estimation of liver tumor burden. We developed a CAV scheme that consisted of the following three major steps: registration of multi-phase series based upon the portal-venous phase images, modeling of the concentration-time curve and thus estimattion of the arterial and portal-venous blood flow, and segmentation of the necrotic and tumorous tissues. Sixteen hepatocellular carcinoma cases were used for the evaluation of the CAV scheme. The total blood volume distribution of the liver tissue, tumor, and necrosis was computed in these datasets. The blood volumes for the liver tissue, tumor, and necrosis had 0.250±0.129, 0.171±0.073, and 0.054±0.045 ml/sec, respectively. The CAV scheme was shown to be potentially useful for efficient and accurate longitudinal measurement of liver tumor burdens in hepatic CT images.
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References
Vauthey, J.N., Dixon, E., Abdalla, E.K., Helton, W.S., Pawlik, T.M., Taouli, B., Brouquet, A., Adams, R.B.: Pretreatment assessment of hepatocellular carcinoma: expert consensus statement. HPB (Oxford) 12, 289–299 (2010)
Pandharipande, P.V., Krinsky, G.A., Rusinek, H., Lee, V.S.: Perfusion imaging of the liver: current challenges and future goals. Radiology 234, 661–673 (2005)
Ibanez, Schroeder, Ng, Cates, The ITK Software Guide. Kitware Inc. (2005)
Materne, R., Van Beers, B.E., Smith, A.M., Leconte, I., Jamart, J., Dehoux, J.P., Keyeux, A., Horsmans, Y.: Non-invasive quantification of liver perfusion with dynamic computed tomography and a dual-input one-compartmental model. Clin. Sci. (Lond) 99, 517–525 (2000)
Axel, L.: Tissue mean transit time from dynamic computed tomography by a simple deconvolution technique. Invest. Radiol. 18, 94–99 (1983)
Cai, W., Holalkere, N., Harris, G., Sahani, D., Yoshida, H.: Dynamic-threshold level set method for volumetry of porcine kidney in CT images: in-vivo and ex-vivo assessment of the accuracy of volume measurement. Acad. Radiol. 14, 890–896 (2007)
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Lee, JG., Cai, W., Singh, A., Yoshida, H. (2011). Estimation of Necrosis Volumes in Focal Liver Lesions Based on Multi-phase Hepatic CT Images. In: Yoshida, H., Cai, W. (eds) Virtual Colonoscopy and Abdominal Imaging. Computational Challenges and Clinical Opportunities. ABD-MICCAI 2010. Lecture Notes in Computer Science, vol 6668. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25719-3_9
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DOI: https://doi.org/10.1007/978-3-642-25719-3_9
Publisher Name: Springer, Berlin, Heidelberg
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