Skip to main content

Repair after Acute Lung Injury: Molecular Mechanisms and Therapeutic Opportunities

  • Chapter
  • 2248 Accesses

Part of the book series: Annual Update in Intensive Care and Emergency Medicine ((AUICEM,volume 2012))

Abstract

Acute lung injury (ALI) is a clinical syndrome characterized by impairment in gas exchange and/or lung mechanics that leads to hypoxemia and increased work of breathing (WOB). When respiratory failure occurs, most patients require mechanical ventilation. This clinical scenario is related to high morbidity and mortality rates.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ventrice EA, Marti-Sistac O, Gonzalvo R, Villagra A, Lopez-Aguilar J, Blanch L (2007) [Molecular and biophysical mechanisms and modulation of ventilator-induced lung injury]. Med Intensiva 31: 73–82

    Article  PubMed  CAS  Google Scholar 

  2. Bianchi ME (2007) DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 81: 1–5

    Article  PubMed  CAS  Google Scholar 

  3. de Carvalho ME, Dolhnikoff M, Meireles SI, Reis LF, Martins MA, Deheinzelin D (2007) Effects of overinflation on procollagen type III expression in experimental acute lung injury. Crit Care 11: R23

    Article  PubMed  Google Scholar 

  4. Armstrong L, Thickett DR, Mansell JP, et al (1999) Changes in collagen turnover in early acute respiratory distress syndrome. Am J Respir Crit Care Med 160: 1910–1915

    Article  PubMed  CAS  Google Scholar 

  5. Berthiaume Y, Matthay MA (2007) Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol 159: 350–359

    Article  PubMed  CAS  Google Scholar 

  6. Bhatia M, Moochhala S (2004) Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 202: 145–156

    Article  PubMed  CAS  Google Scholar 

  7. Kubo H (2011) Molecular basis of lung tissue regeneration. Gen Thorac Cardiovasc Surg 59: 231–244

    Article  PubMed  Google Scholar 

  8. Lindsay CD (2011) Novel therapeutic strategies for acute lung injury induced by lung damaging agents: the potential role of growth factors as treatment options. Hum Exp Toxicol 30: 701–724

    Article  PubMed  CAS  Google Scholar 

  9. Davey A, McAuley DF, O’Kane CM (2011) Matrix metalloproteinases in acute lung Injury: mediators of injury and drivers of repair. Eur Respir J 38: 959–970

    Article  PubMed  CAS  Google Scholar 

  10. Nin N, Lorente JA, de Paula M, et al (2008) Rats surviving injurious mechanical ventilation show reversible pulmonary, vascular and inflammatory changes. Intensive Care Med 34: 948–956

    Article  PubMed  CAS  Google Scholar 

  11. Gonzalez-Lopez A, Astudillo A, Garcia-Prieto E, et al (2011) Inflammation and matrix remodeling during repair of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 301: L500–509

    Article  PubMed  CAS  Google Scholar 

  12. Abraham E (2003) Neutrophils and acute lung injury. Crit Care Med 31: S195–199

    Article  PubMed  Google Scholar 

  13. Korpos E, Wu C, Sorokin L (2009) Multiple roles of the extracellular matrix in inflammation. Curr Pharm Des 15: 1349–1357

    Article  PubMed  CAS  Google Scholar 

  14. Lin M, Jackson P, Tester AM, et al (2008) Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro. Am J Pathol 173: 144–153

    Article  PubMed  CAS  Google Scholar 

  15. Van Lint P, Libert C (2007) Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. J Leukoc Biol 82: 1375–1381

    Article  PubMed  Google Scholar 

  16. Harty MW, Muratore CS, Papa EF, et al (2010) Neutrophil depletion blocks early collagen degradation in repairing cholestatic rat livers. Am J Pathol 176: 1271–1281

    Article  PubMed  CAS  Google Scholar 

  17. Parks WC (2003) Matrix metalloproteinases in lung repair. Eur Respir J Suppl 44:36s–38s

    Article  PubMed  CAS  Google Scholar 

  18. O’Kane CM, McKeown SW, Perkins GD, et al (2009) Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome. Crit Care Med 37: 2242–2249

    Article  CAS  Google Scholar 

  19. Albaiceta GM, Gutierrez-Fernandez A, Parra D, et al (2008) Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 294: L535–543

    Article  PubMed  CAS  Google Scholar 

  20. Nerusu KC, Warner RL, Bhagavathula N, McClintock SD, Johnson KJ, Varani J (2007) Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury. Exp Mol Pathol 83: 169–176

    Article  PubMed  CAS  Google Scholar 

  21. Yamashita CM, Dolgonos L, Zemans RL, et al (2011) Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol 179: 1733–1745

    Article  PubMed  CAS  Google Scholar 

  22. Albaiceta GM, Gutierrez-Fernandez A, Garcia-Prieto E, et al (2010) Absence or inhibition of matrix metalloproteinase-8 decreases ventilator-induced lung injury. Am J Respir Cell Mol Biol 43: 555–563

    Article  PubMed  CAS  Google Scholar 

  23. Garcia-Prieto E, Gonzalez-Lopez A, Cabrera S, et al (2010) Resistance to bleomycininduced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10. PLoS One 5:e13242

    Article  PubMed  CAS  Google Scholar 

  24. Quintero PA, Knolle MD, Cala LF, Zhuang Y, Owen CA (2010) Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice. J Immunol 184: 1575–1588

    Article  PubMed  CAS  Google Scholar 

  25. Gueders MM, Balbin M, Rocks N, et al (2005) Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol 175: 2589–2597

    PubMed  CAS  Google Scholar 

  26. Chesnutt AN, Matthay MA, Tibayan FA, Clark JG (1997) Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance. Am J Respir Crit Care Med 156: 840–845

    Article  PubMed  CAS  Google Scholar 

  27. Quesnel C, Nardelli L, Piednoir P, et al (2010) Alveolar fibroblasts in acute lung injury: biological behaviour and clinical relevance. Eur Respir J 35: 1312–1321

    Article  PubMed  CAS  Google Scholar 

  28. Yoon HK, Cho HY, Kleeberger SR (2007) Protective role of matrix metalloproteinase-9 in ozone-induced airway inflammation. Environ Health Perspect 115: 1557–1563

    Article  PubMed  CAS  Google Scholar 

  29. Verghese GM, McCormick-Shannon K, Mason RJ, Matthay MA (1998) Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance. Am J Respir Crit Care Med 158: 386–394

    Article  PubMed  CAS  Google Scholar 

  30. Rogel MR, Soni PN, Troken JR, Sitikov A, Trejo HE, Ridge KM (2011) Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells. FASEB J (in press)

    Google Scholar 

  31. Losa D, Chanson M, Crespin S (2011) Connexins as therapeutic targets in lung disease. Expert Opin Ther Targets 15: 989–1002

    Article  PubMed  CAS  Google Scholar 

  32. Vadivel A, Abozaid S, van Haaften T, et al (2010) Adrenomedullin promotes lung angiogenesis, alveolar development, and repair. Am J Respir Cell Mol Biol 43: 152–160

    Article  PubMed  CAS  Google Scholar 

  33. Liu Y, Sadikot RT, Adami GR, et al (2011) FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa. J Exp Med 208: 1473–1484

    Article  PubMed  CAS  Google Scholar 

  34. Lee JM, Kwon HJ, Bae SC, Jung HS (2010) Lung tissue regeneration after induced injury in Runx3 KO mice. Cell Tissue Res 341: 465–470

    Article  PubMed  CAS  Google Scholar 

  35. Plataki M, Lee YD, Rasmussen DL, Hubmayr RD (2011) Poloxamer 188 facilitates the repair of alveolus resident cells in ventilator injured lungs. Am J Respir Crit Care Med 184: 939–947

    Article  PubMed  CAS  Google Scholar 

  36. Giangreco A, Arwert EN, Rosewell IR, Snyder J, Watt FM, Stripp BR (2009) Stem cells are dispensable for lung homeostasis but restore airways after injury. Proc Natl Acad Sci USA 106: 9286–9291

    Article  PubMed  CAS  Google Scholar 

  37. Yang KY, Shih HC, How CK, et al (2011) IV delivery of induced pluripotent stem cells attenuates endotoxin-induced acute lung injury in mice. Chest 140: 1243–1253

    Article  PubMed  CAS  Google Scholar 

  38. Curley GF, Contreras M, Higgins BD, O’Toole DP, Laffey JG (2011) The role of mesenchymal stem cells during repair from ventilator induced lung injury. J Respir Crit Care Med (in press)

    Google Scholar 

  39. Plopper CG, St George JA, Read LC, et al (1992) Acceleration of alveolar type II cell differentiation in fetal rhesus monkey lung by administration of EGF. Am J Physiol 262: L313–321

    PubMed  CAS  Google Scholar 

  40. Harada C, Kawaguchi T, Ogata-Suetsugu S, et al (2011) EGFR tyrosine kinase inhibition worsens acute lung injury in mice with repairing airway epithelium. Am J Respir Crit Care Med 183: 743–751

    Article  PubMed  CAS  Google Scholar 

  41. Panoskaltsis-Mortari A, Ingbar DH, Jung P, et al (2000) KGF pretreatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMT. Am J Physiol Lung Cell Mol Physiol 278: L988–999

    PubMed  CAS  Google Scholar 

  42. Dohi M, Hasegawa T, Yamamoto K, Marshall BC (2000) Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis. Am J Respir Crit Care Med 162: 2302–2307

    Article  PubMed  CAS  Google Scholar 

  43. Medford AR, Millar AB (2006) Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm? Thorax 61: 621–626

    Article  PubMed  CAS  Google Scholar 

  44. Perkins GD, McAuley DF, Thickett DR, Gao F (2006) The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial. Am J Respir Crit Care Med 173: 281–287

    Article  PubMed  CAS  Google Scholar 

  45. Perkins GD, Gao F, Thickett DR (2008) In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury. Thorax 63: 215–220

    Article  PubMed  CAS  Google Scholar 

  46. Matthay MA, Brower RG, Carson S, et al (2011) Randomized, placebo-controlled clinical trial of an aerosolized beta-2 agonist for treatment of acute lung injury. Am J Respir Crit Care Med 184: 561–568

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

González-López, A., Albaiceta, G.M. (2012). Repair after Acute Lung Injury: Molecular Mechanisms and Therapeutic Opportunities. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2012. Annual Update in Intensive Care and Emergency Medicine, vol 2012. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25716-2_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-25716-2_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-25715-5

  • Online ISBN: 978-3-642-25716-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics