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Biological Applications of Surface Plasmon Resonance Imaging

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Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 10))

Abstract

This chapter will deal with versatile biochips. The presented biochips are prepared by the microarray functionalization of gold surface from millimetric to micrometric scale via different electrochemical approaches. Interactions occurring on these functionalized surfaces are monitored using surface plasmon resonance imaging approaches. Different size of spots including hyphenated techniques will be used to study biological interactions from molecular (i.e., DNA, proteins (toxins), and sugars) to complex objects such as living cells. Applications of this approach will be illustrated by examples from different biological fields including DNA hybridization studies, antibody screening in patients’ samples, study of oligosaccharides–proteins interactions, and lymphocytes characterization and sorting. For each topic, optimized chemistry and optical developments will be specified.

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Correspondence to T. Livache .

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© 2012 Springer-Verlag Berlin Heidelberg

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Leroy, L., Maillart, E., Livache, T. (2012). Biological Applications of Surface Plasmon Resonance Imaging. In: Fritzsche, W., Popp, J. (eds) Optical Nano- and Microsystems for Bioanalytics. Springer Series on Chemical Sensors and Biosensors, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25498-7_7

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