Abstract
The aim of the present study is to investigate the changes of gastrointestinal (GI) hormones in reserpine-treated rat. Reserpine (0.5 mg/kg body weight) was injected once per day for continuous 14 days. The histological changes of GI were observed and GI hormones variation was measured. The results showed that comparing with the control group, the reserpine-treated rats had obvious damages. In the GI damaged duodenum mRNA and protein content of gastrin (GAS), cholecystokinin (CCK), vasoactive intestinal polypeptide (VIP) were significantly decreased and somatostatin (SS) protein content were significantly increased comparing the control group. In the gastric antrum of reserpine-treated rats, mRNA and protein content of GAS increased significantly while those of CCK were significantly decreased comparing the control group. These results suggest that the GI hormones changes were associated with gastro and small intestine damage in reserpine-treated rats.
The work was partially supported by grants from National Natural Science Foundation of China (No. 30771591), National Eleven-five Technological Supported Plan of China (No. 2008BADB4B01; 2008BADB4B07), Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality.
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Guo, K. et al. (2012). Reserpine Caused Gastrointestinal Damages and Hormonal Changes in Rats. In: Wu, Y. (eds) Software Engineering and Knowledge Engineering: Theory and Practice. Advances in Intelligent and Soft Computing, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25349-2_6
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DOI: https://doi.org/10.1007/978-3-642-25349-2_6
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