Abstract
The combination of the study of embryonic development with a sophisticated genetic technology has led to the discovery of the molecular cascades that take place between DNA and the formation of an adult organism.
It has been known for over 100 years that the antennae of an insect can be transformed into a foot, and legs can be modified into wings, but these genetic events remained curiosities.
The discovery of homeobox genes, that determine the body plan of an animal and of a plant, changed radically this situation. Eight-legged and four-winged flies were produced and eyes were formed on wings and wings on eyes. Other experiments revealed the great importance of eye genes in development indicating the primary role of the eye in shaping body construction.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Bachiller D et al (1994) Conservation of a functional hierarchy between mammalian and insect Hox/Hom genes. EMBO J 13:1930–41
Bateson W (1894) Materials for the study of variation, treated with special regard to discontinuities in the origin of species. Macmillan, New York
Bender W (2008) MicroRNAs in the Drosophila bithorax complex. Genes Dev 22:14–19
Bender W et al (1983) Molecular genetics of the bithorax complex in Drosophila melanogaster. Science 221:23–29
Boncinelli E et al (1988) Organization of human homeobox genes. Hum Reprod 3:880–886
Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71–94
Callaerts P et al (1997) Pax-6 in development and evolution. Annu Rev Neurosci 20:483–532
Callaerts P et al (2002) HOX genes in the sepiolid squid Euprymna scolopes: implications for the evolution of complex body plans. Proc Natl Acad Sci USA 99:2088–2093
Carrasco AE et al (1984) Cloning of an X. laevis gene expressed during early embryogenesis that codes for a peptide region homologous to Drosophila homeotic genes. Cell 37:409–414
Garcia-Fernandez J, Holland PW (1994) Archetypal organization of the amphioxus Hox gene cluster. Nature 370:563–566
Gehring WJ (1998) Master control genes in development and evolution: the homeobox story. Yale University Press, New Haven
Gehring WJ et al (2009) Evolution of the Hox gene complex from an evolutionary ground state. Curr Top Dev Biol 88:35–61
Gilbert SF (2000) Developmental biology. Sinauer Associates Publ., Sunderland
Hafen E et al (1984) Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila. Nature 307:287–289
Halder GP et al (1995) Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267:1788–1792
Hiromi Y, Gehring WJ (1987) Regulation and function of the Drosophila gene fushi tarazu. Cell 50:963–974
Holley SA (2007) The genetics and embryology of zebrafish metamerism. Dev Dyn 236:1422–1449
Hood L (2002) After the genome. Where should we go? In: Yudell M, DeSalle R (eds) The genomic revolution. Joseph Henry Press, Washington, DC, pp 64–73
Jiang T-X et al (1999) Self organization of periodic patterns by dissociated feather mesenchymal cells and the regulation of size, number and spacing of primordia. Development 126:4997–5009
Kim K et al (2010) Epigenetic memory in induced pluripotent stem cells. Nature 467:285–290
Lawrence PA (1992) The making of a fly. The genetics of animal design. Blackwell Scientific Publications, Oxford
Lewis EB (1978) A gene complex controlling segmentation in Drosophila. Nature 276:565–570
Lewis EB (1992) Clusters of master control genes regulate the development of higher organisms. J Am Med Assoc 267:1524–1531
Lu P et al (1996) Identification of a meristem L1 layer-specific gene in Arabidopsis that is expressed during embryonic pattern formation and defines a new class of homeobox genes. Plant Cell 8:2155–2168
McGinnis W et al (1984a) A conserved DNA sequence in homeotic genes of the Drosophila Antennapedia and bithorax complex. Nature 308:428–433
McGinnis W et al (1984b) Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. Cell 38:675–680
McGrew MJ et al (1998) The lunatic Fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos. Curr Biol 8:979–982
Müntzing A (1961) Genetic research. A survey of methods and main results. LTs Förlag, Stockholm
Nüsslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287:795–801
Quiring R et al (1994) Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans. Science 265:785–789
Rivera-Pomar R, Jäckle H (1996) From gradients to stripes in Drosophila: filling in the gaps. Trends Genet 12:478–483
Salser S, Kenyon C (1994) Patterning C. elegans: homeotic cluster genes, cell fates and cell migrations. Trends Genet 10:159–164
Schneuwly S et al (1987) Redesigning the body plan of Drosophila by ectopic expression of the homoeotic gene Antennapedia. Nature 325:816–818
Scott M, Weiner A (1984) Structural relationships among genes that control development: sequence homology between Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila. Proc Natl Acad Sci USA 81:4115–4119
Shepherd JCW et al (1984) Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins. Nature 310:70–71
Ting-Berreth SA, Chuong C-M (1996) Sonic hedgehog in feather morphogenesis: induction of mesenchymal condensation and association with cell death. Dev Dyn 207:157–170
Varjosalo M, Taipale J (2008) Hedgehog: functions and mechanisms. Genes Dev 22:2454–2472
Werner T et al (2010) Generation of a novel wing colour pattern by the Wingless morphogen. Nature 464:1143–1149
Wood WB et al (1988) The nematode “Caenorhabditis elegans”. Cold Spring Harbor Laboratory, New York
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Lima-de-Faria, A. (2012). How to Redesign the Body Pattern of an Organism. In: Molecular Geometry of Body Pattern in Birds. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25301-0_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-25301-0_7
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-25300-3
Online ISBN: 978-3-642-25301-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)