Abstract
Dynamic nuclear polarization (DNP) is a commonly applied NMR hyperpolarization technique, which is based on the polarization transfer from electron spins to nuclear spins. While DNP allows a significant enhancement of NMR signals by several orders of magnitude, major drawbacks of the method include enhanced nuclear relaxation times due to the presence of unpaired electrons and the toxicity of radicals, which is the limiting factor for in vivo applications in magnetic resonance imaging. Thus, an efficient separation of the polarization agent is a key requirement for possible applications in medicine. In this chapter, the application of spin-labeled thermoresponsive hydrogels as polarizing agents for dynamic nuclear polarization is explored.
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References
Bargon J, Fischer H, Johnsen U (1967) Z Naturforsch A 22:1551–1555
Bargon J, Fischer H (1967) Z Naturforsch A 22:1556–1562
Hore PJ, Broadhurst RW (1993) Prog Nucl Magn Reson Spectrosc 25:345–402
Matysik J, Diller A, Roy E, Alia A (2009) Photosynth Res 102:427–435
Bowers CR, Weitekamp DP (1986) Phys Rev Lett 57:2645–2648
Bowers CR, Weitekamp DP (1987) J Am Chem Soc 109:5541–5542
Eisenschmid TC, Kirss RU, Deutsch PP, Hommeltoft SI, Eisenberg R, Bargon J, Lawler RG, Balch AL (1987) J Am Chem Soc 109:8089–8091
Pravica MG, Weitekamp DP (1988) Chem Phys Lett 145:255–258
Goodson BM (2002) J Magn Reson 155:157–216
Overhauser AW (1953) Phys Rev 92:411–415
Carver TR, Slichter CP (1953) Phys Rev 92:212–213
Carver TR, Slichter CP (1956) Phys Rev 102:975–980
Becerra LR, Gerfen GJ, Temkin RJ, Singel DJ, Griffin RG (1993) Phys Rev Lett 71:3561–3564
Bowen S, Hilty C (2008) Angew Chem Int Ed 47:5235–5237
Bajaj VS, Mak-Jurkauskas ML, Belenky M, Herzfeld J, Griffin RG (2009) Proc Nat Acad Sci USA 106:9244–9249
Day SE, Kettunen MI, Gallagher FA, Hu DE, Lerche M, Wolber J, Golman K, Ardenkjaer-Larsen JH, Brindle KM (2007) Nat Med 13:1521
Golman K, in’t Zandt R, Lerche M, Pehrson R, Ardenkjaer-Larsen JH (2006) Cancer Res 66:10855–10860
Gallagher FA, Kettunen MI, Day SE, Hu DE, Ardenkjaer-Larsen JH, in’t Zandt R, Jensen PR, Karlsson M, Golman K, Lerche MH, Brindle KM (2008) Nature 453:940–943
Prisner T, Köckenberger W (2008) Appl Magn Reson 34:213–218
Sezer D, Gafurov M, Prandolini MJ, Denysenkov VP, Prisner TF (2009) Phys Chem Chem Phys 11:6638–6653
McCarney ER, Armstrong BD, Lingwood MD, Han S (2007) Proc Nat Acad Sci USA 104:1754–1759
McCarney ER, Armstrong BD, Kausik R, Han S (2008) Langmuir 24:10062–10072
Armstrong BD, Lingwood MD, McCarney ER, Brown ER, Blümler P, Han S (2008) J Magn Reson 191:273–281
Münnemann K, Bauer C, Schmiedeskamp J, Spiess HW, Schreiber WG, Hinderberger D (2008) Appl Magn Reson 34:321–330
Song C, Hu K-N, Joo C-G, Swager TM, Griffin RG (2006) J Am Chem Soc 128:11385–11390
Maly T, Debelouchina GT, Bajaj VS, Hu K-N, Joo C-G, Mak-Jurkauskas ML, Sirigiri JR, van der Wel PCA, Herzfeld J, Temkin RJ, Griffin RG (2008) J Chem Phys 128:052211
Höfer P, Parigi G, Luchinat C, Carl P, Guthausen G, Reese M, Carlomagno T, Griesinger C, Bennati M (2008) J Am Chem Soc 130:3254–3255
Ardenkjaer-Larsen JH, Fridlund B, Gram A, Hansson G, Hansson L, Lerche MH, Servin R, Thaning M, Golman K (2003) Proc Nat Acad Sci USA 100:10158–10163
Comment A, Rentsch J, Kurdzesau F, Jannin S, Uffmann K, van Heeswijk RB, Hautle P, Konter JA, van den Brandt B, van der Klink JJ (2008) J Magn Reson 194:152–155
Gitti R, Wild C, Tsiao C, Zimmer K, Glass TE, Dorn HC (1988) J Am Chem Soc 110:2294–2296
McCarney ER, Han S (2008) J Magn Reson 190:307–315
Thaning M, Servin R (GE Healthcare, Inc.) Method of dynamic nuclear polarisation DNP, USPTO patent application 20080260649, applied on 12-1-2006, published on 10-23-2008
Hirotsu S, Hirokawa Y, Tanaka T (1987) J Chem Phys 87:1392–1395
Schild HG (1992) Prog Polym Sci 17:163–249
Hausser KH, Stehlik D (1968) Adv Magn Reson9 3:79–139
Nicholson I, Lurie DJ, Robb FJL (1994) J Magn Reson B 104:250–255
Benial AMF, Ichikawa K, Murugesan R, Yamada K, Utsumi H (2006) J Magn Reson 182:273–282
Bates RD, Drozdoski WS (1977) J Chem Phys 67:4038–4044
Robinson BH, Haas DA, Mailer C (1994) Science 263:490–493
Armstrong BD, Han S (2007) J Chem Phys 127:104508
Beines PW, Klosterkamp I, Menges B, Jonas U, Knoll W (2007) Langmuir 23:2231–2238
Gianneli M, Beines PW, Roskamp RF, Koynov K, Fytas G, Knoll W (2007) J Phys Chem C 111:13205–13211
Junk MJN, Jonas U, Hinderberger D (2008) Small 4:1485–1493
Cao Y, Zhu XX, Luo J, Liu H (2007) Macromolecules 40:6481–6488
Cao Y, Zhao N, Wu K, Zhu XX (2009) Langmuir 25:1699–1704
Atherton NM (1993) Principles of electron spin resonance. Ellis Horwood, New York
Han S, McCarney ER, Armstrong BD (2008) Appl Magn Reson 34:439–451
Wind RA, Duijvestijn MJ, van der Lugt C, Manenschijn A, Vriend J (1985) Prog Nucl Magn Reson Spectrosc 17:33–67
Abragam A, Goldman M (1978) Rep Prog Phys 41:395–467
Hu K-N, Yu H-h, Swager TM, Griffin RG (2004) J Am Chem Soc 126:10844–10845
Hu K-N, Song C, Yu H-h, Swager TM, Griffin RG (2008) J Chem Phys 128:052302
Shea KJ, Stoddard GJ, Shavelle DM, Wakui F, Choate RM (1990) Macromolecules 23:4497–4507
Toomey R, Freidank D, Rühe J (2004) Macromolecules 37:882–887
Dollmann BC, Junk MJN, Drechsler M, Spiess HW, Hinderberger D, Münnemann K (2010) Phys Chem Chem Phys 12:5879–5882
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Junk, M.J. (2012). Thermoresponsive Spin-Labeled Hydrogels as Separable DNP Polarizing Agents. In: Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy. Springer Theses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25135-1_6
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DOI: https://doi.org/10.1007/978-3-642-25135-1_6
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