Skip to main content

Abstract

Radiochemistry is integral to tracer development, not only to enable labelling of putative tracers for early pre-clinical evaluation, but also to bridge efforts in medicinal chemistry, biological evaluation, tracer selection, method development, and tracer production for early human studies. INM has historically relied on access to experimental radiotracers through national and international collaborations, and it has been a long-term strategic goal for the Institute to establish its own radiochemistry group in order to stay at the forefront of nuclear imaging.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.95
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 59.95
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  • Stone JM, Erlandsson K, Ã…rstad E, Squassante L, Teneggi V, Bressan RA, Krystal JH, Ell PJ, Pilowsky LS (2008). Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy: a [(123)I]CNS-1261 SPET study. Psychopharmacology 197(3), 401–408.

    Article  PubMed  CAS  Google Scholar 

  • Stone J.M., Erlandsson K., Ã…rstad E., Bressan R.A., Squassante L., Teneggi V., Ell P.J., Pilowsky L.S. (2006), Ketamine displaces the novel NMDA receptor SPET probe [123I]CNS-1261 in humans in vivo, Nuclear Medicine and Biology, 33(2), 239–43.

    Article  PubMed  CAS  Google Scholar 

  • Stone J.M., Ã…rstad E., Erlandsson K., Waterhouse R.N., Ell P.J., Pilowsky L.S. (2006), [123I]TPCNE – A novel SPET tracer for the sigma-1 receptor: First human studies and in vivo haloperidol challenge, SYNAPSE, 60(2); 109–107.

    Article  PubMed  CAS  Google Scholar 

  • Ã…rstad E., Gitto R., Chimirri A., Caruso R., Constanti A., Turton D., Hume S.P., Ahmad R., Pilowsky L.S., Luthra S.K (2006). Closing in on the AMPA receptor: Synthesis and evaluation of 2-acyl-1-(p-chlorophenyl)-6-methoxy-7-[11C]methoxy-1,2,3,4-tetrahydroisoquinoline as a potential PET tracer, Bioorganic & Medicinal Chemistry, 14 (14), 4712–4717.

    Article  Google Scholar 

  • Ã…rstad E, Wester HJ, Luthra SK, Pilowsky LS, Henriksen G (2006), Towards NR2B subtype selective PET tracers: Synthesis and Evaluation of styrene-, naphthyl and 4- trifluoromethoxyphenyl N-(2-[11-C] methoxybenzyl) amidine, Bioorganic & Medicinal Chemistry, 14(18), 6307–6313.

    Article  Google Scholar 

  • Schoultz BW, Hjornevik T, Willoch F, Marton J, Noda A, Murakami Y, Miyoshi S, Nishimura S, Ã…rstad E, Drzezga A, Matsunari I, Henriksen G (2010). Evaluation of the kappa-opioid receptor-selective tracer [(11)C]GR103545 in awake rhesus macaques. Eur J Nucl Med Mol Imaging. 37(6):1174–1180.

    Article  PubMed  CAS  Google Scholar 

  • Yan R., El-Emir E., Rajkumar V., Robson M., Jathoul A.P., Pedley R.B. and Ã…rstad E. One-pot Formation of a 125I-labeled Trifunctional Reagent for Multiscale Imaging with Optical and Nuclear Techniques. Angewandte Chemie Int Ed., 2011, 50, 6793–679

    Article  CAS  Google Scholar 

Download references

Author information

Consortia

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

University College NHS Foundation Trust and University College London. (2012). Radiochemistry and Pre-clinical First Steps. In: FESTSCHRIFT The Institute of Nuclear Medicine 50 Years. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25123-8_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-25123-8_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-24714-9

  • Online ISBN: 978-3-642-25123-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics