An Efficient Approach to Intensity Inhomogeneity Compensation Using c-Means Clustering Models
Intensity inhomogeneity or intensity non-uniformity (INU) is an undesired phenomenon that represents the main obstacle for magnetic resonance (MR) image segmentation and registration methods. Various techniques have been proposed to eliminate or compensate the INU, most of which are embedded into clustering algorithms, and they generally have difficulties when INU reaches high amplitudes. This study reformulates the design of c-means clustering based INU compensation techniques by identifying and separating those globally working computationally costly operations that can be applied to gray intensity levels instead of individual pixels. The theoretical assumptions are demonstrated using the fuzzy c-means algorithm, but the proposed modification is compatible with a various range of c-means clustering based techniques. Experiments using synthetic phantoms and real MR images indicate that the proposed approach produces practically the same segmentation accuracy as the conventional formulation, but 20-30 times faster.
Keywordsimage segmentation magnetic resonance imaging intensity inhomogeneity c-means clustering histogram
- 3.Derganc, J., Likar, B., Pernus̆, F.: Nonparametric segmentation of multispectral MR images incorporating spatial and intensity information. Progr. Biomed. Opt. Imag. 3(1), 391–400 (2002)Google Scholar
- 4.Internet Brain Segmentation Repository, http://www.cma.mgh.harvard.edu/ibsr
- 14.Vemuri, P., Kholmovski, E.G., Parker, D.L., Chapman, B.E.: Coil sensitivity estimation for optimal SNR reconstruction and intensity inhomogeneity correction in phased array MR imaging. In: Christensen, G.E., Sonka, M. (eds.) IPMI 2005. LNCS, vol. 3565, pp. 603–614. Springer, Heidelberg (2005)CrossRefGoogle Scholar
- 15.Vovk, U., Pernus̆, F., Likar, B.: MRI intensity inhomogeneity correction by combining intensity and spatial information. Phys. Med. Biol. 49(17), 4119–4133 (2004)Google Scholar
- 16.Vovk, U., Pernus̆, F., Likar, B.: A review of methods for correction of intensity inhomogeneity in MRI. IEEE Trans. Med. Imag. 26(3), 405–421 (2007)Google Scholar