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Peripheral Signals Modifying Food Reward

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Appetite Control

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 209))

Abstract

The pleasure derived from eating may feel like a simple emotion, but the decision to eat, and perhaps more importantly what to eat, involves central pathways linking energy homeostasis and reward and their regulation by metabolic and endocrine factors. Evidence is mounting that modulation of the hedonic aspects of energy balance is under the control of peripheral neuropeptides conventionally associated with homeostatic appetite control. Here, we describe the significance of reward in feeding, the neural substrates underlying the reward pathway and their modification by peptides released into the circulation from peripheral tissues.

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Abbreviations

α-MSH:

α-Melanocyte-stimulating hormone

AgRP:

Agouti-related peptide

Amy:

Amygdala

ARC:

Arcuate nucleus

CCK:

Cholecystokinin

DR:

Dorsal raphe

GHS-R1A:

Growth hormone secretagogue receptor 1A

GIP:

Gastric inhibitory polypeptide

GLP-1:

Glucagon-like peptide 1

JAK-STAT:

Janus kinase-signal transducer and activator of transcription

LDTg:

Laterodorsal tegmental area

LH:

Lateral hypothalamus

NAcc:

Nucleus accumbens

NPY:

Neuropeptide Y

NTS:

Nucleus tractus solitarius

ObRb:

Leptin (ob) receptor b

OLETF:

Otsuka Long-Evans Tokushima fatty

OXT:

Oxytocin

PBn:

Parabrachial nucleus

PFC:

Prefrontal cortex

PVN:

Paraventricular nucleus

PYY:

Peptide YY

SON:

Supraoptic nucleus

V1aR:

Vasopressin receptor 1a

VPall:

Ventral pallidum

VTA:

Ventral tegmental area

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Acknowledgements

Supported by the EU Seventh Framework programme under grant agreements FP7-KBBE-2009-245009 (NeuroFAST), FP7-HEALTH-2009–241592 (EurOCHIP) and FP7-KBBE-2010-266408 (Full4Health), The Swedish Medical Research Council (K2007-54X-20328–013), ALF Göteborg (SU7601), the Swedish Foundation for Strategic Research to Sahlgrenska Center for Cardiovascular and Metabolic Research (A305-188) and the Swedish Institute.

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  1. Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, Scotland, UK

    John R. W. Menzies & Gareth Leng

  2. Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

    Karolina P. Skibicka, Emil Egecioglu & Suzanne L. Dickson

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  1. John R. W. Menzies
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Correspondence to John R. W. Menzies .

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    Hans-Georg Joost

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Menzies, J.R.W., Skibicka, K.P., Egecioglu, E., Leng, G., Dickson, S.L. (2012). Peripheral Signals Modifying Food Reward. In: Joost, HG. (eds) Appetite Control. Handbook of Experimental Pharmacology, vol 209. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24716-3_6

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