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Appetite-Modifying Effects of Bombesin Receptor Subtype-3 Agonists

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Book cover Appetite Control

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 209))

Abstract

Studies on bombesin-like peptides (BLP) and their respective mammalian receptors (Bn-r) have demonstrated a significant biological impact on a broad array of physiological and pathophysiological conditions. Pharmacological experiments in vitro and in vivo as well as utilization of genetic rodent models of the gastrin-releasing peptide receptor (GRP-R/BB2-receptor), neuromedin B receptor (NMB-R/BB1-receptor), and the bombesin receptor subtype-3 (BRS-3/BB3-receptor) further delineated their role in health and disease. All three mammalian bombesin receptors have been shown to possess some role in the regulation of energy balance and appetite and satiety. Compelling experimental evidence has accumulated indicating that the orphan BRS-3 is an important regulator of body weight, energy expenditure, and glucose homeostasis. BRS-3 possesses no high affinity to the endogenous bombesin-like peptides (BLP) bombesin, GRP, and NMB, and its endogenous ligand remains unknown. Recently, the synthesis of novel, selective high-affinity BRS-3 agonists and antagonists has been accomplished and has demonstrated that BRS-3 regulates energy balance independent of other established pathways. Accordingly, the availability of new BRS-3 selective agonists and antagonists will facilitate further elucidation of its role in energy homeostasis and provides a potential approach for the pharmacological treatment of obesity.

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Authors and Affiliations

  1. Section of Gastroenterology, Boston University School of Medicine, Boston, MA, USA

    Ishita Deb Majumdar & H. Christian Weber

  2. Department of Medicine and Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 650 Albany Street, EBRC Room 515, Boston, MA, 02118, USA

    H. Christian Weber

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  1. Ishita Deb Majumdar
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  2. H. Christian Weber
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Correspondence to H. Christian Weber .

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  1. , Department of Pharmacology, German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, Nuthetal, 14558, Germany

    Hans-Georg Joost

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Majumdar, I.D., Weber, H.C. (2012). Appetite-Modifying Effects of Bombesin Receptor Subtype-3 Agonists. In: Joost, HG. (eds) Appetite Control. Handbook of Experimental Pharmacology, vol 209. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24716-3_19

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