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Role of CD36 in Oral and Postoral Sensing of Lipids

  • M. Chevrot
  • C. Martin
  • P. Passilly-Degrace
  • P. Besnard
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 209)

Abstract

Obesity and associated plethora of diseases constitute a major public health challenge worldwide. The conjunction of profound changes in our lifestyle and a thrifty genetic that evolved in an environment of food scarcity largely explains this epidemic situation. Food abundance promotes our specific appetite for the more palatable food generally rich in lipids. It is noteworthy that this attraction for fatty food is not specific to humans. Rats and mice also spontaneously prefer lipid-rich food in a free-choice situation. Detection of lipids in food requires the presence of specific sensors located in strategic places (e.g., oral cavity, small intestine, brain) whose activation results in a modulation of the eating behavior. Recent data strongly suggest that the glycoprotein CD36 plays a significant role in this sensing system.

Keywords

Central nervous system Dietary lipids Eating behavior Endocannabinoids Health Lipid receptors Obesity risk Sense of taste Small intestine 

Abbreviations

BBB

Blood–brain barrier

BMI

Body mass index

CART

Cocaine-amphetamine-related peptide

CCK

Cholecystokinin

FATP

Fatty acid transport proteins

GLP-1

Glucagon-like peptide-1

GPCR

G protein-coupled receptors

HBMEC

Human brain microvessel endothelial cells

LCFA

Long-chain fatty acid

LPL

Lipoprotein lipase

MAPK

Mitogen-activated protein kinase

MTP

Microsomal triglyceride transfer protein

NPY

Neuropeptide Y

NST

Nucleus of solitary tract

OEA

Oleoylethanolamine

PTK

Protein tyrosine kinase

TBC

Taste bud cells

TG

Triglyceride

T1R

Taste 1 receptors

SSO

Sulfo-N-succinimidyl oleate ester

Notes

Acknowledgements

This work was supported by the French Research Agency (ANR, sensoFAT project to P.B.) and the Burgundy Council and the Centre National Interprofessionnel de l’Economie Laitière (CNIEL) through the HumanFATaste program (to P.B.).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • M. Chevrot
    • 1
  • C. Martin
    • 1
  • P. Passilly-Degrace
    • 1
  • P. Besnard
    • 1
  1. 1.Physiologie de la NutritionUMR U866 INSERM/Université de BourgogneDijonFrance

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