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Zusammenfassung

Am 18. Gestationstag, bei einer Länge des Embryos von etwa 2,5 mm, verdickt sich das distale Ende des Vorderdarms und beginnt, sich als Leberknospe vorzuwölben (Leberdivertikel; Tab. 13.1).

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Literatur

Literatur zu Abschn. 13.1

  • Amenta PS, Harrison D (1997) Expression and potential role of the extracellular matrix in hepatic ontogenesis: a review. Microscop Res Techn 39: 372–386

    Article  CAS  Google Scholar 

  • Colon AR (1990) Textbook of pediatric hepatology. Year Book Med Pub, Chicago

    Google Scholar 

  • Crawford JM (2002) Development of the intrahepatic biliary tree. Semin Liver Dis 22: 213–226

    Article  PubMed  Google Scholar 

  • Karpen SJ, Suchy FJ (2001) Structural and functional development of the liver. In: Suchy FJ, Sokol RJ, Balistreri WF (eds) Liver disease in children. Lippincott Williams & Wilkins, Philadelphia, pp 3–21

    Google Scholar 

  • Kaufman SS (1998) Organogenesis and histologic development of the liver. In: Polin RA, Fox WW (eds) Fetal and neonatal physiology. Saunders, Philadelphia, pp 1433–1441

    Google Scholar 

  • MacSween RNM, Desmet VJ, Roskams T, Scothorne RJ (2002) Developmental anatomy and normal structure. In: MacSween RNM, Ishak KG, Burt AD et al. (eds) Pathology of the liver. Churchill Livingstone, London, pp 1–66

    Google Scholar 

  • Malarkey DE, Johnson K, Ryan L, Boorman G, Maronpot RR (2005) New insights into functional aspects of liver morphology. Toxicol Pathol 33: 27–34

    Article  PubMed  CAS  Google Scholar 

  • McLin VA, Yazigi N (2006) Developmental anatomy and physiology of the liver and bile ducts. In: Wyllie R, Hyams JS (eds) Pediatric gastrointestinal and liver disease, 3rd edn. Saunders Elsevier, Philadelphia, pp 841–849

    Chapter  Google Scholar 

  • Nakanuma Y, Hoso M, Sanzen T, Sasaki M (1997) Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply. Microsc Res Tech 38: 552–570

    Article  PubMed  CAS  Google Scholar 

  • Peters RL (1983) Early development of the liver: a review. In: Fisher MM, Roy CC (eds) Pediatric liver disease. Plenum Press, New York, pp 1–15

    Chapter  Google Scholar 

  • Sergi C, Adam S, Kahl P, Otto HF (2000) The remodelling of the primitive human biliary system. Early Hum Dev 58: 167–178

    Article  PubMed  CAS  Google Scholar 

  • Shankle WR, Landing BH, Gregg J (1983) Normal organ weights of infants and children: graphs of values by age, with confidence intervals. Pediatr Pathol 1: 399–408

    Article  PubMed  CAS  Google Scholar 

  • Shiojiri N (1984) The origin of the intrahepatic bile duct cells in the mouse. J Embryol Exp Morphol 79: 25–39

    PubMed  CAS  Google Scholar 

  • Wuestefeld T, Zaret KS (2007) Liver development: from endoderm to hepatocyte. In: Suchy J, Sokol RJ, Balistreri WF (eds) Liver disease in children, 3rd edn. Cambridge University Press, Cambridge, pp 3–13

    Chapter  Google Scholar 

  • Zakim D, Boyer TD (2003) Hepatology. A textbook of liver disease. Saunders, Philadelphia

    Google Scholar 

Literatur zu Abschn. 13.2

  • Arias IM, Popper H, Schachter D, Shafritz DA (1982) The liver, biology and pathobiology. Raven Press, New York

    Google Scholar 

  • Fahey JT (1994) Developmental aspects of hepatic blood flow. In: Suchy FJ (ed) Liver disease in children. Mosby, St Louis, pp 31–38

    Google Scholar 

  • Laut WW, Greenway (1987) Conceptual review of the hepatic vascular bed. Hepatology 7: 952–963

    Article  Google Scholar 

  • Rudolph CD, Rudolph AM (1998) Fetal and postnatal hepatic vasculature and blood flow. In: Polin RA, Fox WW (eds) Fetal and neonatal physiology. Saunders, Philadelphia, pp 1442–1449

    Google Scholar 

  • Taylor IM (1983) Developmental aspects of the hepatic circulation. In: Fisher MM, Roy CC (eds) Pediatric liver disease. Plenum Press, New York, pp 17–42

    Chapter  Google Scholar 

Literatur zu Abschn. 13.3

  • Battaglia FC, Thureen PJ (1997) Nutrition of the fetus and premature infant. Nutrition 13: 903–906

    Article  PubMed  CAS  Google Scholar 

  • Battaglia FC, Thureen PJ (1998) Nutrition of the fetus and the premature infant. Diabetes Care 21: B70–B74

    PubMed  Google Scholar 

  • Berghaus TM, Demmelmair H, Koletzko B (1998) Fatty acid composition of lipid classes in maternal and cord plasma at birth. Eur J Pediatr 157: 763–768

    Article  PubMed  CAS  Google Scholar 

  • Greengard O (1977) Enzymatic differentiation of human liver: comparison with the rat model. Pediatr Res 11: 669–676

    Article  PubMed  CAS  Google Scholar 

  • Hay WW Jr (1998) Nutrient and metabolic needs of the fetus and very small infant: a comparative approach. Biochem Soc Trans 26: 75–78

    PubMed  CAS  Google Scholar 

  • Koletzko B, Demmelmair H, Socha P (1998) Nutritional support of infants and children: supply and metabolism of lipids. Clin Gastroenterol 12: 671–696

    CAS  Google Scholar 

  • MacSween RNM, Ishak KG, Burt AD et al. (2002) Pathology of the liver. Churchill Livingstone, London

    Google Scholar 

  • Narkewicz MR (1994) Hepatic energy metabolism in the fetus and neonate. In: Suchy FJ (ed) Liver disease in children. Mosby, St Louis, pp 39–56

    Google Scholar 

  • Suchy FJ (2007) Functional development of the liver. In: Suchy J, Sokol RJ, Balistreri WF (eds) Liver disease in children, 3rd edn. Cambridge University Press, Cambridge, pp 4–27

    Chapter  Google Scholar 

  • Uauy R, Treen M, Hoffman DR (1989) Essential fatty acid metabolism and requirements during development. Semin Perinatol 13: 118–130

    PubMed  CAS  Google Scholar 

  • Zlotkin SH, Anderson GH (1982) The development of cystathionase activity during the first year of life. Pediatr Res 16: 65–68

    Article  PubMed  CAS  Google Scholar 

Literatur zu Abschn. 13.4

  • Argao EA, Balistreri WF (1993) Bile acid physiology and alterations in the enterohepatic circulation. In: Willie R, Hyams JS (eds) Pediatric gastrointestinal disease. Saunders, Philadelphia, pp 31–45

    Google Scholar 

  • Björkhem I, Boberg KM (1995) Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease. McGraw-Hill, New York, pp 2073–2099

    Google Scholar 

  • Bucuvalas JC (1998) Bile acid metabolism during development. In: Polin RA, Fox WW (eds) Fetal and neonatal physiology. Saunders, Philadelphia, pp 1450–1456

    Google Scholar 

  • Burt AD, Day CP (2002) Pathophysiology of the liver. In: MacSween RNM, Ishak KG, Burt AD et al. (eds) Pathology of the liver. Churchill Livingstone, London, pp 67–105

    Google Scholar 

  • Chen HL, Liu YJ et al. (2005) Developmental expression of canalicular transporter genes in human liver. J Hepatol 43: 472–477

    Article  PubMed  CAS  Google Scholar 

  • Chuang E, Haber BA (1998) Bile secretion and its control in the mature and immature organism. In: Polin RA, Fox WW (eds) Fetal and neonatal physiology. Saunders, Philadelphia, pp 1457–1471

    Google Scholar 

  • Colombo C, Zuliani G, Ronchi M, Breidenstein J, Setchell KD (1987) Biliary bile acid composition of the human fetus in early gestation. Pediatr Res 21: 197–200

    Article  PubMed  CAS  Google Scholar 

  • Erlinger S (1987) Physiology of bile secretion and enterohepatic circulation. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven Press, New York, pp 1557–1580

    Google Scholar 

  • Gerok W (1992) Physiology of bile formation. In: Lentze MJ, Reichen J (eds) Paediatric cholestasis. Novel approaches to treatment. Kluwer, Dordrecht, pp 3–26

    Google Scholar 

  • Karpen SJ (2007) Mechanisms of bile formation and cholestasis. In: Suchy J, Sokol RJ, Balistreri WF (eds) Liver disease in children, 3rd edn. Cambridge University Press, Cambridge, pp 28–34

    Chapter  Google Scholar 

  • Lecureur V, Courtois A, Payen L et al. (2000) Expression and regulation of hepatic drug and bile acid transporters. Toxicology 153: 203–219

    Article  PubMed  CAS  Google Scholar 

  • Löffler G, Petrides PE (1997) Biochemie und Pathobiochemie. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Setchell KDR, O’Connell NC (2007) Disorders of bile acid synthesis and metabolism: a metabolic basis for liver disease. In: Suchy FJ, Sokol RJ, Balisteri WF (eds) Liver disease in children, 3rd edn. Cambridge University Press, Cambridge, pp 736

    Chapter  Google Scholar 

  • Suchy FJ (2007) Functional development of the liver. In: Suchy J, Sokol RJ, Balistreri WF (eds) Liver disease in children, 3rd edn. Cambridge University Press, Cambridge, pp 4–27

    Chapter  Google Scholar 

  • Trauner M, Wagner M, Fickert P, Zollner G (2005) Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis. J Clin Gastroemterol 39 (Suppl 2): S111–S124

    Article  Google Scholar 

  • Vonk RJ, Kuipers F, Smit MJ et al. (1992) Bile acid metabolism in children. In: Lentze MJ, Reichen J (eds) Paediatric cholestasis. Novel approaches to treatment. Kluwer, Dordrecht, pp 27–37

    Google Scholar 

  • Wagner M, Trauner M (2005) Transcriptional regulation of hepatobiliary transport systems in health and disease: implications for a rationale approach to the treatment of intrahepatic cholestasis. Ann Hepatol 4: 77–99

    PubMed  CAS  Google Scholar 

  • Watkins JB (1983) Developmental aspects of bile acid metabolism and hepatic function. In: Fisher MM, Roy CC (eds) Pediatric liver disease. Plenum Press, New York, pp 43–53

    Chapter  Google Scholar 

  • Zakim D, Boyer TD (1982/2003) Hepatology. A textbook of liver disease. Saunders, Philadelphia

    Google Scholar 

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Deutsch, J. (2013). Embryologie und Physiologie der Leber. In: Rodeck, B., Zimmer, KP. (eds) Pädiatrische Gastroenterologie, Hepatologie und Ernährung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24710-1_13

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  • DOI: https://doi.org/10.1007/978-3-642-24710-1_13

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