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Synthesis of Heck Coupling Partner for the Preparation of Heteroaromatic Lipoxin A4 Analogues

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Heteroaromatic Lipoxin A4 Analogues

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Abstract

Our research group recently developed a short and efficient synthetic route for the preparation of novel stable benzene-containing Lipoxin A4 and Lipoxin B4 analogues. One of the key synthetic steps relies on the construction of a trans double bond via a palladium-catalysed Heck reaction, a reliable and powerful method for the assembly of this class of alkene.

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References

  1. O’ Sullivan TP, Vallin KSA, Shah STA, Fakhry J, Maderna P, Scannell M, Sampaio ALF, Perretti M, Godson C, Guiry PJ (2007) J Med Chem 50:5894

    Article  Google Scholar 

  2. Heck RF, Nolley JP (1972) J Org Chem 37:2320

    Article  CAS  Google Scholar 

  3. Nicolaou KC, Bulger PG, Sarlah D (2005) Angew Chem Int Ed Engl 44:4442

    Article  CAS  Google Scholar 

  4. Katsuki T, Sharpless KB (1980) J Am Chem Soc 102:5974

    Article  CAS  Google Scholar 

  5. Jager V, Schroter D, Koppenhoefer B (1991) Tetrahedron 47:2195

    Article  Google Scholar 

  6. Romero A, Wong C (2000) J Org Chem 65:8264

    Article  CAS  Google Scholar 

  7. Grignard V (1900) Compt Rend Acad Sci Paris 130:1322

    CAS  Google Scholar 

  8. Wothers PGN, Warren S, Clayden J (2001) Inorganic chemistry, Oxford University Press, New York

    Google Scholar 

  9. Parker RE, Isaacs NS (1959) Chem Rev 59:737

    Article  CAS  Google Scholar 

  10. Jarowicki K, Kocienski P (1998) J Chem Soc, Perkin Trans 1(23):4005

    Google Scholar 

  11. Smitha G, Chandrasekhar S, Reddy SC (2008) Synth 6:829

    Google Scholar 

  12. Ishihara K, Nakayama M, Ohara S, Yamamoto H (2002) Sci 290:1140

    Article  Google Scholar 

  13. Ishihara K, Nakayama M, Ohara S, Yamamoto H (2002) Tetrahedron 58:8179

    Article  CAS  Google Scholar 

  14. Sharma GVM, Reddy KL, Sree Lakshmi P, Radha Krishna P (2004) Tetrahedron Lett 45:9229

    Article  CAS  Google Scholar 

  15. Singh S, Duffy CD, Shah STA, Guiry PJ (2008) J Org Chem 7:6429

    Article  Google Scholar 

  16. Singh S, Guiry PJ (2009) Eur J Org Chem 12:1896

    Google Scholar 

  17. Singh S, Guiry PJ (2009) J Org Chem 74:5758

    Article  CAS  Google Scholar 

  18. Corey EJ, Venkateswarlu A (1972) J Am Chem Soc 94:6190

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. UCD School of Chemistry and Chemical Biology, Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland

    Colm Duffy

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  1. Colm Duffy
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Correspondence to Colm Duffy .

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© 2012 Springer-Verlag Berlin Heidelberg

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Duffy, C. (2012). Synthesis of Heck Coupling Partner for the Preparation of Heteroaromatic Lipoxin A4 Analogues. In: Heteroaromatic Lipoxin A4 Analogues. Springer Theses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24632-6_3

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