Abstract
Nowadays nanotechnology has become a technological field with great potential since it can be applied in almost every aspect of modern life. One of the sectors where nanotechnology is expected to play a vital role is the field of medical science. The interaction of nanotechnology with medicine gave birth to a completely new scientific field called nanomedicine. Nanomedicine is a field that aims to use the nanotechnology tools and principles in order to improve human health in every possible way. Nanotechnology provides monitoring tools and technology platforms that can be used in terms of detection, diagnostic, bioanalysis and imaging. New nanoscale drug-delivery systems are constantly designed with different morphological and chemical characteristics and unique specificity against tumours, offering a less harmful approach alternative to chemo- and radiotherapies. Furthermore, nanotechnology has led to great breakthroughs in the field of tissue engineering, making the replacement of damaged tissues and organs a much feasible procedure. The thorough analysis of bio and non-bio interactions achieved by versatile nanotools is essential for the design and development of highly performed medical implants. The continuous revolution in nanotechnology will result in the fabrication of nanostructures with properties and functionalities that can benefit patient’s physiology faster and more effectively than conventional medical procedures and protocols. The number of nanoscale therapeutical products is rapidly growing since more and more nanomedical designs are reaching the global market. However the nanotoxic impact that these designs can have on human health is an era that requires still more investigation. The development of specific guidance documents at a European level for the safety evaluation of nanotechnology products in medicine is strongly recommended and the need for further research in nanotoxicology is identified. Ethical and moral concerns also need to be addressed in parallel with the new developments.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
K. Park, “Nanotechnology: What it can do for drug delivery”, perspective, J. Contr. Release 120, 1–3 (2007)
W.H. de Jong, B. Roszek, R.E. Geertsma, “Nanotechnology in medical applications: possible risks for human health”, RIVM report 265001002, 2005. RIVM, National Institute for Public Health and the Environment, Bilthoven, The Netherlands, 2005
B. Roszek, W.H. de Jong, R.E. Geertsma, “Nanotechnology for medical applications: state-of-the-art in materials and devices”, RIVM report 265001001, 2005. RIVM, National Institute for Public Health and the Environment, Bilthoven, The Netherlands, 2005
http://www.nec.com/global/corp/H0602.html, http://www.gatech.edu/news-room/release, www.nanotech-now.com/news.cgi?story_id=10065
M. Foldvari, M. Bagonluri, “Carbon nanotubes as functional excipients for nanomedicines: II. Drug delivery and biocompatibility issues”, Nanomed.: Nanotechnol. Biol. Med. 4(3), 183–200 (2008)
H.S. Mansur, “Quantum dots and nanocomposites”, Wiley Interdiscipl. Rev.: Nanomed. Nanobiotechnol. (2)2, 113–129 (2010)
L.D. True, X. Gao, “Quantum dots for molecular pathology: Their time has arrived”, J. Mol. Diagnostics 9(1), 7–11 (2007)
S. Svenson, “Dendrimers as versatile platform in drug delivery applications”, Eur. J. Pharm. Biopharm. 71(3), 445–462 (2009)
B. Haley, E. Frenkel, “Nanoparticles for drug delivery in cancer treatment”, Urol. Oncol.: Semin. Original Investig. 26(1), 57–64 (2008)
A. Shahverdi, A. Fakhimi, H. Shahverdi, S. Minaian, “Synthesis and effect of silver nanoparticles on the antibacterial activity of different antibiotics against Staphylococcus aureus and Escherichia coli”, Nanomed.: Nanotechnol. Biol. Med. 3(2) 168–171 (2007)
G.A. Silva, “Introduction to nanotechnology and its applications to medicine”, Surg. Neurol. 61, 216 (2004)
D. Khatayevich, M. Gungormus, H. Yazici, C. So, S. Cetinel, M. Hong, A. Jen, C. Tamerler, M. Sarikaya, “Biofunctionalization of materials for implants using engineered peptides”, Acta Biomater. 6(12), 4634–4641 (2010)
http://www.sciencemuseum.org.uk/antenna/nano/skin/123.asp (a), http://ltfn.physics.auth.gr/facilities/xrr.html (b), http://www.aist-nt.com/450/plasmid-in-buffer/ (c)
S. Logothetidis, M. Gioti, S. Lousinian, S. Fotiadou, “Haemocompatibility studies on carbon-based thin films by ellipsometry”, Thin Solid Films 482(1–2), 126 (2004)
H. Elwing, “Protein absorption and ellipsometry in biomaterial research”, Biomaterials 19, 397 (1998)
E. Garcia-Caurel, J. Nguyen, L. Schwartz, B. Drévillon, “Application of FTIR ellipsometry to detect and classify microorganisms”, Thin Solid Films 455, 722 (2004).
E. Garcia-Caurel, J. Nguyen, L. Schwartz, B. Drévillon, “Moving ellipsometry from materials to medicine”, III–Vs Rev. 17, 4 (2004)
H. Arwin, “Application of ellipsometry techniques to biological materials”, Thin Solid Films 519(9), 2589–2592, (2011)
Nanomedicine, An ESF – European Medical Research Councils (EMRC) Forward Look report 2005, (http://www.nanoforum.org)
K. Mitsakakis, S. Lousinian, S. Logothetidis, “Early stages of human plasma proteins adsorption probed by atomic force microscope”, Biomol. Eng. 24(1), 119–124, (2007)
http://www.plant.wageningen-ur.nl/news/2001-10_en.htm; http://www.spacedaily.com/news/nanotech-05zzzzg.html; http://www.biomaterial.co.jp/en/products/
C. Wei, “Highlights of the first annual meeting of the American Academy of Nanomedicine”, Nanomed.: Nanotechnol. Biol. Med. 1, 351 (2005)
J. Maienschein, “Regenerative medicine’s historical roots in regeneration, transplantation and translation”, Dev. Biol. (Article in Press), (2010).
J. Vacanti, “Tissue engineering and regenerative medicine: from first principles to state of the art”, J. Pediatr. Surg. 45, 291–294 (2010)
E. Anitua, M. Sanchez, G. Orive, “Potential of endogenous regenerative technology for in situ regenerative medicine”, Adv. Drug Deliv. Rev. 62(7–8), 741–752 (2010)
D.L. Borjesson, J.F. Peroni, “The regenerative medicine laboratory: facilitating stem cell therapy for equine disease”, Clin. Lab. Med. 31(1), 109–123, (2011)
D. Sheyn, O. Mizrahi, S. Benjamin, Z. Gazit, G. Pelled, D. Gazit, “Genetically modified cells in regenerative medicine and tissue engineering”, Adv. Drug Deliv. Rev. 62(7–8), 683–698, (2010)
I. Martin, D. Wendt, M. Heberer, “The role of bioreactors in tissue engineering”, Trends Biotechnol. 22(2), 80–86, (2004)
Y. Martin, P. Vermette, “Bioreactors for tissue mass culture: Design, characterization and recent advances”, Biomaterials 26, 7481–7503, (2005)
A.B. Yeatts, J.P. Fisher, “Bone tissue engineering bioreactors: Dynamic culture and the influence of shear stress”, Bone 48, 171–181, (2011)
C. Van Blitterswijk, P. Thompsen, J. Hubbell, R. Cancedda, A. Lindahl, J.D. De Bruijn, J. Sohier, D.F. Williams, Tissue Engineering, Chapter 16: Bioreactors for tissue engineering, 483–506, (Academic, New York, 2008).
A. Robert, J.D. Freitas, “What is nanomedicine?”, Nanomed.: Nanotechnol. Biol. Med. 1(2) (2005)
R.F. Service, “Nanotechnology takes aim at cancer”, Science 310(5751), 1132 (2005).
M.M. Stevens, J.H. George, “Exploring and engineering the cell surface interface”, Science 310(5751), 1135 (2005)
V.P. Zharov, J.W. Kim, et al.,, “Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy”, Nanomed.: Nanotechnol. Bio. Med. 1, 326 (2005)
G. Korpanty, et al., “Targeting of VEGF-mediated angiogenesis to rat myocardium using ultrasonic destruction of microbubbles”, Gene Ther. 12, 1305 (2005)
A.C. Morton, D. Crossman, J. Gunn, (2004) The influence of physical stent parameters upon restenosis, Pathologie Biologie 52, 196–205 (2004)
X. Chen, K. Fujise, “Restenosis: Emerging molecular targets. Going beyond drug-eluting stents”, Drug Discov. Today: Dis. Mech./Cardiovasc. Dis. 2(I) (2005)
http://www.pharmsci.neu.edu/researchcenters/center_cardiotargeting.html
C. Zandonella, “The tiny toolkit”, Nature 423, 10–12 (2003)
I. Brigger, C. Dubernet, P. Couvreur, “Nanoparticles in cancer therapy and diagnosis”, Adv. Drug Deliv. Rev. 54, 631–651 (2002)
T.K. Jain, S.P. Foy, B. Erokwu, S. Dimitrijevic, C.A. Flask, V. Labhasetwar, “Magnetic resonance imaging of multifunctional pluronic stabilized iron-oxide nanoparticles in tumor-bearing mice”, Biomaterials, 30(35), 6748–6756, (2009)
D.E. Sosnovik, M. Nahrendorf, R. Weissleder, “Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications”, Basic Res. Cardiol. 103(2), 122–130, (2008)
B. Bonnemain, “Superparamagnetic agents in magnetic resonance imaging: physiochemical characteristics and clinical applications – a review”, J. Drug Target 6, 167–174 (1998)
T. Neuberger, B. Schopf, H. Hofmann, M. Hofmann, B. Von Rechenberg, “Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system”, J. Magn. Magn. Mater. 293(1) 483–496 (2005)
E.S. Kawasaki, T.A. Player, “Nanotechnology, nanomedicine, and the development of new, effective therapies for cancer”, Nanomed.: Nanotechnol. Biol. Med. 1, 101–109 (2005)
C. Tachung, P.E. Yih, C. Wie, “Nanomedicine in cancer treatment”, Nanomed.: Nanotechnol. Biol. Med. 1, 191–92 (2005)
V. Zharov, V. Galitovsky, M. Viegas, “Photothermal detection of local thermal effects during selective nanophotothermolysis”, Appl. Phys. Lett. 83, 4897 (2003)
V.P. Zharov, V. Galitovsly, M. Viegas, “Photothermal guidance of selective photothermolysis with nanoparticles”, Proc. SPIE 5319, 291 (2004)
D.P. O’Neal, L.R. Hirsch, N.J. Halas, J.D. Payne, J.L. West, “Photothermal tumor ablation in mice using near infrared-absorbing nanoparticles”, Cancer Lett. 209, 171 (2004)
J. Bradbury, “Nanoshell destruction of inoperable tumors”, Lancet Oncol. 4, 711 (2003)
X. Huang, M.A. El-Sayed, “Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy”, J. Adv. Res. 1(1), 13–28, (2010)
Willems & van den Wildenberg, NanoRoadMap Project, October 2004, (http://www.nanoroadmap.it/sectoral%20reports/sect%20report%20health.PDF)
A. Hett et al., “Nanotechnology: Small matter, many unknowns”, Swiss Reinsurance Company (2004) (http://www.swissre.com/INTERNET/pwswpspr.nsf/fmBookMarkFrameSet?ReadForm&BM=./vwAllbyIDKeyLu/ulur-5yaffs?OpenDocument)
Y. Pan, A. Leifert, D. Ruau, S. Neuss, J. Bornemann, G. Schmid, W. Brandau, U. Simon, W. Jahnen-Deschent, “Gold nanoparticles of diameter 1,4 nm trigger necrosis by oxidative stress and mitochondrial damage”, Small 5(18), 2067–2076, (2009)
N. Singh, B. Manshian, G. Jenkins, S. Griffiths, P. Williams, T. Maffeis, C. Wright, S. Doak, “NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials”, Biomaterials 30, 3891–3914, (2009)
M.C. Roco, “Nanotechnology: convergence with modern biology and medicine”, Curr. Opin. Biotechnol. 14, 337 (2003)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Logothetidis, S. (2012). Nanomedicine: The Medicine of Tomorrow. In: Logothetidis, S. (eds) Nanomedicine and Nanobiotechnology. NanoScience and Technology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24181-9_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-24181-9_1
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-24180-2
Online ISBN: 978-3-642-24181-9
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)