Abstract
In the first part of the book, we discussed different aspects of the analysis of dose-response data such as estimation, inference, and modeling. In the second part of the book, we focus on dose-response microarray experiments. Within the microarray setting, a dose-response experiment has the same structure as described in Part I of the book. The response is the gene expression at a certain dose level. The role of functional genomics, particularly in this setting, is to find indications of both safety and efficacy before the drug is administrated to patients. In Chap. 5, we give an overview about dose-response microarray experiments and their data structure.
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Bijnens, L. et al. (2012). Functional Genomic Dose-Response Experiments. In: Lin, D., Shkedy, Z., Yekutieli, D., Amaratunga, D., Bijnens, L. (eds) Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R. Use R!. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24007-2_5
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DOI: https://doi.org/10.1007/978-3-642-24007-2_5
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