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Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane pp 31–67Cite as

Collective Response of Self-Organised Clusters of Mechanosensitive Channels

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Abstract

In this chapter we aim to determine how the spatial organization can affect the function of membrane channels, which are regulated by membrane elastic forces. We map the short-range elastic interactions into a discretized system of interacting spins, from which the spatial distribution of the channels is obtained, and its effect on the gating dynamics. We illustrate the analysis by considering the special type of channels activated directly by membrane tension called mechanosensitive channels, in E. coli.

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Notes

  1. 1.

    The diameter of a single lipid is approximately \(0.75 \,\hbox{nm}.\)

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Authors and Affiliations

  1. Department of Physics, Institute of Complex Systems and Mathematical Biology, University of Aberdeen, Meston Building, Aberdeen, AB24 5EE, UK

    Ksenia Guseva

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  1. Ksenia Guseva
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Guseva, K. (2012). Collective Response of Self-Organised Clusters of Mechanosensitive Channels. In: Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane. Springer Theses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23988-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-23988-5_3

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