Skip to main content

Purging False Negatives in Cancer Diagnosis Using Incremental Active Learning

  • Conference paper
Intelligent Data Engineering and Automated Learning - IDEAL 2011 (IDEAL 2011)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 6936))

  • 1786 Accesses

Abstract

Cancer is becoming a human plague, and decision-support tools to help physicians better diagnosing are a fulsome research field. False negatives can be a huge problem for cancer diagnosticians, since while a false positive can result in time and money lost, a false negative can result in the lost of human lives, which puts an overwhelming burden on diagnosis.

In this framework, we propose a two-fold approach to purge false negatives in cancer diagnosis without compromising precision performance. First, we use an incremental background knowledge method and then, an active learning strategy completes the procedure. The defined incremental active learning SVM method was tested in the Wisconsin-Madison breast cancer diagnosis problem showing the effectiveness of such techniques in supporting cancer diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Merz, C.J., Murphy, P.M.: UCI repository of machine learning data bases, Irvine, CA (1998), http://www.ics.uci.edu/mlearn/MLRepository.html

  2. Wrensch, M., Georgianna Farren, T.C., Flavia Belli, J.B., Clarke, C., Erdmann, C.A., Lee, M., Moghadassi, M., Peskin-Mentzer, R., Quesenberry, C.P., Souders-Mason, V., Spence, L., Suzuki, M., Gould, M.: Risk factors for breast cancer in a population with high incidence rates. Breast Cancer Res. 5, 88–102 (2003)

    Article  Google Scholar 

  3. Mangasarian, O., Street, W., Wolberg, W.: Breast cancer diagnosis and prognosis via linear programming. Operations Research 43(4), 570–577 (1995)

    Article  MathSciNet  MATH  Google Scholar 

  4. Fogel, D.B., Wasson, E.C., Boughon, E.M., Porto, V.W., Angeline, P.J.: Linear andneural models for classifying breast masses. IEEE Transactions on Medical Imaging 17(3), 485–488 (1998)

    Article  Google Scholar 

  5. Xing, K., Chen, D., Henson, D., Sheng, L.: A clustering-based approach to predict outcome in cancer patients. In: ICMLA, pp. 541–546 (2007)

    Google Scholar 

  6. Oprea, A., Strungaru, R., Ungureanu, G.: A Self Organizing Map approach to breast cancer detection. In: International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2008, pp. 3032–3035 (2008)

    Google Scholar 

  7. Hong, J., Cho, S.: Incremental Support Vector Machine for Unlabeled Data Classification. In: ICONIP, pp. 1403–1407 (2002)

    Google Scholar 

  8. Liu, B., Dai, Y., Li, X., Lee, W., Yu, P.: Building Text Classifiers Using Positive and Unlabeled Examples. In: ICDM, pp. 179–188 (2003)

    Google Scholar 

  9. Seeger, M.: Learning with Labeled and Unlabeled Data, Technical Report, Institute for Adaptive and Neural Computation. University of Edinburgh (2001)

    Google Scholar 

  10. Silva, C., Ribeiro, B., Lopes, N.: Improving Recall Values in Breast Cancer Diagnosis with Incremental Background Knowledge. In: WCCI 2010 (2010)

    Google Scholar 

  11. Silva, C., Ribeiro, B.: On Text-based Mining with Active Learning and Background Knowledge using SVM. Journal of Soft Computing - A Fusion of Foundations, Methodologies and Applications 11(6), 519–530 (2007)

    Google Scholar 

  12. Silva, C., Ribeiro, B.: Improving text classification performance with incremental background knowledge. In: Alippi, C., Polycarpou, M., Panayiotou, C., Ellinas, G. (eds.) ICANN 2009. LNCS, vol. 5768, pp. 923–931. Springer, Heidelberg (2009)

    Chapter  Google Scholar 

  13. Vapnik, V.: The Nature of Statistical Learning Theory, 2nd edn. Springer, Heidelberg (1999)

    MATH  Google Scholar 

  14. Zelikovitz, S., Hirsh, H.: Using LSI for text classification in the presence of background text. In: Tenth International Conference on Information Knowledge Management, pp. 113–118 (2001)

    Google Scholar 

  15. Joachims, T.: Transductive Inference for Text Classification using Support Vector Machines. In: International Conference on Machine Learning, pp. 200–209 (1999)

    Google Scholar 

  16. Silva, C., Ribeiro, B.: Labeled and Unlabeled Data in Text Categorization. In: IEEE International Joint Conference on Neural Networks (2004)

    Google Scholar 

  17. Alex, G., Monaco, J., Doyle, S., Basavanhally, A., Reddy, A., Seiler, M., Ganesan, S., Bhanot, G., Madabhushi, A.: Towards improved cancer diagnosis and prognosis using analysis of gene expression data and computer aided imaging. Experimental Biology and Medicine 234(8), 860–879 (2009)

    Article  Google Scholar 

  18. Ribeiro, B.: Learning Adaptive Kernels for Model Diagnosis. Frontiers in Artificial Intelligence and Applications, vol. 104, pp. 563–571. IOS Press, Amsterdam (2003)

    Google Scholar 

  19. Akay, M.: SVM combined with feature selection for breast cancer diagnosis. Expert Systems with Applications, Part 2 36(2), 3240–3247 (2009)

    Article  Google Scholar 

  20. Cruz, J., Wishart, D.: Applications of machine learning in cancer prediction and prognosis. Cancer Informatics 2, 59–77 (2006)

    Google Scholar 

  21. Schohn, G., Cohn, D.: Less is more: Active Learning with Support Vector Machines. In: International Conference on Machine Learning, pp. 839–846 (2000)

    Google Scholar 

  22. Schölkopf, B., Burges, C., Smola, A.: Advances in Kernel Methods - Introduction to Support vector Learning, pp. 1–15. MIT Press, Cambridge (1999)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Silva, C., Ribeiro, B. (2011). Purging False Negatives in Cancer Diagnosis Using Incremental Active Learning. In: Yin, H., Wang, W., Rayward-Smith, V. (eds) Intelligent Data Engineering and Automated Learning - IDEAL 2011. IDEAL 2011. Lecture Notes in Computer Science, vol 6936. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23878-9_47

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-23878-9_47

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-23877-2

  • Online ISBN: 978-3-642-23878-9

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics